Exciting #postdoc opportunity in KL Ung's group! Understanding the molecular mechanisms of cell wall remodeling in pathogens Learn more: shorturl.at/gPuFV Deadline: January 15, 2026 Contact: [email protected] #Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM

Excessive Ca²⁺ signaling fuels inflammation in a zebrafish model of #cysticfibrosis, and verapamil, an FDA-approved Ca²⁺ channel blocker, restores balance & limits inflammation, new study reveals. A promising repurposing opportunity for CF therapy! 📖 shorturl.at/Fxg9F ✍️ @sarahdja.bsky.social & coll.

Phages are not always fast-evolving chaos machines. In an oyster farm, Vibrio phages stayed genetically identical for 4 yrs, showing surprising viral stability shaped by nested ecology & mobile genetic elements. ✍️ @fredoleroux.bsky.social @epcrocha.bsky.social & coll. 📖 shorturl.at/Nq8G1 #MicroSky

tRNA-modification mutants in mycobacteria boost antibiotic recalcitrance by activating WhiB7 & coupling alanine metabolism to ribosome rescue and survival, new study reveals. ✍️ @jvaubourgeix.bsky.social & coll. 📖 shorturl.at/86JTs #MicroSky #AMR #RNAsky @imperialcollegeldn.bsky.social @inserm.fr

Staphylococcus aureus EVs are more than cargo carriers, they’re immune modulators. New work on MRSA N315 EVs reveals selective uptake, RNA release, and activation of TLR and NOD2 signaling. ✍️ Julia Papail, Eric Guédon & coll. @inrae-bzhndie.bsky.social 📖 shorturl.at/EuXh0 #MicroSky #Staphylococcus

New study suggests fetal brain vulnerability to Oropouche virus (OROV) in early pregnancy: Epidemic-related strain infects human neural progenitors & brain organoids, causing proliferation arrest, apoptosis & loss of brain architecture. #Virology ✍️ Alexandra Albert & coll. 📖 shorturl.at/nhO8F

New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky ✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll. 📖 shorturl.at/tuz6Q

Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org! It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance. Huge congrats to Wendy & colleagues! shorturl.at/WbFQC

Turns out even kings had ordinary mouths. A new study of King Richard III’s dental calculus shows his oral microbiome wasn’t so different from the common folk’s, despite a royal diet and lifestyle. #AncientDNA #Microbiome #MicroSky

Mycobacterium tuberculosis forms nitrate-induced intracytoplasmic membranes (MIMs) that rewire metabolism & dampen inflammation during infection, uncovering a new layer of bacterial adaptation! ✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr 📖 shorturl.at/9kbDM

We are looking to hire post-docs to work on T cell responses to M. tuberculosis infection using murine and NHP models. If you know T cells and wanna work on the top global infectious killer check us out. BSL3 experience not required. The NIH intramural program in Bethesda MD is an amazing place!

Streptococcus pneumoniae can induce competence via the ClpX/ClpP protease through the RipA toxin, which stresses replication and activates comCDE. Metabolically active but dying cells release CSP, spreading competence to neighbors. #MicroSky ✍️ @polardlab.bsky.social & coll. 📖 shorturl.at/E9ael

Listeria monocytogenes doesn’t just rush to the cytosol. It can replicate in permeated epithelial phagosomes lacking cathepsin D, where LLO sustains growth, PlcB drives escape, and the PrfA program is primed. ✍️ @alicelebreton.bsky.social & coll. @ibensens.bsky.social 📖 shorturl.at/1bFph

#Dengue virus slips infection-boosting RNAs into mosquito saliva by hitching a ride in EVs, a study finds. The viral RNA hooks onto a mosquito protein, AeSyntenin, to get packaged and released. #MicroSky #Virology ✍️ @julienpompon.bsky.social & coll. @ird-fr.bsky.social 📖 shorturl.at/lxUyw

A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon research.pasteur.fr/en/job/a-two...

New study reveals a CD38-like ADP-ribosyl cyclase toxin delivered by T6SS that depletes NAD+ in both bacterial and eukaryotic cells. A striking case of structural mimicry, cross-immunity, and widespread deployment in microbial warfare. ✍️‪ @jmartinkus.bsky.social & coll. 📖 shorturl.at/b5LSB #MicroSky

We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested: emploi.cnrs.fr/Offres/CDD/U...

