Telomeres stall DNA loop extrusion by condensin

Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports... In an exemplary in vitro/in vivo study, 1st authors ‪@btanalikwu.bsky.social‬ & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs! Great collaboration with Marcand lab.

Latest #CDlab paper online now: Cohesin supercoils DNA during loop extrusion www.cell.com/cell-reports... This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social‬) and single-molecule data (Richard Janissen).

Congratulations to the 2025 Schmidt Science Fellows - exciting that you'll be joining the community!!

We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes. Check it out and apply: ceesdekkerlab.nl/come-join-us/ RT=nice!

Huge congrats to our #CDlab PhD student @romanbarth.bsky.social for winning the prestigious 2025 Weintraub Award for his PhD thesis work on SMC motor proteins! www.fredhutch.org/en/news/rele... Great honor and well deserved Roman!

I'm excited to share that I've been selected as one of the 10 recipients of the prestigious Weintraub Award from @fredhutch.bsky.social this year! 🏆 I owe a massive debt of gratitude to the remarkable colleagues and mentors who have shaped my path, especially @ceesdekker.bsky.social !!

Check out this cool article by @newscientistnl.bsky.social on our latest work about direction-switching molecular motors racing along DNA: www.newscientist.nl/nieuws/eiwit...

Latest #CDlab paper now at @biorxivpreprint.bsky.social: www.biorxiv.org/content/10.1... In this paper, we identify two amino acid motifs on CTCF that impede cohesin-mediated DNA loop extrusion - important as CTCF and cohesin are crucial to the structure and regulation of our chromosomes.

CTCF stall DNA 🧬 loop ➰ extrusion by cohesin - but exactly how it pulls this off is a 'mechanistic mystery' (to cite @andersshansen.bsky.social, Nucleus, 2020). We just preprinted 📜 a new study @biorxivpreprint.bsky.social that provides some answers to this enigma: www.biorxiv.org/content/10.1...

Nice work from @romanbarth.bsky.social and all collaborators. It was exciting contributing to this work!

Very exciting new paper from @romanbarth.bsky.social @ceesdekker.bsky.social : cohesin is a one-sided extruded but it can switch direction with help from NIPBL

Check out Cees' fantastic summary of our most recent research!!

Exciting news 📃🧬🔬 Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in @cp-cell.bsky.social doi.org/10.1016/j.ce...

My first post! Hi science community 👋🧬 We have been trying to figure out the mechanistic mysteries about SMC motor proteins. They extrude our genome constantly into loops. We know that that's important. But how it works, is a matter of intense debate! Today, we report a piece of the puzzle: