James Watson has died www.nytimes.com/2025/11/07/s...

Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software. www.nature.com/naturecareer... Apply by 25 NOV #PostdocJobs #ScienceJobs

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

Ready for a transformative research journey? 🚀 Join the vibrant, interdisciplinary PhD programmes at NTU College of Science in Singapore! We offer fully funded scholarships. Hear from our students and faculty in the video below 👇 youtu.be/JeZHiXu3fgE

We are hiring! Interested? Apply here: go.mbl.edu/AS1887

Have a look at this Tools of the Trade Article I wrote for @natrevmcb.nature.com on decoding #ubiquitin signals inside cells using UbiREAD! Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:

We're counting down to the 2025 WARF Innovation Awards! Meet our second nominee, a computer scientist with a system that helps computers use GPUs more efficiently, making AI and other apps work better. #WisconsinInnovates

Single-molecule friends! The prelim. program of next year's sm- #Gordon conference in Switzerland is online: www.grc.org/single-molec... It'll be 3x fantastic: science, people, place in the alps ⛰️. Kevin & I hope to see you all next June: Have a look, tell your friends, and register!

🧬🧪Research Technician Position Open🧬🧪 HHMI, UT Austin. Biochemistry/Biophysics- Assist recombinant protein expression, purification and structural analysis (protein NMR and CryoEM) to uncover the mechanisms of cell fate specification in plants. hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Socioeconomic roots of academic faculty Tenure-track faculty are up to 25 times more likely to have a parent with a Ph.D. Moreover, this rate nearly doubles at prestigious universities and is stable across the past 50 years. #AcademicSky

please look here for more information about a postdoc position careers.mskcc.org/vacancies/93...

Excited to share my first PhD student’s @biorxivpreprint.bsky.social! Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules! Check it out! www.biorxiv.org/content/10.1...

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

Halloween pumpkin carving experiment by the Lim lab. 🎃

Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social www.science.org/doi/10.1126/...

Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

Sequence and ionic requirements of pUG fold quadruplexes https://www.biorxiv.org/content/10.1101/2025.10.28.685102v1

My department, Cornell BME, is hiring! This tenure-track faculty position is a great opportunity to join a vibrant community that values research, teaching, and entrepreneurship. 📝 academicjobsonline.org/ajo/jobs/30816

Very cool collaborative work between multiple groups across three institutions. Shoutout to @rhodamine110.bsky.social and his crew along with longtime @the.3i.social community @so-lets-kilab70.bsky.social for deploying 3i's #latticelightsheet for some particularly elegant chromatin microscopy. 🔥🔬🧠🧬🥽

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n facultypositions.stanford.edu/en-us/job/49...

warmest congratulations to Scott Emr and Wes Sundquist for being awarded the 2025 World Laureate Association Prize in life science or medicine english.shanghai.gov.cn/en-Latest-Ta... WLA doesnt do a great job advertizing in the US so i am doing their job for them. So well deserved!

@science.org 🧬🔬🐛🔭🌊🌳🧫🐳

🦠🐝🧬🐳This short blog shares many interesting facts about our magazine that I didn’t know before @science.org 📰🖼️⚛️⚗️🔭🧪🔬The evolving face of Science | Science | AAAS www.science.org/content/blog...

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...

Visualizing influenza A virus assembly by in situ cryo-electron tomography www.nature.com/articles/s41...

Hi Everyone for the @asbmb.bsky.social 2026 annual meeting there is now a deferred payment option for federal employees and scientists impacted by the government shutdown. Information below and further details at the link. www.asbmb.org/annual-meeti...

Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky

Our lab @mrclmb.bsky.social in Cambridge is seeking a passionate PhD student to explore transcription-coupled splicing! Join our team for an exciting project to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry www2.mrc-lmb.cam.ac.uk/students/int...

Join us on Monday Oct. 27 for Biochemistry Colloquium with James Berger. The Berger Lab focuses on molecular mechanisms & cellular functions of multisubunit assemblies that control the organization, preservation & flow of genetic information. More info: today.wisc.edu/events/view/...

We train machine learning models on millions of proteins. But when it comes to making predictions, do we need them to understand all proteins at once? Often, we need an accurate model for the specific protein we are studying or designing. We address this with ProteinTTT arxiv.org/abs/2411.02109 1/🧵

Excited to share a new chapter of my scientific journey in Chris Russo's group — developing a way to freeze proteins faster than they diffuse, paving the way for cryo-EM without air–water interface damage.

Two tenure-track faculty positions open in our department: 1) Microbial Ecology and Evolution careers.rpi.edu/en-us/job/49... 2) Cellular Neuroscience careers.rpi.edu/en-us/job/49... Join our collaborative, interdisciplinary community, which has proved to be a fantastic place to start a lab!

UGA is seeking a tenure-track Assistant Professor to develop an innovative research program focused on disease mechanisms. The ideal candidate will use cryo-EM and other structural techniques, with potential applications to future therapies. Apply here: www.ugajobsearch.com/postings/456...

Van Andel Institute PhD program application is OPEN! Van Andel Institute has 39 faculty members that work in: epigenetics, cancer biology, neurodegenerative diseases, structural biology, metabolism, nutritional programming and cell biology. www.vai.org/graduate-sch...

Looking to start your PhD in 2026? Check out the opportunities available at the LMB here: www2.mrc-lmb.cam.ac.uk/students/int... Applications now open! Deadline: 2nd DEC

Thrilled to share our multidisiplinary work on how genome-wide DNA bridging by H-NS reshapes the stationary phase bacterial nucleoid and affects the transcriptional landscape. With Xindan Wang and @meyerroc.bsky.social www.biorxiv.org/content/10.1...

Congratulations to Mimi and her team!

Registration is open for the 2025 SoCal Genome Stability Symposium. Free registration. All talks by trainees. www.cityofhope.org/genome-stabi...

New #Traklab publication in @narjournal.bsky.social "Residues in the little finger domain of the Y-family Dpo4 DNA polymerase communicate to restrict synthesis past 8-oxoguanine lesions" academic.oup.com/nar/article/...

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Wait, disordered proteins can be enzymes, too? It's a confusing world for sure.

8/10 Furthermore, when equipped with the template sequence from the telomerase RNA, DRT10 readily synthesized telomeric DNA repeats.

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...