A new study delivers the most comprehensive phylogenomic analysis of Spirochaetes to date, revealing their deep evolutionary roots and shedding light on the loss of spiral morphology and host adaptation. ✍️ @microbiomol.bsky.social and coll. @pasteur.fr 📖 shorturl.at/UxAWu #MicroSky

E. coli and P. aeruginosa need the Hsp90 chaperone to produce key virulence factors colibactin & pyoverdine, study reveals. Hsp90 stabilizes megasynthases behind complex metabolite biosynthesis. New angles on infection control & biotech tools! 📖 shorturl.at/n1Pu6 ✍️ Fratacci, Chaouche & coll. #IMM

New insights into Shigella flexneri pathogenesis: the VapBC TA system is activated during intracellular infection, coordinating stress adaptation, T3SS-mediated virulence, and immune evasion, new study reveals. ✍️ E. Saifi & coll. @inem-necker.bsky.social @pasteur.fr 📖 shorturl.at/26d33 #MicroSky

A new path in the fight against AMR! Using B cells from CF patients, researchers isolated human mAbs targeting the T3SS of P. aeruginosa. Structural & functional data reveal distinct neutralization modes, blocking virulence without antibiotics! #MicroSky ✍️ ‪JM Desveaux @ coll. 📖 shorturl.at/2hixd

A prophage-encoded single-stranded DNA-binding protein (SSBP) from S. aureus attenuates bacterial virulence and enhances macrophage activation via IL-6, new study reveals. SSBP boosts immune clearance and shows therapeutic potential. #MicroSky #Phage ✍️ Ahmad-Mansour & coll. 📖 shorturl.at/6yqFx

Dynamic excision of the F13 hlb-converting prophage in Staph. aureus is critical for full virulence, new study reveals. Loss of F13 restores β-hemolysin expression and enhances pathogenicity, while locking the prophage impairs infection. #MicroSky ✍️ O. Poupel & coll @pasteur.fr 📖 shorturl.at/F1W3t

Uropathogenic E. coli uses a novel two-gene system, DanRI, to outsmart neutrophils by blocking NETs and ROS. Induced by host nucleosomes, DanRI boosts bacterial survival & persistence. A new twist in immune evasion! ✍️ @doracerina.bsky.social & coll. 📖 shorturl.at/cAj05 #MicroSky

Nearly half of bacteria carry mobile, accessory PDF enzymes that can resist actinonin, new study reveals. Resistance to PDF-targeting antibiotics is already encoded and poised to spread. #AMR #MicroSky ✍️ @morgan-lamberioux.bsky.social and coll. @pasteur.fr 📖 shorturl.at/WTBVx

New study reshapes our view of sleeping sickness: #Trypanosoma brucei persists in fatty skin tissues and uses host-derived glycerol to get transmission-ready, even when blood levels are low. #SleepingSickness #ScienceNews #Parasites ✍️F. Bringaud & coll. 📖https://shorturl.at/LGGxk

Antibiotics disrupt gut microbes, but what about their viruses? A new study finds that gut phages crash, bloom, and bounce back after antibiotics, helping restore microbial balance via kill-the-winner dynamics. ✍️ @eugenpfeifer.bsky.social & coll. 📖 shorturl.at/AtafX #MicroSky #AMR

🚨My new team at @ipbstoulouse.bsky.social in France currently have an open, fully-funded PhD position 🧑‍🔬👩‍🔬to study membrane proteins & transporters of therapeutic interest using cryo-EM & biophysics.🧊🔬🦠 #StructuralBiology #MicroSky Please share 🤝 For more details 👇

I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!

New study reveals that Salmonella can replicate inside macrophages even without its T3SSs, if the nutrient conditions are right! Metabolic heterogeneity of host cells is a game-changer in bacterial replication dynamics. #MicroSky ✍️ @pescoll.bsky.social and coll. @pasteur.fr 📖 shorturl.at/a9a06

Why did Omicron dominate the #COVID19 waves? New study reveals: Faster replication in human nasal tissue, Disruption of motile cilia & Stealthy evasion of innate immune defenses Omicron wasn’t just fast, it was sneaky! ✍️ @lisachakrabarti.bsky.social and coll. @pasteur.fr shorturl.at/ByGOh

Happy to share Saurabh's latest review on the bacterial exometabolome and its role in virulence and pathogenesis, just out in @cp-trendsmicrobiol.bsky.social — and it’s open access! 😉 👏 @saurabhchugh09.bsky.social www.cell.com/trends/micro...

New study reveals how segmented filamentous bacteria attach to the gut lining: a unique tip structure on their intracellular offspring is key! Cryo-EM shows a novel S-layer transition at the tip, critical for immune-boosting host interaction. #Microsky 📖 shorturl.at/gXueL ✍️ P. Schnupf and coll.

