🎉 ¡Orgullo RSEQ! Nuestros socios @casadevallcarla.bsky.social, @nikinikki87.bsky.social y @carlosmyruela.bsky.social han sido galardonados con una prestigiosa #ERCStartingGrant 2025🔬 Enhorabuena!!!!! 📖 rseq.org/tres-miembro... @urv.cat @lcbm-epfl.bsky.social @iciq.org @icfo.eu

I am really excited that #CHEMTUBIO will be funded through an @erc.europa.eu Starting Grant! This funding will kickstart my lab next year and help us unveil the mechanisms and therapeutic implications of erasers of microtubule modifications. Stay tuned!

Six #BISTcommunity early-career researchers have secured prestigious ERC grants 👏 These awards highlight the ability of BIST Community centres to attract and nurture outstanding young international talent. @crg.eu @icfo.eu @iciq.org @ibecbarcelona.eu 👉http://bit.ly/486ENOq

Pint of Science was again a great success in Lausanne, with >500 people attending our events! Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳! #PINT25 #scicomm

If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬 Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support! doi.org/10.1126/scia...

Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇 www.science.org/doi/10.1126/...

The program for Pint of Science Lausanne 🧪 is ready! pintofscience.ch/events/lausa... This year we have again three venues covering topics from aging to robotic surgery or sustainable agriculture Come join us on the 19th, 20th and 21st of May 🥳 #PintCH #scicomm @pintofscience.ch

Very happy to see this story out in #JACS_Au! Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11 pubs.acs.org/doi/10.1021/... #ChemBio #chemsky #HDAC

!THREE OPPORTUNITIES TO JOIN US! We are looking for 3 (!!!) PhD students interested in: How Metabolism affects Genome Regulation. Join us at @carrerasijc.bsky.social as Marie Sklodowska Curie network fellow. More info: 2 x experimental: www.nuclear-dn.eu 1 x computational: www.hubmol.eu

🚨 Excited to share our work @elife.bsky.social doi.org/10.7554/eLife.98827.2 on targeting Hepatitis B virus #HBV 🦠 capsid aggregation by designed molecules! #DrugDiscovery #ChemBio Thanks V Khayenko C Makbul @clemensschulte.bsky.social & @boettchercryoem.bsky.social for stunning #CryoEM visuals!

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 www.nature.com/articles/s41... (1/8) #ChemBio #ChemSky

Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules. #CryoEm https://elifesciences.org/articles/105335?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights

Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉) "Bluesky is much better for science. There is much less toxicity, misinformation, and distractions." www.nature.com/articles/d41...

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X https://go.nature.com/42tH8Ai

A nice commentary article by @carlosmyruela.bsky.social y.social and @beatfierz.bsky.social has been already published! Thank you, Carlos and Beat! elifesciences.org/articles/105...

Here is our most recent reviewed preprint on MagIC-cryo-EM invented by @yarimura.bsky.social elifesciences.org/reviewed-pre... Please note that this is not the final version, or VOR. A revised version (www.biorxiv.org/content/10.1...) is currently being reviewed at eLife.

Happy to share the latest preprint from my PhD studies on the discovery of de novo macrocyclic inhibitors of HDAC11. This was a great collaboration between @christianaolsen.bsky.social lab (@carlosmyruela.bsky.social, @tnhansen.bsky.social) and Christian Heinis lab (@alexanderln.bsky.social).

New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social 🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶 chemrxiv.org/engage/chemr...

Happy to share a fun collaboration between EPFL and UCPH initiated by @carlosmyruela.bsky.social, Christian Heinis, @christianaolsen.bsky.social and I! Big shout-out to @danieladankova.bsky.social who spearheaded the project. Now out on @chemrxiv.bsky.social chemrxiv.org/engage/chemr...

We’re no experts but this sounds like it might be suboptimal for disseminating research.

We are working on the program for the 5th Virtual ChemBioTalks on September 30th, 2025. While we already have commitments by our keynotes @oconnorlab.bsky.social and @craigmcrews.bsky.social, the remaining program is still in planning. Whom would you most like to hear at our next event?

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

Btw check out our collaborative effort with the Walter Lab to map nucleosome acidic patch interactors for all nuclear proteins: predictomes.org/view/acidicp...

If you're seeing "Invalid Handle" on your profile, this should resolve on its own — thanks for your patience!! 🦋

Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻 We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie... ⏰ Application deadline = November 15

The mammalian Zn-dependent #HDACs are very diverse. They target various acyl-lysine modifications and acetylation of polyamines and other molecules. This study led by Michael Lammers and Leonie Graf (Uni Greifswald) trace these features in bacteria🦠! t.co/LGfZ5Esmo5 1/6

Inhibitors of histone deacetylases (#HDACs) have longer and longer on-target residence times, which may help future clinical applications. How is this achieved? Check out our new #OpenAccess Perspective in JACS_Au, with Yasir Raouf, to know more! 👇🏻 pubs.acs.org/doi/10.1021/...

Another piece of the histone lactylation puzzle falls into place: Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis nature.com/articles/s41589-024-01680-8# #lactate #chembio

Imbuing peptide libraries with drug-likeness: rdcu.be/dxxCi Nice News&Views article by Sunit Pal and Peter ‘t Hart!

The Frei Research Group will open its doors this summer @ethzurich.bsky.social! I am therefore looking for motivated PhD students to join me in developing chemistry inspired tools for advanced fluorescence microscopy. Please share with current master students 👩‍🔬🔬⚗️🧪👨‍🔬http://tinyurl.com/437xyu8n

Histone deacylases (#HDACs and #sirtuins) have specific and quite different ways of finding their targets through #chromatin 🧬. Why do we know this, and what are we doing to study it in detail? All the info in our new review with @beatfierz.bsky.social! 👇🏻 portlandpress.com/biochemsoctr...

The work of Xingyuu Liu and Jerome Waser, in collaboration with us and the Radenovic lab and funded within project SeleCHEM (ERC), on the gold catalyzed macrocyclization of peptide-EBXs to make fluorescent macrocycles is now in JACS! pubs.acs.org/doi/10.1021/...

Second day of the #EFMCISCB2023 conference starting now in Basel. It's been a fantastic combination of MedChem and ChemBio talks so far! If you are around, come find me today at poster 56 to hear about #sirtuin sensors.

#EFMCISCB2023 is off to a great start with an insightful lecture by John Tallarico from the Novartis Institutes of Biomedical Research talking about the importance of chemical biology in the pharmaceutical industry. Exciting applications to proximity-inducing small molecules.