@brumbaugh-lab.bsky.social
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reposted by
Florencia Levin Ferreyra
5 days ago
There are many ways to make your voice heard and participate in all that the
#ISSCR2026
Annual Meeting has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more!
invt.io/1lxby1coomp
@isscr.org
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Fun project with
@distefanolab.bsky.social
looking at RNA regulation in cell fate decisions. Check out the great summary below and see the full work in
@natbiotech.nature.com
:
www.nature.com/articles/s41...
add a skeleton here at some point
11 days ago
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reposted by
Nature Biotechnology
11 days ago
Selective RNA sequestration in biomolecular condensates directs cell fate transitions -
@distefanolab.bsky.social
@brumbaugh-lab.bsky.social
go.nature.com/3X215du
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Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
https://go.nature.com/3X215du
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Check out this new preprint with
@distefanolab.bsky.social
lab! The manuscript focuses on RNA processing in the form of sequestration into P-bodies in the context of development.
add a skeleton here at some point
6 months ago
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Thanks to
@isscr.org
for this wonderful recognition! And thanks to my colleagues and ISSCR for thoughtfully and carefully working on important policy and regulatory matters. Read more about the award and my fellow honorees.
invt.io/1bxbk540w9k
@isscr.org
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I am a 2025 ISSCR Public Service Award Honoree.
Learn more
https://invt.io/1bxbk540w9k
8 months ago
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Thanks to
@cp-cellchembiol.bsky.social
,
@iamzico.bsky.social
and Ramesh Shivdasani for this thoughtful discussion of our work!
add a skeleton here at some point
8 months ago
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reposted by
8 months ago
Our work on the regulation is out
www.cell.com/stem-cell-re...
! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine.
#pluripotency
#epigenetics
#stemcells
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Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells
Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities, posing a hurdle to their safe use in biomedical applications. Using pluripotent cells with defined genetic bac...
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(25)00054-2
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reposted by
Nature Cell Biology
9 months ago
💫NEW:
@brumbaugh-lab.bsky.social
, Dempsey & co show that
#H3K36
methylation maintains
#intestinal
epithelial fate commitment, whereas its suppression induces a plastic state and expression of genes involved in
#regeneration
. 👉🏿https://rdcu.be/eayN3
www.nature.com/articles/s41...
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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium - Nature Cell Biology
Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state and expression of genes ...
https://www.nature.com/articles/s41556-024-01580-y
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reposted by
Stylianos Lefkopoulos (he/him)
9 months ago
🥂Congrats to
@brumbaugh-lab.bsky.social
& co for their new study in
@naturecellbiology.bsky.social
showing that H3K36 methylation maintains
#intestinal
epithelial fate commitment and is involved in
#regeneration
.
rdcu.be/d8awu
www.nature.com/articles/s41...
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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium
Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...
https://rdcu.be/d8awu
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reposted by
Bruno Di Stefano
9 months ago
1/ Pleased to share our review, published today
@natrevimmunol.bsky.social
, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development.
www.nature.com/articles/s41...
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Biomolecular condensates in immune cell fate - Nature Reviews Immunology
Recent studies suggest that biomolecular condensates — membrane-less assemblies of proteins and nucleic acids — are involved in regulating gene expression to ensure proper immune cell development. Thi...
https://www.nature.com/articles/s41577-025-01130-z#Sec18
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Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online:
rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at
@naturecellbiology.bsky.social
for the opportunity!
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H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium
Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...
https://rdcu.be/d5AEc
10 months ago
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