Phil Kyriakakis
@breakliquid.bsky.social
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📥 3143
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Senior Research Scientist at Stanford Bioengineering | Taking apart and building biology.🧪
I tried to "squeeze gel purify" DNA, sent it for sequencing, and it worked! ~Protocol: 1) cut out band 2) poke hold in small tube, put gel in it, put in big tube 3) Spin for 2-3 seconds 4) sequence the liquid in the bottom tube This may not always work, but cool!
@plasmidsaurus.bsky.social
6 days ago
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iGEM is not your typical scientific conference!
@igemcommunity.bsky.social
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14 days ago
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“Bang-Bang optimal light control for maximum protein production in yeast” - love this title
hal.science/hal-05323963...
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https://hal.science/hal-05323963/document
16 days ago
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So many beautiful pictures and I love papers that benchmark a bunch of tools.
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19 days ago
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If you want your research to sound “basic”, call it “basic research”. - I don’t think the general public will think it is very important. I like “fundamental science” better. Today I saw “frontier science”, which sounds cooler and more important.
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https://better.today
22 days ago
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www.cell.com/cell/abstrac...
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Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains
A family of rationally designed time-resolved fluorescent proteins with controllable lifetimes across the visible spectrum enables simultaneous multiplexed live imaging, super-resolution microscopy, a...
https://www.cell.com/cell/abstract/S0092-8674(25)01027-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286742501027X%3Fshowall%3Dtrue
24 days ago
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Phil Kyriakakis
Oded Rechavi
27 days ago
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
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Phil Kyriakakis
Nature Portfolio
28 days ago
A paper in Nature Communication reports on a new method to produce strong, biodegradable plastic from bamboo. The bioplastic resembles oil-based plastics in strength, shapeability, and thermal stability but can biodegrade in soil within 50 days.
go.nature.com/4h1xv0X
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Phil Kyriakakis
Grant Jacobs BioinfoTools/NotJustDNA 🔬🧬🖥️✍️📚
about 1 month ago
🧪 I’d have never guessed it either ⬇️
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@zebrafishrock.bsky.social
does anyone here study age-related vision loss in fish? Or vision generally?
about 1 month ago
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Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope
www.nature.com/articles/s41...
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Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope - Nature Communications
Loretan and colleagues present a low-cost smartphone-based microscope capable of detecting single-molecule fluorescence. This approach opens doors to personalised and widely distributed applications in diagnostics, biosensing, and science education.
https://www.nature.com/articles/s41467-025-63993-z
about 1 month ago
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Smile 😃
add a skeleton here at some point
about 1 month ago
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Phil Kyriakakis
Lenint.bsky.social
about 1 month ago
🧪"In doing so, Arnold has mastered the art of a good apology: one that doesn’t veer into excusing oneself; that gives context where relevant; but accepts full responsibility and moves on".
www.theguardian.com/science/2020...
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Nobel prize winner demonstrates the best way to apologize
Unfortunately there aren’t Nobel prizes for good apologies – but Dr Frances Arnold’s words should be an example to all of us
https://www.theguardian.com/science/2020/jan/06/nobel-prize-winner-demonstrates-best-way-apologize-chemist-frances-arnold?CMP=share_btn_url
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WAChRs are excitatory opsins sensitive to indoor lighting
www.biorxiv.org/content/10.1...
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WAChRs are excitatory opsins sensitive to indoor lighting
Hundreds of novel opsins have been characterized since the advent of optogenetics, but low experimental throughput has limited the scale of opsin engineering campaigns. We modified an automated patch-...
https://www.biorxiv.org/content/10.1101/2025.09.12.675947v1
about 1 month ago
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Phil Kyriakakis
Chise
about 1 month ago
Their efficacy was confirmed against LIVE viruses including Ebola, Marburg, Nipah, Hendra, SARS-CoV, SARS-CoV-2 (COVID-19), AND Middle East Respiratory Syndrome (MERS). The study has been published in Science Advances. YES, it is PEER-REVIEWED. •
www.science.org/doi/10.1126/...
🧪🧵⬇️
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Phil Kyriakakis
Oded Rechavi
about 1 month ago
Got to love studies that were clearly conducted "for the love of the game" (“self-decapitating sea slugs”, “plants that see and use that for mimicry”, “worms that jump in the air”, aka papers you sometimes find in
@currentbiology.bsky.social
) References to all of this bellow👇
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I hope my algorithm can regenerate too
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about 2 months ago
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I really want to use "behooves me" in this writing (grant), but Grammarly doesn't want me to!
about 2 months ago
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Lalo says happy whatever day it is
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about 2 months ago
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Mr Kitten says happy Saturday
about 2 months ago
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What else should I record with IR?
add a skeleton here at some point
about 2 months ago
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Your gel running in the IR!
about 2 months ago
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Phil Kyriakakis
Scientist Network for Advancing Policy
5 months ago
It's not too late to participate in
#McClintockLetters
! Check out all the resources we have available and get writing:
tinyurl.com/McClintockLettersInitiative
Please don't hesistate to reach out with any questions!
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What a figure
www.nature.com/articles/s41...
2 months ago
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Love seeing this mCherry in sf9 cells!
2 months ago
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How cool is it to get messages like that?! Wow! So much of the joy of science is the mentorship I get to give, its the mentees!
2 months ago
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More reason not to use the old site:
www.yahoo.com/news/article...
