Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...

How do you move from static DNA models to real-time mechanics? Join our next webinar to see how the team of Dr. Xiaolan Zhao at MSKCC uses the LUMICKS C-Trap to decode the molecular determinants of Smc5/6 association with DNA junctions. 🔗 web.lumicks.com/l/970813/202...

Explore SMC mechanism and regulation at EMBO Workshop "Threads of life: SMC complexes in #chromosome structure and dynamics" in #Bengaluru, IN, 13–18 Dec 2026. Registration/Abstract submission by 1 Apr/1 May https://meetings.embo.org/event/26-smc-complexes#chromosome#Bengaluru#EMBOThreadsOfLife #genesky #EMBOevents 🧪

Happy to share our perspective on the DNA translocation mechanism by the CMG helicase. DNA translocation by the CMG helicase: the helical inchworm model url: portlandpress.com/biochemsoctr...

Nice to see some yeast genetics in a Cell paper, where the authors test models based on single-molecule in vitro analysis. The combination of genetics and biochemistry often addresses questions most effectively. www.cell.com/cell/fulltex...

Join SGD at #Yeast26 for cutting-edge #yeast research, networking opportunities, engaging talks, poster sessions, and workshops, for everyone from early career scientists to experienced researchers! Abstract submission by Mar5, early registration ends Apr16. See you there! @genetics-gsa.bsky.social

Hi all! We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids. www.biorxiv.org/content/10.6... #3DGenome #chromatin #Cohesin #centromere

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! www.science.org/doi/10.1126/...

Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...

Beautiful, layered argument for the use of model organisms, especially small ones, in research. A must read!

Cryo-EM captures the elusive moment when E1 hands off SUMO to E2- a molecular relay that’s been mostly guesswork until now. The structures reveal E1 doing dramatic shape-shifting to line up perfectly for the transfer, like enzyme origami in action.

Our paper is now out in Molecular Cell! Check the thread in this former post: www.cell.com/molecular-ce...

Interested in chromatin architecture?
 Checkout our new method - PCP - that can map genome organization as multi-way interactions as well as nucleosome footprint and nucleosome spacing at very high resolution. www.biorxiv.org/content/10.1...

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

Happy to share a new work from the lab on how DNA damage checkpoint can be down-regulated. rdcu.be/d5o3E. Congrats to all authors at @mskcancercenter.bsky.social and our Weill BCMB student @tzippora.bsky.social. gradschool.weill.cornell.edu/bcmb-allied-...

Our latest paper showing that DNA nicks drive expansions of both normal and disease-size alleles. All credit goes to a fantastic graduate student Liangzi Li as well as to a terrific team of current and former undergraduate and graduate students in the lab. www.pnas.org/doi/10.1073/pnas.2413298121

If you are interested in pursuing a PhD in biomedical sciences in New York City, it is still time to apply to the BCMB program run jointly by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center ! Deadline: Dec 1, 2024.

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn