Richard Lee
@antibioticchem.bsky.social
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New paper from our PANK program in which we incorporate a sulfonamide motif into our modulators. This provides a new H bonding interaction with the gamma-phosphate of ATP increasing potency and improving the pharmacological properties of the leads.
pubs.acs.org/doi/full/10....
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Discovery of Sulfonamide Pantothenate Kinase Activators and Elucidation of the Role of Isoform Selectivity in Cellular Pantothenate Kinase Activation
Coenzyme A (CoA) biosynthesis is controlled by the four isoforms of the rate-limiting enzyme pantothenate kinase (PANK), whose tissue expression and subcellular localization regulate CoA homeostasis. ...
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.5c03452
8 days ago
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#stjuderesearch
enjoying the 2026 faculty retreat at Graceland
about 1 month ago
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reposted by
Richard Lee
Luiz Pedro Carvalho, PhD
3 months ago
Using HCD-MS lipidomics, and synthetic organic chemistry led by Richard Lee
@antibioticchem.bsky.social
and Jiuyu Liu,
@stjuderesearch.bsky.social
we revealed ornithine-, glucuronic acid- and new-to-nature methyl-glucuronic acid-containing lipids substituting phospholipids in the plasma membrane.
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Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology.
www.nature.com/articles/s41...
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Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus - Nature Microbiology
Florfenicol amine hijacks intrinsic resistance in Mycobacterium abscessus, highlighting that antimicrobial resistance mechanisms can be harnessed for antibiotic activation.
https://www.nature.com/articles/s41564-025-02147-9
4 months ago
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reposted by
Richard Lee
4 months ago
New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2
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Kinase atlas uncovers hidden layers of cell signaling regulation
See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.
https://bit.ly/Dabas_Pol2
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reposted by
Richard Lee
4 months ago
Excellent research out of the Lee Lab by @stjudegraduate student Hannah Snoke!
bit.ly/SnokeACSID25
@stjuderesearch.bsky.social
#infectiousdiseases
#DrugDiscovery
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Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...
https://bit.ly/SnokeACSID25
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Our new paper in ACS Infectious Diseases describes the development of a Gram-negative drug discovery platform to optimize drugs that engage their targets within the cytoplasm.
pubs.acs.org/doi/10.1021/...
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Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...
https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00635
5 months ago
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reposted by
Richard Lee
Max Kozlov
11 months ago
Now that the policy is out, we've rolled out an updated version of the story.
bsky.app/profile/maxk...
add a skeleton here at some point
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reposted by
Richard Lee
Derek Lowe
11 months ago
GLP-1 agonists continue to be one of the most high-profile pharmaceutical battlegrounds. A look at recent developments:
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The GLP-1 Saga Continues, And How
https://www.science.org/content/blog-post/glp-1-saga-continues-and-how
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reposted by
Richard Lee
Carolyn Bertozzi
12 months ago
This!!! I hope someone in Washington is listening
www.wsj.com/tech/biotech...
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China’s Biotech Advances Threaten U.S. Dominance, Warns Congressional Report
Congress should invest at least $15 billion to support biotech research over the next five years and take other steps to bolster manufacturing in the U.S., the report said.
https://www.wsj.com/tech/biotech/china-biotech-industry-research-threat-e91dddd6
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reposted by
Richard Lee
Bethany Halford
12 months ago
If you love drug candidates but weren't able to attend the
#FirstTimeDisclosures
symposium at
#ACSSpring2025
, check out my story about the session for
@cenmag.bsky.social
- with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...
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12 drug candidates debut in San Diego
Structures unveiled during first-time disclosures symposium
https://cen.acs.org/acs-news/acs-meeting-news/12-drug-candidates-debut-San/103/web/2025/03
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reposted by
Richard Lee
Jeremy Berg
12 months ago
Updated Dashboard
jeremymberg.github.io/jeremyberg.g...
Added graphs for training grants (T mechanisms: T15, T32, T34, T35) This looks (and is) bleak, but the time for most T mechanisms grants is a bit later. See
bsky.app/profile/jere...
1/3
add a skeleton here at some point
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reposted by
Richard Lee
Derek Lowe
about 1 year ago
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
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A Bifunctional Degrader Reads Out in Phase 3
https://www.science.org/content/blog-post/bifunctional-degrader-reads-out-phase-3
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CBT rising stars in chemical biology is today, many outstanding talks from junior scientists
about 1 year ago
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