Using HCD-MS lipidomics, and synthetic organic chemistry led by Richard Lee @antibioticchem.bsky.social and Jiuyu Liu, @stjuderesearch.bsky.social we revealed ornithine-, glucuronic acid- and new-to-nature methyl-glucuronic acid-containing lipids substituting phospholipids in the plasma membrane.

Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology. www.nature.com/articles/s41...

New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab! bit.ly/Dabas_Pol2

Excellent research out of the Lee Lab by @stjudegraduate student Hannah Snoke! bit.ly/SnokeACSID25 @stjuderesearch.bsky.social #infectiousdiseases #DrugDiscovery

Our new paper in ACS Infectious Diseases describes the development of a Gram-negative drug discovery platform to optimize drugs that engage their targets within the cytoplasm. pubs.acs.org/doi/10.1021/...

Now that the policy is out, we've rolled out an updated version of the story. bsky.app/profile/maxk...

GLP-1 agonists continue to be one of the most high-profile pharmaceutical battlegrounds. A look at recent developments:

This!!! I hope someone in Washington is listening www.wsj.com/tech/biotech...

If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules. cen.acs.org/acs-news/acs...

Updated Dashboard jeremymberg.github.io/jeremyberg.g... Added graphs for training grants (T mechanisms: T15, T32, T34, T35) This looks (and is) bleak, but the time for most T mechanisms grants is a bit later. See bsky.app/profile/jere... 1/3

The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:

CBT rising stars in chemical biology is today, many outstanding talks from junior scientists