Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience

Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer. bit.ly/3WUiuo1

A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

Congratulations Rotem Sorek @soreklab.bsky.social on receiving the Gruber prize today in Stockholm

Happy birthday Molly! Wishing you an awesome day and looking forward to a year of experiments that (mostly) go as planned, unexpected discoveries, and plenty of lab laughter. You make our micro world brighter every day! 🎉🧬

Outcome of Lego Lab happy hour 🧑‍🔬 @mskcancercenter.bsky.social @mskeducation.bsky.social #LabLife #newPI

Come be my boss! My dept. at GT is searching for a new chair. Drop me a line if you are interested, I'd be happy to talk about this position, GT, ATL- anything. It's a drama-free department filled with cool people in a dynamic city. www.biosciences.gatech.edu/chair-search

Lego Lab happy hour! @mollymonge.bsky.social @annaadels.bsky.social @vickyzhuhongyu.bsky.social #newPI

1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77

Another amazing discovery from the @audeber.bsky.social lab, working with @enzopoirier.bsky.social to demonstrate functional conservation of immune mechanisms across domains of life! Congrats to @hugovaysset.bsky.social and co-authors!!

Next up from our lab - a ring nuclease with a novel fold which cleaves all cOA species involved in Type III CRISPR defence. It's also found in plasmid and phage genomes, where it presumably functions as an anti-CRISPR. www.biorxiv.org/content/10.1...

A new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity. www.biorxiv.org/content/10.1...

Amazing opportunity

Preprint: “Structural modeling reveals viral proteins that manipulate host immune signaling” Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules Congrats Nitzan Tal! www.biorxiv.org/content/10.1...

When you open a lab across the street from your postdoc lab 🙈 Thank you @annaadels.bsky.social for documenting your NYC adventures so beautifully! #newPI #MicroSky #LabLife

Things are cooking! First transformations in the Aviram Lab! @mskeducation.bsky.social @mskcancercenter.bsky.social #newPI

Join the #VosshallLab as a postdoctoral scientist. Fully funded, right here in New York City @rockefelleruniv.bsky.social hhmi.wd1.myworkdayjobs.com/en-US/Extern...

our lab is blessed to have 3 new postdoctoral fellow positions. we would welcome scientists interested in...

What an inspiration @marlenebelfort.bsky.social!! Beautiful and personal interview with @rnasociety.bsky.social: www.rnasociety.org/dr--marlene-...

CRISPR-Cas regulation by a non-canonical sigma factor that seems to be linked to quorum sensing 🤯 Super cool work! www.biorxiv.org/content/10.1...

BEAUTIFUL work and great thread! Congratulations @leahhouri.bsky.social @leslievosshall.bsky.social 🎉

It was a truly incredible meeting, thank you @audeber.bsky.social and team for hosting! Next year in NYC! 🤩

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

Had an absolute blast at the @mskcancercenter.bsky.social PDA Night Science event w/ @itaiyanai.bsky.social —improv exercises, big ideas, & a glimpse into the brilliant future of science! A pleasure to be hosted for such an inspiring and fun evening. #NightScience #FutureOfScience

Our collaborative project with Matthias Stadtfeld and Jason Mezey labs has now been published. We examined how genetic variation impacts regulation of DNA methylation at the control regions of imprinted genes in naive pluripotent stem cells. www.cell.com/stem-cell-re...

mtDNA manipulations using enzymes derived from bacteria and phages. Beautiful work by @agnelsfeir.bsky.social @danapeer.bsky.social and teams!

Susan Gottesman and Gisela Storz, pioneers in regulatory RNA research, reflect on their personal scientific journeys and the evolution of their groundbreaking group research in two compelling articles. Gigi: www.sciencedirect.com/science/arti... Susan: www.sciencedirect.com/science/arti... #RNA

Shout out to Sloan Kettering @mskcancercenter.bsky.social for supporting basic science / foundational biology... www.mskcc.org/news/cryo-el...

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

Kavli NSI @rockefelleruniv.bsky.social member & former Director Leslie Vosshall has been awarded the 2025 Scolnick Prize in Neuroscience for her groundbreaking work on the neural mechanisms of mosquito behavior. 🦟🔬 Congrats, Dr. Vosshall! 🎉 #Neuroscience #KavliNeuro mcgovern.mit.edu/2025/03/03/l...

Mosquito cell atlas! Congratulations on an incredibly ambitious and well executed project @oliviagoldman.net @nadavshai.bsky.social @leslievosshall.bsky.social et al !!!

I can’t wait to stand up for science on Friday! Join us in the DC rally or another rally in virtually any other state!

1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social. www.nature.com/articles/s41...

If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...

MSK has been recognized as one of the national's top workplaces for inclusion and diversity by @newsweek.com magazine. 🎉 MSK earned five stars, the highest ranking, among mid to large employers in America. Learn more: www.newsweek.com/rankings/ame...

The Eligo team did it again! We just shared on biorxiv the work we did towards the development of a CRISPR-Cas therapy targeting Shiga Toxin producing E. coli (STEC). www.biorxiv.org/content/10.1...

My lab’s first preprint! We used functional metagenomics to identify phage defenses in human and soil microbiomes. We scaled these selections while maintaining accuracy, enabling us to examine 9 habitats for defense elements against 7 phages. www.biorxiv.org/content/10.1... 1/10

Here we go! #newPI #WomenInSTEM @mskeducation.bsky.social @mskcancercenter.bsky.social

we recently found some really neat RNA-guided DNA-cutting systems in phages. Despite remarkable similarities to CRISPR systems, including encoding guide RNAs in arrays, they appear entirely evolutionarily distinct (but definitely related to snoRNAs 🤓) We decided to call them TIGR-Tas systems 🐯

Last day as a postdoc 🥹 Cleared my bench, hugged some exceptional people goodbye. Ready to be a #newPI first thing Monday!

If you are worried about science there IS something that you can do! Join us next Friday in DC to make your voice heard. Come and stand up for science! Show that science is for everyone. I’ll be there and I can’t wait to see you there too! @standupforscience.bsky.social

All those asking about a Stand Up For Science event in NYC, here you go! www.eventbrite.com/e/stand-up-f...

Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!

Beautiful and important work! Congratulations to @davidlabmsk.bsky.social and all who were involved!

New version of DefenseFinder available defensefinder.mdmlab.fr (& cli) Now encompassing 263 systems (+111 this year..!). Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models

I escaped poverty because I am a scientist. And I am a scientist because of the National Science Foundation. A 🧵:

Please check out our preprint where we find that mitotic transcription helps ensure ecDNA inheritance through chromosomal tethering: www.biorxiv.org/content/10.1...

New mechanism of gene transfer! With @tcostalab.bsky.social @imperialcollegeldn.bsky.social, we discovered that cf-PICIs form tail-less elements that, once released, spread among different bacterial species by hijacking tails from various phages. More exciting news soon! shorturl.at/kRJqE

Happy to share our latest piece of work on the PARIS bacterial immune system. We performed a detailed characterization of the AriB Toprim nuclease, the effector of PARIS immunity. www.biorxiv.org/content/10.1...