New study reveals how NCOA7-AS helps block flu virus entry by teaming up with V-ATPase and SNX5/6. Key mutations break this defense, offering new insight into how cells fight infection. ✍️ M. Arnaud-Arnould, @arebendenne.bsky.social, @mickael-blaise.bsky.social, C. Goujon & coll. 📖 shorturl.at/q2uYb

In the Thau lagoon, free-living amoebae show distinct habitat patterns and selective grazing on Vibrionaceae, new study reveals. A complex, underexplored microbial ecology! ✍️ @gm-charriere.bsky.social & coll. 📖 shorturl.at/fWnuM #MicroSky #MicrobialEcology #Protistology

Another PhD Position in my lab - phage therapy - programming skill required. Open for international candidates

New study shows HlyF/CprA enzymes enhance OMV-mediated virulence in E. coli and P. aeruginosa by promoting direct membrane fusion and clathrin-independent uptake. A novel mechanism for efficient cargo delivery and host manipulation. #MicroSky ✍️ @ericoswald.bsky.social & coll. 📖 shorturl.at/zpNYl

New study reveals that E. coli LdcI filamentation under acid stress enhances pH buffering and fitness. Disrupting polymerisation impairs enzyme clustering and stress response, highlighting self-assembly as a key regulatory mechanism. #MicroSky ✍️ M. Kirchner, I. Gutsche & coll. 📖 shorturl.at/am3Pu

🚨 Save the date! The Annual Congress of the French Society for Microbiology is heading to Bordeaux, Sept 24–26, 2025! An unmissable event for all microbe lovers. 🗓 Full program here 👉 shorturl.at/R1cwa #SFM2025 #Microbiology #MicroSky @sfmicrobiologie.bsky.social

🦠 Streptococcus gallolyticus & colorectal cancer: Genome sequencing of 35 clinical isolates reveals unexpected genetic diversity, antibiotic resistance & key virulence factors for gut colonization. No CRC-specific pathogenicity island, but a powerful surface protein arsenal! shorturl.at/6qyiQ

The lung opportunist A. xylosoxidans is not just a bystander, it hacks P. aeruginosa's virulence! One strain (Ax 200) tames P. aeruginosa by disrupting biofilms, motility & iron metabolism. First in vivo proof of this microbial rivalry! #Microbiome #CF #InfectionBiology #MicroSky shorturl.at/cm49w

Thrilled to share the last work from the lab! Generating a mycobacterial strain lacking all T7SS and studying the contribution of ESX-3 and ESX-4 in M. abscessus pathogenesis. Great collab with E Tocheva and JL Herrmann. rdcu.be/d8uHH

A previous study showed that a single Trypanosoma slender form can infect young tsetse flies. But how does this compare to stumpy forms in immune adult flies? 🦟🩸 Scientists found that while slender forms rarely establish infections, stumpy forms are far more efficient. @pasteur.fr shorturl.at/RXkVB

CprA, a conserved SDR protein, drives P. aeruginosa virulence by boosting OMVs, blocking autophagy, and fueling immune evasion. Found in E. coli, Y. pestis, & more. New target for tackling deadly infections! 🔬💥 #AMR #MicroSky ✍️ @priscillabranchu.bsky.social E. Oswald & coll. shorturl.at/LgedS

Mycoplasmas swap genes more than we thought! New study shows that conjugation in M. agalactiae thrives in the presence of eukaryotic cells, boosting mating rates & ICEA transfer. Even M. bovis gets in on the action! Could HGT in vivo be underestimated? #MicroSky ✍️Baranowski & coll. shorturl.at/1GFUZ

New research shows half of 53 tested #Staphylococcus species can sneak into osteoblasts using the FnBP-fibronectin-α5β1 integrin pathway, just like S. aureus! #MicroSky ✍️ @flaurent-lyon.bsky.social @bone-jj-infect.bsky.social and coll. shorturl.at/PS9RQ

Bacteria’s secret weapon! T6SS is not just ON or OFF, it’s a clonal battlefield strategy. Some cells attack, others survive, all in a stable equilibrium controlled by iron, methylation & genetics. A perfect trade-off for polymicrobial warfare! ✍️ @cascaleslab.bsky.social & coll. shorturl.at/uq2uH

Santé et changement climatique. Une mystérieuse maladie cutanée a frappé plus de 1000 pêcheurs sénégalais en 2020-2021. Des chercheurs de l’IPBS et leurs collègues révèlent enfin la cause dans @embomolmed.org : une toxine d’une microalgue marine déclenche une inflammation sévère. shorturl.at/VCcRg

In 2020-21, a strange skin disease struck 1,000+ Senegalese fishermen. Now, IPBS researchers & colleagues reveal the culprit in @embomolmed.org: the toxin Portimine A from the microalga V. rugosum. A warning on rising environmental threats! #MicroSky #Toxins #ClimateChange 🔗 shorturl.at/SNkzY

Evolution at work! In just 640 generations, E. coli under competition lost its T6SS nanoweapon via adaptive mutations. A novel RfaH-dependent regulation was uncovered, hinting at a conserved control across enterobacteria. #T6SS #MicroSky ✍️ Cascales and coll. www.biorxiv.org/content/10.1...