New preprint. In S. sanguinis, a C5a peptidase-like protease (ScpH) polymerizes along eDNA, turning it into a catalytic biofilm scaffold. Great work from @robinanger.bsky.social in our lab, with Pelicic lab @lcbofficiel.bsky.social www.biorxiv.org/content/10.6...

Deadline approaching: Submit an abstract until 12th of May to present at the UK Cellular Microbiology Meeting 2026! Great opportunity for early career researchers! www.ukcellmicro.org

🧵 Tiny organisms, big advantages!

Don’t miss out on More Questions of Science. We’ve recorded six bonus episodes, revisiting some of the biggest themes from previous episodes of A Question of Science Listen to all six brand-new episodes on your favourite podcast platform: www.lnk.to/AQuestionOfScienceBB

We’ve been sciencing! M abscessus makes a arabinanase toxin to chop up the cell wall of competitor mycobacteria! #glycotime 🦠 thanks to @wellcometrust.bsky.social for the funding that makes this collaborative work possible! Also Sam’s structures are 😍 and Jean-Lou did some lovely biochem

We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy? Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation. www.nature.com/articles/s41... (1 out of 3)

“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

🧬 EMBO Workshop – The complexity of mycobacterial infections: from research to real-world impact 📅 14–18 Sept 2026, Paris Tuberculosis & non-tuberculous mycobacteria at the heart of discussions: evolution, host–pathogen interactions, drug resistance. 🔗 meetings.embo.org/event/26-myc...

You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database. This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list. www.ebi.ac.uk/about/news/t...

I’m pleased 🤗 to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) 💊 Thanks to everyone who have participated 🙌 We hope these findings will help the fight against drug resistance in tuberculosis. www.biorxiv.org/content/10.6...

I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...

⏰️ Missed the deadline to submit? Don't worry! 🙌 Our Call for Papers on Host-Pathogen Interactions has now extended to 11 March 2026. 🦠 Take this extra time to submit your work on host-pathogen communications/interaction, pathogen tolerance and resistance mechanisms ➡️ buff.ly/NwTaoan

Happy to share a new review proposing a unified nomenclature for T4SSs. Great collaboration with Peter J Christie, Gabriel Waksman, Ronnie Per-Arne Berntsson and our team. academic.oup.com/femsre/artic... #T4SS#Microbiology

1/📢 In our new publication, we estimate that in 2022, 134 million people worldwide had a recent Mycobacterium tuberculosis (Mtb) infection and were at high risk of progressing to TB disease. Read the full paper in PLOS Medicine (tinyurl.com/mtbinfection). #TBSky

🚨 New preprint! Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬 Check it out: doi.org/10.64898/202...

Unveiling hidden variables in stressed bacteria: Cell Reports www.cell.com/cell-reports...

#Microbiology The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear Here the authors clarify how bedaquiline works @jnblab.bsky.social @morwan.me #TBSky #antibiotics #AMR http://dlvr.it/TQjZ0W

🔬UK researchers: Access cutting-edge bioimaging tech + expert support with our User Access Fund! 💷 £5k for imaging 💷 £2k for image analysis Choose from 6 top UK facilities, contact them, then apply! rms.org.uk/user-access-fund ⏰ Next deadline: 31 March ✅ Decision in 4 weeks Pls share!

Throughout the year, our community has been sharing stories with us about how The Company of Biologists has supported you over time. Your stories were heartfelt, and we feel grateful and humbled that we have been able to be part of your journeys. bit.ly/4q7C0Ki

How do you react when your favorite microbe is renamed by taxonomists who are completely outside your field—and who ignore the community that actually works with it? Here is our clear answer re the case of Pseudomonas putida KT2440 👉🏻 journals.asm.org/doi/10.1128/...

Join us in Amsterdam for a FEBS advanced course on "Functional Imaging of cellular dynamics" from 31st of May - 6th of June 2026 Info: microscopy2026.febsevents.org

We are looking for a new RA to join our team working on host-pathogen interactions during Salmonella infection. The appointment is for two years and you will join a diverse team, using cell and protein biochemistry to further our understanding of pathogenesis. my.corehr.com/pls/uoxrecru...

📯👨‍🚀 Calling all #bioimage analysis aficionados. #EZInput is out! We wanted to bring #ImageJ’s capacity to record settings to the #Python ecosystem 🐍. It is a declarative library for generating UIs that just work. Done with @guijacquemet.bsky.social lab arxiv.org/abs/2601.08859 #ScientificComputing

🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰. ✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social 📖 shorturl.at/IDwza 👇 A short thread...