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Thousands of private user conversations with Elon Musk’s Grok AI chatbot have exposed on Google Search
More than 370,000 Grok chats have been indexed by search engines, exposing sensitive queries that include intimate medical and psychological questions, business details, and at least one password.
https://www.yahoo.com/news/articles/thousands-private-user-conversations-elon-173216941.html
3 months ago
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Finally! Someone recognized my expertise in “topics”
3 months ago
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What does this part of a cytometer do? (The clear cube part)
3 months ago
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Phil Kyriakakis
Harmit Singh Malik
3 months ago
To have this paper appear the same day that RFK Jr is canceling all mRNA vaccine funding is further indication that irony is not dead, even though we might all be soon.
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Eric Topol
3 months ago
RFK Jr and HHS just ended all US supported mRNA vaccine development
www.hhs.gov/press-room/h...
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https://www.hhs.gov/press-room/hhs-winds-down-mrna-development-under-barda.html
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kickstarter idea: tongue gene therapy for people that don’t like cilantro 🌿
3 months ago
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Phil Kyriakakis
Nature
3 months ago
This surprisingly relaxing footage is from SIX MILES under the ocean – and it’s the deepest ecosystem yet discovered
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How strange, no “mechanically separated meat”, EDTA or Whale oil?
4 months ago
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AI "Final_final_..."
4 months ago
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Happy Wednesday
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4 months ago
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Phil Kyriakakis
TheSnarkyFarmer
4 months ago
#Theoutpost
As the meteors blaze through Earth’s atmosphere at over 130,000 mph, they burn up in brilliant flashes of different colors – and those colors reveal what elements are inside. More in alt
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Phil Kyriakakis
bioRxivpreprint
4 months ago
One Section, Two Worlds: Single-Cell Integration of MALDI-MSI and Spatial Transcriptomics on the Same Single Tissue Section
https://www.biorxiv.org/content/10.1101/2025.07.16.665110v1
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Phil Kyriakakis
BF Francis Ouellette
4 months ago
From
@alicemalivert.bsky.social
@marcusghosh.bsky.social & colleagues in
@plos.org
#Computational
#Biology
| Ten simple rules for navigating AI in science |
#Education
#Bioinformatics
#PLOSCBTSR
#OpenScience
#AI
🧬 🖥️ 🧪 🔓 ⬇️
journals.plos.org/ploscompbiol...
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Ten simple rules for navigating AI in science
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1013259
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I think many people would do this just for the hair.
www.nature.com/articles/s41...
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Psilocybin treatment extends cellular lifespan and improves survival of aged mice - npj Aging
npj Aging - Psilocybin treatment extends cellular lifespan and improves survival of aged mice
https://www.nature.com/articles/s41514-025-00244-x
4 months ago
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This could be fun
www.science.org/doi/10.1126/...
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Scalable emulation of protein equilibrium ensembles with generative deep learning
Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that...
https://www.science.org/doi/10.1126/science.adv9817
4 months ago
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Phil Kyriakakis
The Tennessee Holler
4 months ago
Disabled veteran. Citizen. Taken by Trump’s Gestapo. 🇺🇸
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Made with love
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4 months ago
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How cool is this?!
www.kickstarter.com/projects/blo...
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SparkBlocks: STEM blocks that click onto LEGO bricks
SparkBlocks bring your ideas to life: hands-on STEM circuits with motors, lights, and more that click onto the blocks you love!
https://www.kickstarter.com/projects/blockandcode/sparkblocks-stem-blocks-that-click-onto-lego-bricks?fbclid=IwQ0xDSwLYxd9leHRuA2FlbQEwAGFkaWQBqyFjHzxiaAEe9E_79Js0dz5wQIvvmyShbui83g0A0d3KaiJpQer4YRtejoXqlhw-DCmlYJ4_aem_2uxim2kVHR3lkmUeTsLUVA&utm_medium=paid&utm_source=fb&utm_id=120226513584080072&utm_content=120226522296660072&utm_term=120226522296600072&utm_campaign=120226513584080072
4 months ago
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Phil Kyriakakis
4 months ago
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Michael Buice
4 months ago
The ICE budget is now set to be approximately what the NIH budget was. We’re shifting money from solving real problems to solving fictitious problems.
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If they were planning to keep this all secret, maybe they shouldn’t have published it 🤷 So easy to 3D print a cylinder. Not sure how it is nonobvious…
pmc.ncbi.nlm.nih.gov/articles/PMC...
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Enhancing biolistic plant transformation and genome editing with a flow guiding barrel
The biolistic delivery system is an essential tool in plant genetic engineering, capable of delivering DNAs, RNAs, and proteins independent of tissue type, genotype, or species. However, its efficienc...
https://pmc.ncbi.nlm.nih.gov/articles/PMC12216195/
4 months ago
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Phil Kyriakakis
Carl T. Bergstrom
4 months ago
We are finally hearing firsthand what happened at CECOT. At least 277 people illegally rendered from the US remain there, and President Trump is now talking about sending American citizens there. Do not let this slip from view.
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Phil Kyriakakis
Sebastian S. Cocioba
4 months ago
Another plasmid I am excited about offering is this fully open source Taq polymerase expression circuit. Inducible via lactose or IPTG. Ampicillin selected. Born free. You can make your own polymerase and purification is as easy as boiling water and centrifuging. Coming soon!
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