A new frontier for our lab! After many months of development by postdoc @ranaabdelaziz.bsky.social (our resident medicinal chemistry - now also an excellent structural biologist) and the staff at the SickKids Drug Discovery platform, we're conducting our first proof-of-principle inhibitor screen.

In Jan 2006 I started my dream job: running my own research group at The Hospital for Sick Children in my home town, Toronto. Stephanie Bueler started as lab manager on Day 1. Many students, postdocs, papers, and microscopes later we're still going strong - and Stephanie is still putting up with me!

Exciting collab with Paul Palme, Peter Imming, & Adrian Richter! Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f #MedChem #TB #NTM pubs.acs.org/doi/full/10....

New lab preprint! @zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes 🧵 tinyurl.com/ukny4ptz