How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

Be our new colleague! 🎉 The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor. 👉 More details here: lnkd.in/e8Z9eAm4 👉 Our department: mocel.unige.ch Please feel free to share this opportunity with your network.

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

“Just when you think you’ve seen it all, social insects reveal another surprise.” https://scim.ag/47sVFyS

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

Discovery happens less when you're trying to be the expert and more when you're trying to be the learner.

If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...

Our latest on brassinosteroid signaling: Ligand binding spectrum, specificity & selectivity of all BR receptors in Arabidopsis. By @albertocaregnato.bsky.social , @hmchen93.bsky.social and our great chemistry collaborators Mirek Kvasnica, Jana Oklestkova and Mirek Strnad.

We are searching for an enthusiastic scientist to join our team and establish annual killifish as a model system for early developmental biology and biophysics! @embl.org @embldbunit.bsky.social Apply here: embl.wd103.myworkdayjobs.com/EMBL/job/Hei... Please re-post 🙏

Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions rdcu.be/ezlhg

My colleagues Baptise Rafanel et al. investigated how a newly invading transposon can be silenced. They found that not only antisense insertions in piRNA clusters such as flamenco, but also insertions in the 3‘UTR of genes can drive potent silencing.

New method drop: HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning. www.biorxiv.org/content/10.1...

The Maria Leptin | EMBO Science Journalism Fellowships support life scientists pursuing a career in #ScienceJournalism and science journalists who wish to further their scientific education. Apply now: www.embo.org/funding/fell... #LifeSciences #funding 🧪

It was super fun working on this interview with Saanjbati Adhikari about my path during my scientific training.

Say hello to Florida's newest established species, Typhlonectes natans - the Rio Cauca Caecilian! You can read about their relative abundance, distribution, & natural history, in our brand new paper: journals.ku.edu/reptilesanda... Here is one individual I CT scanned that had 7 babies inside!

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

Postdoc positions available in the THJ group in Aarhus, Denmark 🇩🇰 Please share around 🤝

Yahoo! 🎉 Congrats Andi @pauligroup.bsky.social ! Super well deserved 😎

I may be biased by my career stage, but I don't understand how anyone can look at the European academia (DACH, particularly) and conclude that we need even more centralization of research.

📣 Ever considered applying for a ERC Starting Grant? The 2026 Call for proposals is now open! Application portal 👉 lnkd.in/dcsPAwqJ Information for Applicants 👉 lnkd.in/dsE6B8eE Deadline to apply for #ERCStG is 14 October 2025.

6/How we should do #science?

5/What’s #science

Read our preprint related to an important topic: climate change 👉 mr.copernicus.org/preprints/mr... As scientists, we rely on data for rational decisions. Climate science is clear: human-made CO₂ emissions are changing our climate fast. But what can we do about it—individually or as a community? 1/n

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply: mbg.au.dk/en/news-and-...

We are #hiring! Join the Bioinformatics Services team as a Staff Bioinformatician and contribute to our mission of advancing bioinformatics-driven research, built on cutting-edge computational infrastructure. Apply below!

We are #hiring! Join the Proteomics Tech-Hub as a Master’s Student and contribute to a project developing a low input & high throughput interactomics pipeline. Apply below!

www.bbc.com/news/article... 😔

Animal development requires #egg activation, which is initiated by calcium waves, but how does this happen? This study shows that protease activation of the Par2a receptor on the #zebrafish egg surface is required for successful #fertilization @plosbiology.org 🧪 plos.io/467nrzY

REFEREE 1: “I conclude with a simple, direct statement - this is the best paper I have read all year!” #TransparentPeerReview Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses @juliusbrennecke.bsky.social et al www.embopress.org/doi/full/10....

Planning to apply for #research #funding from the ERC? From the next application rounds, expect changes to the: • proposal structure • evaluation process • extra funding you can request • eligibility for Starting & Consolidator #Grants (from 2027) More 👇 europa.eu/!RPHWvv

To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals. For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq. www.biorxiv.org/content/10.1...

Easy, rapid and highly reproducible generation of translation-competent, cell-type-specific lysates from different human cells. #RNA #RNASky

Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators. www.science.org/doi/10.1126/...

Earlier this year, with Google DeepMind, we held the AlphaFold Education Summit to increase and strengthen global capacity through train-the-trainer sessions & the co-development of further #AlphaFold training. Now, we can share the free course materials with you: www.ebi.ac.uk/training/mat... 🧪🖥️🧬

I’m thrilled to share my very first first-author preprint and our lab’s latest work💫 We discovered a novel role for eIF2A in ribosome-associated quality control (RQC), challenging decades-old assumptions about its enigmatic function in translation initiation. Check it out to learn more! ⭐️ #RNA

www.cell.com/news-do/50-i... “I dream of a time when scientists take a deeper look at how societal norms deeply influence and also constrain the way we go about asking scientific questions. These norms manifest in the language (…), in the hypotheses we formulate, and in the choices we make”.

Delighted to share our newest publication - beautiful collaboration with Ya-Ming Hou’s lab. If you wonder whether bacterial mRNAs contain m6A (yes they do) and whether it matters (does not seem to) look here 👇🏻 academic.oup.com/nar/article/...

Hi 🦋 I’m thrilled to share that our #bat #organoid work has found a publishing home in Nature Immunology! These models provided unprecedented insight into antiviral immunity at epithelial surfaces of the Egyptian fruit bat 🦇 — a natural reservoir of Marburg virus 🦠 www.nature.com/articles/s41...

For all zebrafish folks - seems like there is finally a good/better zebrafish annotation! Check it out - and thanks to Shawn and his team for putting this together!

What a brilliant idea to bring together RNA and proteostasis research, and how lucky we were to host this meeting at our workplace! Thank you so much to the organizers - grateful to have contributed a small bit with some technical help!

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...

Same for ZFIN! @zfinmod.bsky.social put them in your papers' acknowledgements and cite them (Bradford et al. 2022 academic.oup.com/genetics/art...)

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

Congratulations @idajentoft.bsky.social ! I feel so lucky to be surrounded by so smart AND nice colleagues! Looking forward to learn more about embryonic diapause with you 🙂

Join the GMI as a Junior Group Leader! The GMI is seeking a talented scientist to lead an independent research group, addressing fundamental questions in molecular plant biology. More information is below.

I'm almost halfway through Night Science (I know, I'm so late on getting on this train). Apropos of absolutely nothing beyond their new logo, here are my top 8 favorite episodes from the first 30 installments of this gem of a podcast. @nightsciencepod.bsky.social nightscience.buzzsprout.com/1744020