Hayden Nunley
@haysconun.bsky.social
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Oklahomo. Associate Research Scientist at
#FlatironCCB
. The opinions expressed are my own.
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Hayden Nunley
Current Biology
7 days ago
HAPPY HOLIDAYS TO ALL OF YOU!🎄✨
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The Center for Computational Biology at the Flatiron Institute is accepting applications for summer intern positions. CCB is a great place to work, and the intern program is excellent. Please check out the Computer Vision and Developmental Dynamics groups in particular.
apply.interfolio.com/177779
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/177779
15 days ago
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Dan 🐟 C
23 days ago
Exciting new
#Zebrafish
research from the
#WeinsteinLab
, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” —
www.biorxiv.org/content/10.6...
Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)
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Yaniv Elkouby
30 days ago
Now out from our lab in
@currentbiology.bsky.social
! An mTOR-Stat3-Stathmin pathway controls
#centrosome
and
#microtubule
dynamics for
#oocyte
polarization
www.cell.com/current-biol...
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It was a joy to co-organize this meeting. The work presented and discussed at the meeting was exceptional. The experimental methods for quantifying key aspects of germ cell development are getting better — and the time is ripe for proposing and testing mathematical modeling of these processes!
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about 1 month ago
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Hayden Nunley
Bardin Lab
about 1 month ago
Congrats Ben, Claude, et al! A beautiful characterization of roles of Ca++ waves and gap junction functions in tissue patterning!
www.science.org/doi/10.1126/...
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Retinal calcium waves coordinate uniform tissue patterning of the Drosophila eye
Optimal neural processing relies on precise tissue patterning across diverse cell types. Here, we show that spontaneous calcium waves arise among non-neuronal support cells in the developing Drosophil...
https://www.science.org/doi/10.1126/science.ady5541
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Hayden Nunley
Current Biology
about 1 month ago
Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University.
www.cell.com/current-biol...
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Q & A
Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard Univ...
https://www.cell.com/current-biology/fulltext/S0960-9822(25)01339-9
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Yaniv Elkouby
about 1 month ago
Was a pleasure to participate in ScoRe - Scientific Conference On REproduction - celebrating 150/y since the observation of sperm and egg pronuclear fusion in
@flatironinstitute.org
. A stellar gathering discussing all things germ cells! Thanks
@haysconun.bsky.social
, Stas Shvartsman for the invite!
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Nature Reviews Molecular Cell Biology
about 1 month ago
New Online! Signal control during tissue regeneration in adult animals
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Signal control during tissue regeneration in adult animals
Nature Reviews Molecular Cell Biology, Published online: 11 November 2025; doi:10.1038/s41580-025-00917-1The ability to track single cells in vivo, combined with insights into chromatin structure, immune–tissue crosstalk, bioelectric and metabolic cues and quantitative modelling, is changing our understanding of how tissues are repaired and renewed. This Review discusses how signals are regulated during regeneration and future directions for a more quantitative understanding of regenerative biology.
https://bit.ly/4ozWBqJ
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The Francis Crick Institute
3 months ago
This image shows neurons being grown on a surface with tiny patterns that resemble human tissue to ‘steer’ their growth. Models like this allow us to learn more about our nervous system and conditions like motor neurone disease. Image credit: Cathleen Hagemann and
@andreaserio.bsky.social
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Oded Rechavi
3 months ago
Got to love studies that were clearly conducted "for the love of the game" (“self-decapitating sea slugs”, “plants that see and use that for mimicry”, “worms that jump in the air”, aka papers you sometimes find in
@currentbiology.bsky.social
) References to all of this bellow👇
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Daniel Alber
3 months ago
A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in
@pnas.org
at
doi.org/10.1073/pnas...
with
@zhaoshh.bsky.social
, Alex Jacinto, Eric Wieschaus, Stas Shvartsman,
@lepuslapis.bsky.social
(1/8)
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Paul Francois
4 months ago
Super impressive study by the group of Stefano di Talia on the segmentation of zebrafish notochord. There might even be a SNIC !
www.biorxiv.org/content/10.1...
