Fantastic work coming out of Neil Hunter’s lab! www.nature.com/articles/s41...

Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu @univie.ac.at @meduniwien.ac.at

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3] 📺 youtu.be/JmlY5omxQVc 📄 www.nature.com/articles/s41...

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....

A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...

Check this out if you ever wondered what intercellular bridges might be doing during meiosis! Happy to have played a small role! Congrats!!! @thejainlab.bsky.social

This is an important shift - the long awaited new Ensembl web site is ready for beta testing - is smooth, scrollable genome loveliness +clean views of the complex information - but @ensembl.bsky.social needs your help to get all the use cases out. Come to the webinar, and check out beta.ensembl.org

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin

Happy new year to all! I am delighted to say that our new preprint went on @biorxiv-genetic.bsky.social today! The work was a labor of love for Mercedes Carro from my lab and Alexis Dzuibek from Andrew Grimson's lab - congrats to all! #meiosis #meiosis4eva #RNA biorxiv.org/cgi/content/...

Home sweet home... New Year in the summer! #puntadeleste #uruguay

New preprint! How does meiosis work in non-model organisms? Together with Susana Coelho at the MPI for Biology Tübingen @mpi-bio-fml.bsky.social , we took a look at the proteins of the meiotic axis in the brown alga Ectocarpus www.biorxiv.org/content/10.1...

Uff Botafogo! 1 player down, 2 goals up! #CopaLibertadores

2024 Mid-Atlantic Meiosis Mini-Symposium!! 🐭🪱🪰🧬🦠Co-organized with @scienceleah.bsky.social and @florpratto.bsky.social at NIH. Amazing talks from trainees and new PIs🎉 #meiosis4eva

Crossover recombination between homologous chromosomes in meiosis: recent progress and remaining mysteries. #CrossoverRecombination #Chromosomes #Meiosis #TrendsInGenetics www.cell.com/trends/genet...

The Chromosome Biology Department of @raphmercier.bsky.social here at the Max Planck Institute for Plant Breeding Research Cologne (@maxplanck.bsky.social) is looking for a new group leader! jobs.mpipz.mpg.de/jobposting/8... #PlantScience #PlantSciJobs #GroupLeader #NewPI #PlantChromosomalBiology

Fantastic resource for bio icons: NIH Bioart Source Build figures, presentations, and illustrations with 2,000+ science and medical art visuals. This collection of high-quality, scientifically accurate vectors, #icons, and brushes is freely available within the public domain. bioart.niaid.nih.gov

It's #InternationalNachoDay! This graphic on kitchen chemistry hacks in @cenmag.bsky.social features tips on making a creamy nacho sauce as well as a guac that doesn't brown: cen.acs.org/food/food-sc...

🧪What a beautiful work has just been published. This study reveals the mechanisms behind egg release during ovulation. Looking at those images and videos is like visiting a museum. Pure art! 🔗 www.nature.com/articles/s41...

Picaña al gancho! Not many grilling days left this year...

“I quickly learned most undergraduates in my classes still hold the pre-Lewontin belief that human genetic variation predominately sorts geographically. Many students also thought race was based in genetic differences & that single mutations could explain complex traits in humans”

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Human prehistory [separate thread] 3.4: Ancient DNA: a genetic time capsule [this thread] web.stanford.edu/group/pritch...

The final program for the conference is now up: events.columbia.edu/cal/event/ev...

So cool!

A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree https://www.biorxiv.org/content/10.1101/2024.08.05.606142v1

Insights into non-crossover recombination from long-read sperm sequencing https://www.biorxiv.org/content/10.1101/2024.07.05.602249v1

Insights into gene conversion and crossing-over processes from long-read sequencing of human, chimpanzee and gorilla testes and sperm https://www.biorxiv.org/content/10.1101/2024.07.05.601967v1

Join the T2T consortium next Thursday, Apr 4, 12-4pm EDT for a webinar focused on the wet side of ultra-long read sequencing. We will have a half-day of seminars from top experts in the field sharing their advice plus a Q&A. Free and open to all. Register here: ucsc-seqtech-events.online

One of the perks of being at NIH! Peak blossom 🌸🌸!

Don't miss it if you are at TAGC!

A thread about how meiotic recombination is directed to the genome in vertebrates, discovered by studying corn snakes. Work with @choge.bsky.social, @mollyprz.bsky.social, and co-authors: 1/n

Bringing some meiosis to the genomic technologists big stage! :)

Putting reading glasses on...

Happy Summer Christmas! Feeling bad for the sweaty Santas...

Most of my favorite proteins in a single paper!

Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis https://www.biorxiv.org/content/10.1101/2023.11.07.566091v1

Our latest preprint, in which we show that genes involved in testis and sperm function have been released from the constraints of purifying selection in gorillas coincident with the origins of polygyny (thread to soon follow)…

A genome stability issue! to the To Be Read pile...🧪 www.cell.com/molecular-ce...

Great course, along with rafalab.dfci.harvard.edu/dslibro/ One of the few available resources in Spanish.