Visit PDB-101 to learn more about Antimicrobial Resistance

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Archaea are often surrounded by bacteria. But is there ever active conflict between the two? Can archaea kill bacteria? If so, how do they do it? Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...

Interesting that they could put a number on it. And yes, that's a reindeer seeking shade behind a concrete wall. Not their usual place to hang out...

Cryo-EM ligand building using AlphaFold3-like model and molecular dynamics pubmed.ncbi.nlm.nih.gov/40788932/ #cryoem

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve. Preprint 📝: biorxiv.org/content/10.1... 🧵 1/n

😳😱 not a smart move…🧬🧶

I'm today starting as pro-dean at the medical faculty at @umeauniversitet.bsky.social. Looking forward to exciting years ahead, together with the new dean Katrine Riklund and the others in the faculty leadership!

Finally! ERC is reducing the length of part II of their application form. 'The length of this section is now limited to seven pages for Starting, Consolidator, and Advanced Grant applications and ten pages for Synergy Grant applications'

Alltid lika spännande att se vilka som blir nya ledamöter i @sverigesungaakademi.se! Är lite extra glad över att se att vi får en ny lokal ledamot, då @laurabacete.bsky.social från Umeå @umeaplantsciencecentre.se / @umeauniversitet.bsky.social är invald 🙂 sverigesungaakademi.se/pressmeddela...

Bra tråd om man är intresserad av skog!

"Science is an investment. We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world." — President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷

What can one say.. www.nature.com/articles/d41...

Only 5 more days left to apply. Take the chance and join us trying to understand the molecular mechanisms of conjugation, in beautiful Umeå, Sweden. We are extremely well equipped, and are looking for an enthusiastic person to join our team! 😀

This is cool stuff, will be interesting to try out!

These gender studies lectures are just writing themselves

HULK ADAM SMASHES DIRE WOLVES. Man alive this vexes me, and I am a bit sweary and irritable in this. Enjoy. arutherford.substack.com/p/dire-wolve...

Maybe not completely research related, but if you do apply and end up getting the position, you can look forward to great displays of northern lights, like this one yesterday (taken from my yard with my cell phone camera..)

If having a negative personal opinion of the policies that are now severely affecting researchers in the US is grounds for not being let in the country, it seems like I'll be skipping any US conferences the coming years... www-lemonde-fr.translate.goog/internationa...

Well written!

🚨This week, many Columbia scientists lost grants that funded over half their annual income. Others will no longer be able to do research that helps treat thousands of sick patients across the US. "It hurts," they told me. My story for @nature.com 🧪 www.nature.com/articles/d41...

We are looking for a postdoc! Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria! Please share! www.nature.com/naturecareer...

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

A bizarre new development that even further decreases academic freedom in the US! www.nature.com/articles/d41...

Ukraine is Europe! We stand by Ukraine. We will step up our support to Ukraine so that they can continue to fight back the agressor. Today, it became clear that the free world needs a new leader. It’s up to us, Europeans, to take this challenge.

Current policy in the US is bad for science in the US, but also globally, on a whole multitude of levels. Even if one politically wants to decrease national funding on research, then this is clearly not the smart way of going about doing that. www.nature.com/articles/d41...

Another beautiful morning in Umeå! Sun is shining, we have a crisp -10°C, snow everywhere. Just perfect 😍❄️☀️

Come join us here in the north! Remarkably good research climate, infrastructure and colleagues. Further, the Swedish government is doing a reasonably good job of putting money into research funding instead of cutting it as is happening in some other places!

We are incredibly happy for @endymiomatic.bsky.social who managed to secure a Marie Curie Sklodowska Actions postdoc grant for further work in our group! Congrats Kieran!

Sveriges unga akademi lanserar Forskningsfyren - pris för forskningskommunikation. Känner ni någon yngre forskare som har gjort bra insatser för att kommunicera forskning så håll koll på detta, det är möjligt att nominera från 10 februari! sverigesungaakademi.se/pressmeddela...

Foldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects. 📄 nature.com/articles/s41... 🌐 search.foldseek.com

europepmc.org is the European (and better) version of Pubmed if the latter goes down due to fragile state reasons.

This will probably generate some backlash since there are important environmental, commensal, and pathogenic species in each group, but Gram-positive bacteria are just more talented, rather more charismatic, and simply better looking than Gram-negative bacteria

7 days left to apply!

2024 daily temperatures compared to past years. A frightening graphic from the BBC. #ClimateEmergency

I am happy and honored to have been entrusted with the role of Deputy Dean for the Faculty of Medicine at Umeå University, starting July 1, 2025. It will be extremely interesting to take on this new role, together with the incoming Dean, Katrine Riklund!

It’s not that often that one publishes an article on New Year’s Eve! Enjoy reading about Gram-positive Type 4 Secretion Systems, and Happy New Year! 🎆🎊 www.sciencedirect.com/science/arti...

Just got an early Christmas present as our recently resubmitted article just got accepted! 🙂

Fully agree!

Ett samhälle som orienterar sig efter osanningar kommer undantagslöst att gå vilse. Forskare, akademiker och experter kan inte lämna walkover när den faktabaserade världsbilden angrips. Vi har ett ansvar att förklara komplexa fenomen för allmänheten. www.dn.se/sverige/fars...

Nu missförstår forskare vad jag säger här och tror jag uppmanar de till att prata om sin egen forskning. Det är good and well att göra det, men inte det jag efterlyser. De allra flestas forskning är ultraspecialiserad och saknar därmed stort allmänintresse. Men! ->

We updated our BindCraft preprint with lots of new exciting results! We release all our binder sequences and models, include more in silico analysis, novel design targets, and present AAV retargeting to specific cell types using de novo binders! www.biorxiv.org/content/10.1...

Well, this is silly. Clarivate won’t give @elife.bsky.social an impact factor, citing quality concerns with their model, but happily does so for partially predatory journals like those within MDPI? www.science.org/content/arti...

Interested in structural biology, biochemistry and Type 4 Secretion Systems? 🦠 🧬 🧪 We are recruiting a postdoctoral fellow! - Deadline 28th of January, 2025 - 2 year fellowship - Details and application link: tinyurl.com/48djw6k3 - Contact me for questions! Please repost! 💙

Exciting stuff! will be interesting to test this on our own favourite protein ensembles!

The 300th (!) installment of Molecule of the Month explores newly-revealed atomic details of one of the wonders of the biomolecular world: the Flagellar Motor pdb101.rcsb.org/motm...

OK, this is just a damn cool article 🤯 🦠 🔬 Infecting the cell nucleus, gaining nutrients, but preventing cell death! www.nature.com/articles/s41...

Our lab was just awarded funding from hashtag#Kempestiftelserna 🎉🍾 Thank you for this!

Check out our new preprint on PrgK, the cell-wall degrading enzyme of a Gram-positive Type 4 Secretion System that transports #antibiotic resistance genes and other #virulence factors. #AMR With @rberntsson.bsky.social , Wei-Sheng Sun, Gabriel Torrens & Felipe Cava. www.biorxiv.org/content/10.1...