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Tissue-wide, synchronous Erk oscillations time the segmentation of the zebrafish notochord
The generation of a periodic body plan is a fundamental property of vertebrates. While biological oscillators provide a mechanism for timing the formation of repeated structures, few examples of signa...
https://www.biorxiv.org/content/10.1101/2025.08.28.672946v1.abstract
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Lendert Gelens
4 months ago
🧵Does the nucleus set the cell cycle clock? 🕒 In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked. 👉
doi.org/10.1016/j.cu...
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James Briscoe
4 months ago
Latest on Waddington Landscapes: Computational methods to fit dynamical landscapes directly to single cell data Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated Connects interpretable landscape models with data
www.biorxiv.org/content/10.1...
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Reconstructing Waddington's Landscape from Data
The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within d...
https://www.biorxiv.org/content/10.1101/2025.08.11.669575v1
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epithelial mechanics fan club
5 months ago
Synthetic materials accumulate damage with every mechanical challenge. Epithelial tissues are regularly loaded, yet healthy epithelia rarely rupture. Why? We are
@epmech.bsky.social
and
@baldaufsci.bsky.social
and in this thread we introduce you to cyclic loading.
bsky.app/profile/epim...
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Shivani Dharmadhikari
5 months ago
Rotation 1 introduced me to the amazing Physarum 😍💛 Amy, Zach, Ameya,
@haysconun.bsky.social
and Vita from
@gladfelterlab.bsky.social
were encouraging TA's.
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Eszter Posfai
5 months ago
Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing
@rpkimyip.bsky.social
, David Denberg and Denis Faerberg!
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Belated post, but I really enjoyed working as a theory buddy with the Gladfelter lab at MBL physiology. Was refreshing to work on an array of beautiful problems in fungi and slime molds. These big, syncytial cells challenge preconceptions about cell cycles, distribution of resources, and more.
5 months ago
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Miro Astore
5 months ago
That's a wrap! The results of the first
#cryoEM
heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.110
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Yogesh Goyal
5 months ago
Just noticed a super nice preview of our paper by
@ditalialab.bsky.social
and Alexandra Hiestand. As always, good editorial experience with
@cp-cellsystems.bsky.social
www.cell.com/cell-systems...
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Mahsa Mofidi
6 months ago
Watch: 6 Science Short Films Created by Flatiron Institute Researchers and Filmmakers
www.simonsfoundation.org/2025/06/18/w...
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Watch: 6 Science Short Films Created by Flatiron Institute Researchers and Filmmakers
The two-week-long Symbiosis program yielded six experimental short films about basic science.
https://www.simonsfoundation.org/2025/06/18/watch-6-science-short-films-created-by-flatiron-institute-researchers-and-filmmakers/
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James Briscoe
7 months ago
New work on dynamics of morphogen signaling: Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input Morphogen signalling dynamics + GRN for tissue patterning
www.biorxiv.org/content/10.1...
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Rapid transcriptional response to a dynamic morphogen by time integration
During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we inv...
https://www.biorxiv.org/content/10.1101/2025.06.09.658715v1
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Excited to share this newly published work:
link.aps.org/doi/10.1103/...
This is the product of a collaboration with Jianping Fu’s lab. We proposed a mathematical model for fate patterning by mechanical stresses. This model made a non-intuitive prediction that was confirmed by follow-up experiments.
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Generation of fate patterns via intercellular forces
A model for the generation of a cell fate pattern via a coupling between mechanical stress and cell fate is presented. $I\phantom{\rule{0}{0ex}}n$ $v\phantom{\rule{0}{0ex}}i\phantom{\rule{0}{0ex}}t\ph...
https://link.aps.org/doi/10.1103/PhysRevResearch.7.L022051
7 months ago
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Lars Brudvig
7 months ago
What is this? Believe it or not, a plant in bloom! Conopholis americana goes by several common names (bear corn is my fave). As a parasitic plant, it lacks chlorophyll and does no photosynthesis. Rather, it connects to oak roots and thieves the resources it needs
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Hayden Nunley
Simons Foundation
8 months ago
In a new special series called “Science, Promise and Peril in the Age of AI,”
@quantamagazine.bsky.social
looks far beyond AI-based research tools to explore how
#AI
is changing what it means to do
#science
and what it means to be a scientist.
www.quantamagazine.org/series/scien...
