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4 months ago
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6 months ago
Check out our exciting paper by
@asmafarhat.bsky.social
in
@scienceimmuno.bsky.social
. In a nutshell: in lung fibrosis, the age of the bone marrow matters more than the age of lung tissue. check out the threat by Asma below π Thanks to co-lead
@miershawig.bsky.social
and all collaborators :)
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reposted by
Asma Farhat
6 months ago
1/ Excited to share my first-ever first-author paper out now in Science Immunology! from
@knapplab.bsky.social
and co-supervised by
@miershawig.bsky.social
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis. π
www.science.org/doi/10.1126/...
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An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence
Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.
https://www.science.org/doi/10.1126/sciimmunol.adk5041
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