Journal of Cell Science @jcellsci.bsky.social is recruiting an enthusiastic and motivated Reviews Editor. An exciting opportunity for a talented scientific editor to make a contribution to an important journal in the field of #cellbiology. Deadline 2 Feb. More at: www.biologists.com/about-us/wor...

🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection? Check out our latest paper published in Science Advances 👇 www.science.org/doi/10.1126/... ✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨

To accelerate the publication process, @biologyopen.bsky.social are testing an initiative that prioritises fast but fair peer review. This approach pays reviewers while requiring them to complete high-quality reviews in a set timeframe. Apply to be a reviewer www.biologists.com/bio-fast-and...

We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.

Two pieces of fun news: 1. We've launched a new website for our lab: www.brysonlab.org 2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!

As my own three year stint as an Editor comes to an end I cannot recommend doing this enough

I'm not sure what to think about this. Most top open access journals cost more than CHF 3,500 to publish so will not be covered by SNSF funding. It will make it even more difficult for small universities to publish in top journals because of budget limitations.

How do simple cells make complex patterns? We discovered a key piece in cyanobacteria—an ancient enzyme repurposed to activate a pattern-forming signal. A conserved signaling strategy, showing how nature reuses tools to build multicellularity. www.cell.com/iscience/ful...

🚨PhD position alert🚨 🔬Cryo-EM? ✅ 🧫Membrane proteins? - we've got 165 TMs for you! ✅ Join me and the team👥 in beautiful Amsterdam🚴 to untangle the amazing mycobacterial protein secretion machinery! 📝Apply here: tinyurl.com/mmxnfpnw 📆Deadline: 23 January #PhDstudent #T7SS #cryoEM #newPI

Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems 👉 buff.ly/XjXUefA #Mycobacteria #Tuberculosis @pierresantucci.bsky.social

Really honoured and grateful to have received the Laemmli Prize ✨ A wonderful recognition of my PhD work @sciencesunige.bsky.social in the @soldatilab.bsky.social

Stay tuned in the coming weeks to learn more about Angélique's work 👀

🏆 It's a double win for the Soldati Lab! Last Friday, our former PhD students @angieprrt.bsky.social and Jahn Nitschke each received an award for their doctoral work: the Laemmli Prize for Angélique and Best Thesis in Life Sciences for Jahn. So proud of both for these well-deserved honors! 🤩

Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies. journals.plos.org/plospathogen...

Are you interested in cytoskeleton and looking for a postdoc position? I will be advertising positions in the new year but happy to chat in person if you are attending ASCB @ascbiology.bsky.social in Philadelphia. Just drop me a line.

🚀 Latest paper form the lab is now out at @febsopenbio.bsky.social @febspress.bsky.social 🔵⚪🔴 We use CRISPRi tools from the @rocklabtb.bsky.social to target essential genes and control smooth to rough transition in M.smegmatis & M.abscessus 🦠🧫👇👇👇 febs.onlinelibrary.wiley.com/doi/10.1002/...

if you are interested in a PhD in tuberculosis drug discovery, check out our opportunities 🧪🦠 #Tuberculosis lstm.ac/PhD

Editorial: Society journals matter—supporting science through renewed commitment Editorial in @femsjournals.bsky.social microLife by @paulbrainey.bsky.social and colleagues academic.oup.com/microlife/ad...

📢 Early-Career TB Researchers: Submit short talk abstracts & scholarship apps by Nov. 24! Join us Mar 23-26, 2026 in Cape Town for cutting-edge TB & global health. 🎥Highlights: youtu.be/YcKVeGWqXSM Submit: keysym.us/KSTB26 @maxgg.bsky.social @breealdridge.bsky.social #KSTB26 #tuberculosis #TB

Our latest T7SS study is now out in Science Advances! We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery. www.science.org/doi/10.1126/...

Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology. www.nature.com/articles/s41...

Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/... This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070

Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet 🗓️13-18 September 2026 📍Sant Feliu de Guixols, Spain 📝Program and registration info: meetings.embo.org/event/26-bac... 👩‍🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social #MicroSky

Expanding the scope of Mycobacterium abscessus reference strains to improve pulmonary disease modeling https://www.biorxiv.org/content/10.1101/2025.11.19.689313v1