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AI Changes Science and Math Forever | Quanta Magazine
An exploration of how artificial intelligence is changing what it means to do science and math, and what it means to be a scientist.
https://www.quantamagazine.org/series/science-in-the-age-of-ai/
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Hayden Nunley
Simons Foundation
9 months ago
Our short film about our co-founder Jim Simons was nominated for the @Telly Awards. Help amplify the story of his incredible life and contributions to math and basic science by voting for our film here:
peoples.tellyawards.com/PublicVoting...
#science
#philanthropy
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Devanshi Jain
9 months ago
For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁 Done with some awesome colleagues
@florpratto.bsky.social
www.nature.com/articles/s41...
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Intercellular bridges are essential for transposon repression and meiosis in the male germline - Nature Communications
A conserved feature of metazoan meiosis is that it occurs in a syncytium. Here, the authors show that intercellular bridges that connect germ cells in a syncytium are critical for ensuring proper meio...
https://www.nature.com/articles/s41467-025-56742-9
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Hayden Nunley
Simons Foundation
9 months ago
ICYMI:
#FlatironCCB
scientist
@henryhmattingly.bsky.social
developed the first analytical model for predicting how bacteria spread in obstacle-laden environments. Read more:
www.simonsfoundation.org/2025/03/21/n...
#science
#biology
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New Model Predicts How Bacteria Navigate Obstacles to Spread
A Flatiron Institute scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles.
https://www.simonsfoundation.org/2025/03/21/new-model-predicts-how-bacteria-navigate-obstacles-to-spread/
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Pierre Haas
10 months ago
New
#preprint
: "A model for boundary-driven tissue morphogenesis"
arxiv.org/abs/2503.03688
. A great collaboration with
@danielalber.bsky.social
@zhaoshh.bsky.social
, Alexandre Jacinto, Eric Wieschaus, Stas Shvartsman.
@flatironinstitute.org
@mpipks.bsky.social
@mpi-cbg.de
@csbdresden.bsky.social
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Eszter Posfai
10 months ago
A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron). We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
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Hayden Nunley
Campàs Lab
10 months ago
How do the different posterior tissues affect the physical elongation of the body axis? Very happy to share the work led by Georgina Stooke-Vaughan, together with Shuo-Ting Yen and Sangwoo Kim, that we recently published in
@naturecomms.bsky.social
🥳 ▶️
www.nature.com/articles/s41...
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Edouard Hannezo
11 months ago
Excited to see this out - how single cell heterogeneities and cell-cell interactions synergize to drive tissue patterning during regeneration! See thread below!
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Jan Funke
11 months ago
How can we use machine learning to find subtle patterns in our data and have them visualized? Read the thread below to find out how! Or head to
@adjavon.bsky.social
's blog post and let Simon the duck walk you through it (like a duck of course):
tinyurl.com/yy7csdcd
www.biorxiv.org/content/10.1...
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Thibaut Brunet
12 months ago
Some beautiful palintomy for the weekend (in a non-animal, and even a non-holozoan!)
#SporangiumSaturday
#ProtistsOnSky
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Joel Marthelot
about 1 year ago
Fresh off the press, our work on wing deployment in Drosophila 🪰:
www.nature.com/articles/s41...
Work by: Simon Hadjaje, Ignacio Andrade-Silva, Marie-Julie Dalbe and Raphaël Clément
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Stefano Di Talia
about 1 year ago
Please spread the word! We are looking for postdoc(s) interested in quantitative problems in Development and Regeneration. Previous experience in quantitative biology is not required. We will support you and provide a great training environment if you are committed to learn new things.
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Tim Stearns
about 1 year ago
Ginkgo leaves are blanketing NYC in yellow. Little known
#cilia
fact: the sperm of Ginkgo trees are large cells with ~1000 cilia arranged in a spiral that have to swim a short distance to fertilize the egg. 1/2
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