𝐇𝐨𝐰 𝐝𝐨 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐚 𝐭𝐮𝐫𝐧 𝐡𝐨𝐬𝐭 𝐬𝐭𝐫𝐞𝐬𝐬 𝐢𝐧𝐭𝐨 𝐯𝐢𝐫𝐮𝐥𝐞𝐧𝐜𝐞 𝐩𝐫𝐨𝐠𝐫𝐚𝐦𝐬? A new study in @natcomms.nature.com shows that Fe-S cluster damage activates the stringent response in 𝑆𝑎𝑙𝑚𝑜𝑛𝑒𝑙𝑙𝑎, 𝐸𝑛𝑡𝑒𝑟𝑜𝑏𝑎𝑐𝑡𝑒𝑟 and 𝐾𝑙𝑒𝑏𝑠𝑖𝑒𝑙𝑙𝑎. ✍️ @sronneau.bsky.social & coll. 📖 shorturl.at/zP3BB #Microbiology #StringentResponse #ppGpp

Happy to share our lastest story about the Stringent Response ! We show how host-relevant stress disrupts Fe-S cluster stability, tuning (p)ppGpp levels to control bacterial adaptation and trigger virulence. Read more here 👉 www.biorxiv.org/content/10.1...

Excited to share our latest work on antibiotic persistence ! We found that while bacteria intoxicated by host RNS are shielded from β-lactams, they still remain vulnerable to fluoroquinolones. Why? Check our new study : journals.plos.org/plospathogen...

The HintonLab SalCom transcriptomic databases are back on online TODAY❗️#Salmonella SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack

Highly recommend this excellent review from Katherine Cotten and Kimberly Davis about antibiotic persistence during infection. Really happy to see that we are moving forward in this challenging field !