Coup de projecteur sur des projets en rupture et à haut risque du programme EXPLOR’AE ✔️39 idées exploration et 5 projets transformation déjà financés #France2030 Des hypothèses originales pour des innovations de rupture, des recherches qui sortent des sentiers battus ! url.inrae.fr/44ySyng

#AMR Nice summary of the new hope www.thevermilion.com/why-could-a-...

New antibiotic class discovered by researchers at @mcmasteruniversity.bsky.social & @illinoispress.bsky.social "A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome" in @nature.com Hope it can make it to market to help combat #AMR infections www.nature.com/articles/s41...

We are looking for a postdoc! Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria! Please share! www.nature.com/naturecareer...

www.nature.com/articles/s41... In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements. #phage #plasmid #evolution #bacteria #plasmidbiology #MGE

Exited to start the T4SS conference. www.t4ss-conference-nancy.org

We organize the french EPR society meeting at the @iecb.bsky.social in Bordeaux. Registration are due soon! More info here : www.a-rpe.fr/spip.php?art...

Exciting to see our paper now published 🙌 www.science.org/doi/10.1126/... In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇

Exciting stuff! will be interesting to test this on our own favourite protein ensembles!

Well, this is silly. Clarivate won’t give @elife.bsky.social an impact factor, citing quality concerns with their model, but happily does so for partially predatory journals like those within MDPI? www.science.org/content/arti...

New review from our C. Lesterlin/TacC lab ! 🌟 The potential and limitations of conjugation-based antibacterial strategies. doi.org/10.1111/1751...

Re-sharing our last paper on the effect of restriction-modification systems on conjugative plasmids: doi.org/10.1093/nar/... #MicroSky

And finally, a recent review we wrote speculating on the evolutionary aspects of MGEs mobilising chromosomal DNA

The contribution of natural transformation for the acquisition of novel genes has been notoriously difficult to quantify because it relies on recombination (which is affected by other processes). Here's a first estimate : doi.org/10.1101/2025... (for the very busy: 1-6% of gene gains) #MicroSky

Happy to see this story out! Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs | Science Advances www.science.org/doi/10.1126/... Thanks to all colleagues and collaborators! With support of INRAe, Université de Lorraine and ANR.

We are very pleased to share our latest preprint on the architecture of the membrane complex of the type 7 secretion system involved in bacterial competition in B. subtilis. #CryoEM #microsky