HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

The Center for Computational Biology at the Flatiron Institute is accepting applications for summer intern positions. CCB is a great place to work, and the intern program is excellent. Please check out the Computer Vision and Developmental Dynamics groups in particular. apply.interfolio.com/177779

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

Now out from our lab in @currentbiology.bsky.social! An mTOR-Stat3-Stathmin pathway controls #centrosome and #microtubule dynamics for #oocyte polarization www.cell.com/current-biol...

It was a joy to co-organize this meeting. The work presented and discussed at the meeting was exceptional. The experimental methods for quantifying key aspects of germ cell development are getting better — and the time is ripe for proposing and testing mathematical modeling of these processes!

Congrats Ben, Claude, et al! A beautiful characterization of roles of Ca++ waves and gap junction functions in tissue patterning! www.science.org/doi/10.1126/...

Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...

Was a pleasure to participate in ScoRe - Scientific Conference On REproduction - celebrating 150/y since the observation of sperm and egg pronuclear fusion in @flatironinstitute.org. A stellar gathering discussing all things germ cells! Thanks @haysconun.bsky.social, Stas Shvartsman for the invite!

New Online! Signal control during tissue regeneration in adult animals

This image shows neurons being grown on a surface with tiny patterns that resemble human tissue to ‘steer’ their growth. Models like this allow us to learn more about our nervous system and conditions like motor neurone disease. Image credit: Cathleen Hagemann and @andreaserio.bsky.social

Got to love studies that were clearly conducted "for the love of the game" (“self-decapitating sea slugs”, “plants that see and use that for mimicry”, “worms that jump in the air”, aka papers you sometimes find in @currentbiology.bsky.social ) References to all of this bellow👇

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

Super impressive study by the group of Stefano di Talia on the segmentation of zebrafish notochord. There might even be a SNIC ! www.biorxiv.org/content/10.1...

🧵Does the nucleus set the cell cycle clock? 🕒 In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked. 👉 doi.org/10.1016/j.cu...

Latest on Waddington Landscapes: Computational methods to fit dynamical landscapes directly to single cell data Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated Connects interpretable landscape models with data www.biorxiv.org/content/10.1...

Synthetic materials accumulate damage with every mechanical challenge. Epithelial tissues are regularly loaded, yet healthy epithelia rarely rupture. Why? We are @epmech.bsky.social and @baldaufsci.bsky.social and in this thread we introduce you to cyclic loading. bsky.app/profile/epim...

Rotation 1 introduced me to the amazing Physarum 😍💛 Amy, Zach, Ameya, @haysconun.bsky.social and Vita from @gladfelterlab.bsky.social were encouraging TA's.

Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

Belated post, but I really enjoyed working as a theory buddy with the Gladfelter lab at MBL physiology. Was refreshing to work on an array of beautiful problems in fungi and slime molds. These big, syncytial cells challenge preconceptions about cell cycles, distribution of resources, and more.

That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv! biorxiv.org/content/10.110

Just noticed a super nice preview of our paper by @ditalialab.bsky.social and Alexandra Hiestand. As always, good editorial experience with @cp-cellsystems.bsky.social www.cell.com/cell-systems...

Watch: 6 Science Short Films Created by Flatiron Institute Researchers and Filmmakers www.simonsfoundation.org/2025/06/18/w...

New work on dynamics of morphogen signaling: Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input Morphogen signalling dynamics + GRN for tissue patterning www.biorxiv.org/content/10.1...

Excited to share this newly published work: link.aps.org/doi/10.1103/... This is the product of a collaboration with Jianping Fu’s lab. We proposed a mathematical model for fate patterning by mechanical stresses. This model made a non-intuitive prediction that was confirmed by follow-up experiments.

What is this? Believe it or not, a plant in bloom! Conopholis americana goes by several common names (bear corn is my fave). As a parasitic plant, it lacks chlorophyll and does no photosynthesis. Rather, it connects to oak roots and thieves the resources it needs

In a new special series called “Science, Promise and Peril in the Age of AI,” @quantamagazine.bsky.social looks far beyond AI-based research tools to explore how #AI is changing what it means to do #science and what it means to be a scientist. www.quantamagazine.org/series/scien...

Our short film about our co-founder Jim Simons was nominated for the @Telly Awards. Help amplify the story of his incredible life and contributions to math and basic science by voting for our film here: peoples.tellyawards.com/PublicVoting... #science #philanthropy

For my first science post here, I’m proud to advertise our latest work exploring why germ cell connectivity is really important for meiosis 🐁 Done with some awesome colleagues @florpratto.bsky.social www.nature.com/articles/s41...

ICYMI: #FlatironCCB scientist @henryhmattingly.bsky.social developed the first analytical model for predicting how bacteria spread in obstacle-laden environments. Read more: www.simonsfoundation.org/2025/03/21/n... #science #biology

New #preprint: "A model for boundary-driven tissue morphogenesis" arxiv.org/abs/2503.03688. A great collaboration with @danielalber.bsky.social @zhaoshh.bsky.social, Alexandre Jacinto, Eric Wieschaus, Stas Shvartsman. @flatironinstitute.org @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron). We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.

How do the different posterior tissues affect the physical elongation of the body axis? Very happy to share the work led by Georgina Stooke-Vaughan, together with Shuo-Ting Yen and Sangwoo Kim, that we recently published in @naturecomms.bsky.social 🥳 ▶️ www.nature.com/articles/s41...

Excited to see this out - how single cell heterogeneities and cell-cell interactions synergize to drive tissue patterning during regeneration! See thread below!

How can we use machine learning to find subtle patterns in our data and have them visualized? Read the thread below to find out how! Or head to @adjavon.bsky.social's blog post and let Simon the duck walk you through it (like a duck of course): tinyurl.com/yy7csdcd www.biorxiv.org/content/10.1...

Some beautiful palintomy for the weekend (in a non-animal, and even a non-holozoan!) #SporangiumSaturday #ProtistsOnSky

Fresh off the press, our work on wing deployment in Drosophila 🪰: www.nature.com/articles/s41... Work by: Simon Hadjaje, Ignacio Andrade-Silva, Marie-Julie Dalbe and Raphaël Clément

Please spread the word! We are looking for postdoc(s) interested in quantitative problems in Development and Regeneration. Previous experience in quantitative biology is not required. We will support you and provide a great training environment if you are committed to learn new things.

Ginkgo leaves are blanketing NYC in yellow. Little known #cilia fact: the sperm of Ginkgo trees are large cells with ~1000 cilia arranged in a spiral that have to swim a short distance to fertilize the egg. 1/2