(@davidasivak.bsky.social)

D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response D-SPIN is a computational framework for constructing mechanistically interpretable, generative models of cellular regulatory networks from single-cell mRNA-seq data. The framework models how perturbations change cell states by reconfiguring the underlying regulatory interactions, revealing global organization and key regulators of perturbation responses, as well as mechanisms of combinatorial drug responses. http://dlvr.it/TSVts8