Richard Lee
@antibioticchem.bsky.social
π€ 39
π₯ 146
π 11
Our new paper, which presents a novel strategy for targeting antibiotic resistance, is now available in Nature Microbiology.
www.nature.com/articles/s41...
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Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus - Nature Microbiology
Florfenicol amine hijacks intrinsic resistance in Mycobacterium abscessus, highlighting that antimicrobial resistance mechanisms can be harnessed for antibiotic activation.
https://www.nature.com/articles/s41564-025-02147-9
22 days ago
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Richard Lee
28 days ago
New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2
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Kinase atlas uncovers hidden layers of cell signaling regulation
See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.
https://bit.ly/Dabas_Pol2
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Richard Lee
25 days ago
Excellent research out of the Lee Lab by @stjudegraduate student Hannah Snoke!
bit.ly/SnokeACSID25
@stjuderesearch.bsky.social
#infectiousdiseases
#DrugDiscovery
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Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...
https://bit.ly/SnokeACSID25
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Our new paper in ACS Infectious Diseases describes the development of a Gram-negative drug discovery platform to optimize drugs that engage their targets within the cytoplasm.
pubs.acs.org/doi/10.1021/...
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Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...
https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00635
about 1 month ago
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Richard Lee
Max Kozlov
7 months ago
Now that the policy is out, we've rolled out an updated version of the story.
bsky.app/profile/maxk...
add a skeleton here at some point
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Richard Lee
Derek Lowe
7 months ago
GLP-1 agonists continue to be one of the most high-profile pharmaceutical battlegrounds. A look at recent developments:
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The GLP-1 Saga Continues, And How
https://www.science.org/content/blog-post/glp-1-saga-continues-and-how
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Richard Lee
Carolyn Bertozzi
8 months ago
This!!! I hope someone in Washington is listening
www.wsj.com/tech/biotech...
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Chinaβs Biotech Advances Threaten U.S. Dominance, Warns Congressional Report
Congress should invest at least $15 billion to support biotech research over the next five years and take other steps to bolster manufacturing in the U.S., the report said.
https://www.wsj.com/tech/biotech/china-biotech-industry-research-threat-e91dddd6
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Richard Lee
Bethany Halford
8 months ago
If you love drug candidates but weren't able to attend the
#FirstTimeDisclosures
symposium at
#ACSSpring2025
, check out my story about the session for
@cenmag.bsky.social
- with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...
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12 drug candidates debut in San Diego
Structures unveiled during first-time disclosures symposium
https://cen.acs.org/acs-news/acs-meeting-news/12-drug-candidates-debut-San/103/web/2025/03
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Richard Lee
Jeremy Berg
8 months ago
Updated Dashboard
jeremymberg.github.io/jeremyberg.g...
Added graphs for training grants (T mechanisms: T15, T32, T34, T35) This looks (and is) bleak, but the time for most T mechanisms grants is a bit later. See
bsky.app/profile/jere...
1/3
add a skeleton here at some point
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Richard Lee
Derek Lowe
9 months ago
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
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A Bifunctional Degrader Reads Out in Phase 3
https://www.science.org/content/blog-post/bifunctional-degrader-reads-out-phase-3
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CBT rising stars in chemical biology is today, many outstanding talks from junior scientists
11 months ago
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