45 novel protein folds in the updated AFESM (AFDB + ESMatlas) manuscript: • 12 high-confidence folds in AFESM • 33 by ColabFold-repredicting 2.3M low-quality domains We show AFDB captures most domains already and ESMfold struggles with novelty 🌏 afesm.foldseek.com 📄 biorxiv.org/content/10.1...

🎉 Congrats to 2026 Thomas Hunt Morgan Medal recipient Judith Kimble of @uwbiochem.bsky.social! Her work has built an entire field and inspired generations of scientists through her mentorship and leadership. 🔗Read more: buff.ly/0yzHXvk

Congratulations to the legendary scientist Judith Kimble!!! We stand on the shoulders of giants. #womeninSTEM #celegans

Machines on Genes 2026 8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Two deadlines coming up on 8 April 2026 i. abstract submission ii. early bird submission (save €50) Four days of 🧑‍🔬🧬👩‍🔬☀️👨‍🔬🔬❄️🧪🧫 94th Harden Conference by @lapassmore.bsky.social, Dana Branzei, me with @biochemsoc.bsky.social.

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

Association of orphan nuclear receptors and heterochromatin are involved in Alternative Lengthening of Telomeres – Liuh-Yow Chen and coworkers identify their link as the transcriptional corepressor TRIM28 Thanks to @reviewcommons.org for another #RefereedPreprint link.springer.com/article/10.1...

The University of Waterloo is seeking internationally renowned scholars, especially those working in #CryoEM, for the prestigious Canada Impact+ Research Chairs program- Chairs receive long-term funding & institutional support - Learn More zurl.co/JBfJ9

Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

Supercoiling not only brings DNA to life (and makes it dance) but also changes how key proteins such as #CRISPR interact with it. Thanks @qmsmith.bsky.social for the brilliant collaboration, Sylvia for developing an amazing new #imageanalysis pipeline & @eddierollins.bsky.social for beautiful #AFM.

The next #CryoEM Current Practices Webinar speaker will be by Rashmi Panigrahi from Memorial University of Newfoundland, St. John’s, Canada speaking on "Capturing Chromatin Dynamics During the DNA Damage Response" 3/26/2026 at 12 PM ET / 9AM PT. Register today: us02web.zoom.us/webinar/regi...

Adenosine 5'-triphosphate (ATP) forms protein-free and responsive condensates in crowded environments https://www.biorxiv.org/content/10.64898/2026.03.22.713448v1

Apply now! The 2026 call for the EMBO Young Investigator Programme is now open with a deadline of 1 April 12:00 midday CEST. 🧪 More info here: https://www.embo.org/funding/fellowships-grants-and-career-support/young-investigator-programme/ #LifeSciences #research #funding

“T-loop Dynamics: Telomere Structure Shapes Cell Fate Decisions” is out now in @cp-trendscellbio.bsky.social . www.cell.com/trends/cell-... It was a pleasure to work on this with collaborator and friend @makotothayashi.bsky.social, whose insight was central to shaping the ideas in this review.

Last call to join Dr. Xiaolan Zhao (MSKCC) to witness the frontier of DNA biology. You can’t miss this chance to see how the LUMICKS C-Trap is enabling her team at MSKCC to decode the "how" behind the Smc5/6 complex. Secure your spot before we go live: web.lumicks.com/l/970813/202...

Happy to announce that my institution, @irbbarcelona.org, is opening two group leader positions, 1 in chemical biology and 1 in structural biology, to strengthen our expertise in molecular sciences: please spread the word !

1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).

Happy 30th birthday to this paper published March 22, 1996, one of the studies that moved chromatin biology from correlation toward mechanism. Brownell et al. linked a transcription-associated Tetrahymena HAT to yeast Gcn5p, providing a biochemical link for chromatin modification to gene activation.

We're #hiring a financial manager! The financial manager works closely with departmental leadership to provide strategic oversight of our research administration and financial operations. Learn more and apply by April 17: jobs.wisc.edu/jobs/financi...

