Pedro Santamaria (@p-santamaria.bsky.social)

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs Mir, M., Bickmore, W., Furlong, E. E. M. & Narlikar, G. Chromatin topology, condensates and gene regulation: shifting paradigms or just a phase? Development https://doi.org/10.1242/dev.182766 (2019). Sabari, B. R., Dall’Agnese, A. & Young, R. A. Biomolecular condensates in the nucleus. Trends Biochem. Sci. 45, 961–977 (2020). Li, W. & Jiang, H. Nuclear protein condensates and their properties in regulation of gene expression. J. Mol. Biol. 434, 167151 (2022). Schuettengruber, B., Bourbon, H. M., Di Croce, L. & Cavalli, G. Genome regulation by polycomb and trithorax: 70 years and counting. Cell 171, 34–57 (2017). Loubiere, V., Martinez, A. M. & Cavalli, G. Cell fate and developmental regulation dynamics by Polycomb proteins and 3D genome architecture. Bioessays 41, e1800222 (2019). Blackledge, N. P. & Klose, R. J. The molecular principles of gene regulation by Polycomb repressive complexes. Nat. Rev. Mol. Cell Biol. 22, 815–833 (2021). Piunti, A. & Shilatifard, A. The roles of Polycomb repressive complexes in mammalian development and cancer. Nat. Rev. Mol. Cell Biol. 22, 326–345 (2021). Lau, M. S. et al. Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science 355, 1081–1084 (2017). Plys, A. J. et al. Phase separation of Polycomb-repressive complex 1 is governed by... https://www.nature.com/articles/s41588-026-02586-y