And unfortunately Wilcoxon remains what most people do in their standard scRNA-seq differential expression analysis between thousands of pseudoreplicates…

Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.

The protein concentration in the cytoplasm is so high that the average protein has a water hydration shell with a thickness of only ≈ 10 water molecules separating it from the adjacent protein hydration shell. 1/2

Excited to release the Consensus Pituitary Atlas, which brings a shared framework to process, annotate, and analyze single-cell datasets in the mouse pituitary. www.biorxiv.org/content/10.1...

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...

This Tuesday I attended the annual @londonomics.bsky.social symposium at the @crick.ac.uk , and presented a methods-focused version of some of the research I’ve done this past year.

We're still not finding any good evidence for a microbiome in any cancer type: see our new paper in @ScienceTM led by PhD student Yuchen (Peter) Ge www.science.org/doi/10.1126/... and the accompanying news piece, www.science.org/content/arti...

1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬 www.science.org/doi/full/10....

I had a great time presenting a poster of my research project at the Joint Congress of @esendocrinology.bsky.social and ESPE in Copenhagen.

Between serious research, our lab took some time out today for a fun hormone-themed activity. Endocrinology escape room- all about hormones! #BecauseHormonesMatter #WorldHormoneDay #pituitary #adrenal #endocrineresearch @esendocrinology.bsky.social @ese-eyes.bsky.social @pituitaryorg.bsky.social

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

The more jargon you have in your paper the less citations you'll get. royalsocietypublishing.org/doi/10.1098/...

David Baker talks about how the current uncertainty and instability hinder creativity because of the difficulty in thinking long-term. From this week’s Night Science Podcast nightscience.buzzsprout.com/1744020/epis... @nightsciencepod.bsky.social

I miss when the biggest controversy about mRNA was whether it correlated with protein or not.

Best lab with the best coffee mornings