#Microbiology The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear Here the authors clarify how bedaquiline works @jnblab.bsky.social @morwan.me #TBSky #antibiotics #AMR http://dlvr.it/TQjZ0W

Congrats @tobinlab.bsky.social!

Many of you in the mycobacterial community attended the awesome inaugural 2025 Biology of Mycobacteria GRC, organized by @heran.bsky.social and myself: www.grc.org/biology-of-m.... I am writing with an update about this conference as the new chair.

Check out our exciting new paper out now in @plos.org where Dr Ahmad manipulated #peptidoglycan chemistry to understand Lyme disease and arthritis 👇👏 #Microsky #glycotime journals.plos.org/plospathogen...

I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...

Congrats @regolab.bsky.social! www.pnas.org/doi/10.1073/...

The Barber lab is looking to hire post-docs to work on #tuberculosis #immunology using murine and NHP models. BSL3 experience not required. Check out our lab in the NIH intramural program in Bethesda MD!

A study in @science.org from Paul Cohen's lab, led by @maschakoenen.bsky.social, demonstrates how beige fat directly influences blood pressure. The findings offer a new target for treating vascular disease and could lead to more precise therapies for hypertension: https://bit.ly/4pK0hGh

We are hiring new faculty!! Come join our amazing community in the Department of Molecular Microbiology at Washington University School of Medicine! The deadline for applications is 2/21, but applications will be reviewed on a rolling basis. facultyopportunities.wustl.edu/Posting/Deta...

Congrats @maxgg.bsky.social and team! This looks very cool.

Lab-grown lung models have traditionally been grown from a mixture of cells, making it hard to tell how a disease or treatment will affect an individual person. These new models by @maxgg.bsky.social’s team and AlveoliX are grown from a single person’s stem cells ⤵️ www.crick.ac.uk/news/2026-01...

The @ragoninstitute.bsky.social is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks! #immunosky www.nature.com/naturecareer...

Congrats Luiz and colleagues. Important work!

While everyone is hustling for the holidays, hopefully folks will have time to submit abstracts or register for #ASMMicrobe2026 in DC! Please repost!

We’re heading for one thousand ⭐️ signatures today! Thank you to all who have signed and shared so far, Still plenty of other people to reach before we all wrap up for the holidays, so send family and friends the petition link as an early resolution for a happier New Year! c.org/rstb5XTvns

Two pieces of fun news: 1. We've launched a new website for our lab: www.brysonlab.org 2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!

🚨 𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐫𝐨𝐦 𝐨𝐮𝐫 𝐥𝐚𝐛, 𝐚𝐧𝐝 𝐚 𝐟𝐢𝐫𝐬𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐓𝐁 𝐟𝐢𝐞𝐥𝐝! 🚨 We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses. 📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9

Congrats to @alercher.bsky.social of the #RiceLab, who has won the 2025 Sidney & Joan Pestka Post-Graduate Award from the @cytokinesociety.bsky.social#RiceLab

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies. journals.plos.org/plospathogen...

Hey friends. I’m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me [email protected]. Thanks!

Antibiotic resistance mutations boost bacterial fitness in the presence of drug but can decrease fitness in its absence. We & others showed that the fitness cost of the most common rifampicin-resistance mutation in M. tuberculosis stems largely from excessive transcriptional termination.

🚀 Latest paper form the lab is now out at @febsopenbio.bsky.social @febspress.bsky.social 🔵⚪🔴 We use CRISPRi tools from the @rocklabtb.bsky.social to target essential genes and control smooth to rough transition in M.smegmatis & M.abscessus 🦠🧫👇👇👇 febs.onlinelibrary.wiley.com/doi/10.1002/...

New research from Rockefeller's Michel Nussenzweig and colleagues finds one particular class of immune cells appears to play a crucial role in achieving a functional cure among people with HIV. #worldAIDSday

New Rockefeller research from Michael Rout and Brian Chait finds that nuclear pore complex (NPC) machinery is an extraordinarily dynamic system, offering new insights into diseases such as #cancer and #neurodegeneration that are linked to NPC breakdown: https://bit.ly/3KAlrIk

If you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.

Rockefeller researchers Shixin Liu and Joel Cohen reveal how key regulatory proteins work in a precise hierarchy to meticulously adjust pacing during transcription.

Cells stop dividing when telomeres become too short, a process known as replicative senescence. A new study from the #deLange lab reveals what drives this, and why cells senesce far earlier under high-oxygen conditions versus low-oxygen ones.

Sign the petition for more research funding across New York State - and share with your friends…

Exciting collab with Paul Palme, Peter Imming, & Adrian Richter! Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f #MedChem #TB #NTM pubs.acs.org/doi/full/10....

📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW

Sharing this article that I wrote with my husband, @jutraslab.bsky.social for @unbiasedscipod.bsky.social. Last week researchers reported what appears to be the first clearly documented fatality from alpha‑gal syndrome. #Scicomm #tickbornediseases #alphagalsyndrome

Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology. www.nature.com/articles/s41...

With the Wilmanns lab @embl.org we reveal cryoEM structures of an essential, bifunctional acyl-CoA carboxylase from mycobacteria. @wertheimufscripps.bsky.social This ~ 600 kDa enzyme is asymmetric, rotatory, has unusual stoichiometry, and unique E5 subunits. www.biorxiv.org/content/10.1...

#microsky The phenotypic landscape of the mycobacterial cell www.biorxiv.org/content/10.1...

Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): www.biorxiv.org/content/10.1...

📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate. apply.interfolio.com/177622 Suggested deadline: 12/15/2025. @columbiasysbio.bsky.social

Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!) www.science.org/doi/10.1126/... #TBsky

Congrats @thebrysonlab.bsky.social! www.science.org/doi/10.1126/...

New lab preprint! @zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes 🧵 tinyurl.com/ukny4ptz

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.

Ditto. Thanks for this Sarah. www.statnews.com/2025/10/06/g...

We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783

UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu Apply here apply.interfolio.com/174404

UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu Apply here apply.interfolio.com/174404

Congratulations!

Now online! Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...

Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity: