Ben Heineike
@heineikeb.bsky.social
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Nice new paper by Mariella Obermaier in the Ralser Lab to understand interactions between common drugs co-administered with antifungals and antifungals on C. albicans
pubmed.ncbi.nlm.nih.gov/40720257/
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Non-antifungal medications administered during fungal infections drive drug tolerance and resistance in Candida albicans - PubMed
<span><b>Introduction.</b> Fungal infections are increasingly concerning, particularly in immunocompromised patients. These patients often suffer from comorbidities and receive multiple, non-antifunga...
https://pubmed.ncbi.nlm.nih.gov/40720257/
3 months ago
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Nice work by
@maxhaase.bsky.social
about the strange history of yeast centromeres - got to see him present it at
#yeast2025
add a skeleton here at some point
4 months ago
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Ben Heineike
Max Haase
7 months ago
It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
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Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
https://www.biorxiv.org/content/10.1101/2025.04.25.647736v1
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Ben Heineike
🧬Jacob L Steenwyk
4 months ago
NEW pub: The role of metabolism in shaping
#enzyme
structures over 400 million years. Now out in
@nature.com
Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!
www.nature.com/articles/s41...
#alphafold
#evolution
#genomics
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A paper I have been working on with Oliver Lemke in the Ralser lab has just come out:
www.nature.com/articles/s41...
We used predicted structures to gain insight into the evolution of metabolic proteins in yeast. A bit more in this linked-in post (
www.linkedin.com/posts/benjam...
).
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The role of metabolism in shaping enzyme structures over 400 million years - Nature
By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...
https://www.nature.com/articles/s41586-025-09205-6
4 months ago
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Ben Heineike
liti_nice
4 months ago
how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from
@melaniadangiolo.bsky.social
etal , with great help and insights from Eric Gilson, Jonas Warringer and
@juliamuenzner.bsky.social
(& Ralser lab)
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you reached the end!!
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