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains

Why do we remember some moments—and forget others? 🧠 This #BrainAwarenessWeek, explore 5 facts about #memory, from how it forms to how diseases like #Alzheimers disrupt it. 🔗 Read more: bit.ly/3PnnNcH @danafoundation.bsky.social#BrainAwarenessWeek

How do pairs of DNA loci - such as enhancers and promoters - find each other inside the nucleus? 🤔 Most models assume the random forces driving locus motion are independent in space New preprint by @janniharju.bsky.social: this assumption fails in living cells 🧵 www.biorxiv.org/content/10.6...

We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…)

Single-molecule peptide sequencing through reverse translation of peptides into DNA | Nature Biotechnology https://www.nature.com/articles/s41587-026-03061-z

Cryo-EM success starts before the microscope. Join us @royalmicrosoc.bsky.social for a free Cryo-EM SPA mini-course (1 of 3) on sample prep. Learn purification, grid prep & screening tips + live Q&A. 🗓️ Apr 14 Register once to attend all 3 - Sample Prep, Collection, Processing 👉 ter.li/pksdqb

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

Transposable elements, such as retrotransposons and endogenous retroviruses, are increasingly recognized for their important roles in genome function and impact on disease development go.nature.com/4tQ1zTn rdcu.be/e8Eci

You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list. www.ebi.ac.uk/about/news/t...

Great to see this work now out: doi.org/10.1002/anie... Here are some of the fantastic HS-AFM movies of DNA origami strand displacement dynamics 🎬 It was a pleasure collaborating and contributing to this work led by Chalmers Chau, Paolo Actis and Christoph Wälti.

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...

Epigenetics Update - Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains bit.ly/3NmLO5Q Edwina McGlinn and Chen Davidovich (Monash University) reporting in Mol Cell #Epigenetics #PRC2 #H3K27me3 --- Perfect for cancer, immunology, and aging; epigenometech.com

Transposable elements, such as retrotransposons and endogenous retroviruses, are being recognized for their important roles in genome function and impact on disease development. How can we translate our growing understanding of the 'dark genome' into therapeutics? go.nature.com/4tQ1zTn rdcu.be/e7D2N

Meet Reinier Hernandez, assistant professor of @wiscmedphys.bsky.social @uwiscradiology.bsky.social, whose Advanced Radiotheranostics Laboratory aims to harness the power of radionuclides to tackle problems in diverse areas of biomedical research.

Development of a photostable pH biosensor based on mStayGold https://www.biorxiv.org/content/10.64898/2026.03.06.710027v1

ICYMI: New online: A proteome-wide dependency map of protein interaction motifs

Our lab is hiring a research technician! We are interested in reproduction, stem cells, and development. If you are seeking a robust 2-year career experience before the next chapter of your educational journey, this is the position for you! hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you! 1/n

I was on Capitol Hill today with @asbmb.bsky.social urging lawmakers to support strong federal investment in scientific research and training. Also to support : predictable and sustained funding. #ASBMBAdvocates #ScienceServesUsAll

I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...

The results are finally in! 🏆💻🧬 I'm thrilled to announce that the manuscript for the Bits to Binders protein design competition is out on bioRxiv! Here's a summary of our findings, including some simple criteria that nearly *double* success rates when applied as a filter 🧵

"Brian looks for enzymes that have evolved to harness them for new, industrial uses, like the deconstruction of biomass for use in biorenewable chemicals and fuels," says Jennifer Gottwald, WARF director of licensing.

Dorothy Crowfoot Hodgkin, biochemist & a trailblazer in crystallography, she established the biomolecular structures of insulin, vitamin B12, & penicillin winning the Nobel in Chemistry in 1964 #WomensHistoryMonth #WomenInStem #WomenInScience

Paper alert from @codyz.bsky.social y.social and Yang Liu. New mechanism for chromatin remodeling by ATRX. Super cool story. Congrats to #lugerlab alumni. www.biorxiv.org/content/10.6...

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 ! www2.rnasociety.org

👀 At #BPS but haven’t stopped by booth 401 yet? Meet the team to discover how you can unlock the ultimate #single-molecule resolution at your benchtop, generating high-impact insights into #biomolecular interactions and dynamics. See you there! @biophysicalsoc.bsky.social #biophysics #lifescience

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...

Just published in @science.org with related Perspective by Françoise Jacob-Dubuisson. Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization | Science www.science.org/doi/10.1126/...