Such a beautiful and well-rounded discovery, yet another exciting strategy in bacterial immunity. Congrats, Ilya!

📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗: www.biorxiv.org/content/10.1...

Preprint: De-novo design of proteins that inhibit bacterial defenses Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications Congrats Jeremy Garb! tinyurl.com/Syttt 🧵

Congrats @romihadary.bsky.social and @reneechang.bsky.social for dissecting the functional diversity of ALL Sponges! 🧽

An absolute masterpiece by the talented @dinahoch.bsky.social on nucleotide-based immunity

Amazing work identifying novel immune inhibitors based on structural and genomic traits. Congrats Nitzan and everyone!

Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!

This was our latest journal-club paper. Nice use of large-scale AlphaFold modelling & various experiments. Phage proteins’ ability to recognise eukaryotic homologues of their bacterial targets is striking - suggests these proteins evolved to recognise their targets in a fairly mutation-resistnt way.

A fun collaboration with the Whitney, Prehna, and Bosis labs, in which we reveal the role of DUF2169 proteins: assisting PAAR-like domains in forming spike complexes and #T6SS assembly. 🦠 search.app/jDxaUi5yJK9B...

Check out our latest paper using protein structures to uncover immune inhibitors hidden among millions of phage genes! These inhibitors block immune proteins from bacteria, plants and even humans, highlighting how immunity and counter-immunity mechanisms are conserved across the tree of life! 🦠🌿🧍‍♀️

Incredbile work from @soreklab.bsky.social demonstrating how to mine viral genomes to identify immune-modulatory proteins that work across bacteria, plants and animals 😱. Bacteria have been amazing ressources of molecular diversity for biotech and medicine, now viral diversity can be explored too!

Really cool! Remarkable that phage proteins can inhibit human and plant TIR proteins and human cGAS. Conservation of function across such long evolutionary distances identifies new immunomodulators Congrats to @soreklab.bsky.social and Kranzusch labs! What a great collaboration that is 😍 🧪

Viral immune evasion proteins are widespread and block both bacterial and human immune proteins! Go check out Erez’s paper using AlphaFold-multimer to screen for new anti-defense proteins!!🤩🤩

Been waiting a long time to see this in print - phage proteins are capable of inhibiting immune systems across host-domain boundaries 🤯 Big congrats @erezyirmiya.bsky.social et al!!

I'm excited to see the published version of this amazing work. @erezyirmiya et al identified viral proteins that inhibit host immunity using structural predictions of protein-protein interactions. Congrats to you all @soreklab & Kranzusch lab! 🥂

A high-throughput AlphaFold screen reveals phage proteins that bind and inhibit bacterial immune proteins 🤯 Some of them even bind and inhibit eukaryotic immune proteins as well ! Congrats @erezyirmiya.bsky.social @soreklab.bsky.social et al for these beautiful discoveries 👌

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...

I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! www.cell.com/cell/fulltex...

Finally moved to #Bluesky and happy to share our recent work about a new phage anti-defense system, based on NAD reconstitution by new enzymatic reactions. www.nature.com/articles/s41...

Seems like a good time to finally move here ! Taking the opportunity to share our most recent work : www.biorxiv.org/content/10.1...

Happy to see our paper out @ Nat Comm We discovered a bacterial NLR-like pattern recognition receptor that can sense 3 different viral proteins as a signature for infection. This explains its broad defense against different phage families Congrats Nathalie Béchon! www.nature.com/articles/s41...