Romi Hadary
@romihadary.bsky.social
📤 51
📥 39
📝 15
PhD student
@Soreklab.bsky.social
@WeizmannScience Studying phage-bacteria arms race🦠🛡️
reposted by
Romi Hadary
Aude Bernheim
15 days ago
Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed. In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts.
www.biorxiv.org/content/10.6...
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Environment and physiology shape antiphage system expression
Bacteria and archaea encode on average ten antiphage systems. Quorum sensing, cellular, or transcription factors can regulate specific systems (CRISPR-Cas, CBASS). Yet, a systematic assessment of anti...
https://www.biorxiv.org/content/10.64898/2025.12.14.694197v1
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Incredible to learn how far-reaching and diverse Thoeris really is! TIRs play key roles across kingdoms, and this work beautifully highlights their bacterial origins. Congrats
@erezyirmiya.bsky.social
& Azita! 👏🌟
add a skeleton here at some point
26 days ago
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reposted by
Romi Hadary
Aude Bernheim
about 1 month ago
🧬🛡️How are new immune mechanisms created? We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in
@pnas.org
. 👏
@matthieu-haudiquet.bsky.social
, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
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reposted by
Romi Hadary
Owen Tuck
about 2 months ago
Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems:
www.science.org/doi/10.1126/...
Thanks to wonderful coauthors/collaborators/friends, the whole
@doudna-lab.bsky.social
and everyone at
@innovativegenomics.bsky.social
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Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
https://www.science.org/doi/10.1126/science.aea8769
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So proud of
@nitzantal.bsky.social
👏🏻such an inspiring and brilliant scientist!
add a skeleton here at some point
about 2 months ago
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An incredible story revealing a novel defense system that senses DNA shredding during phage infection — beautifully solved by
@ostermanilya.bsky.social
! 🧬✨
add a skeleton here at some point
about 2 months ago
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reposted by
Romi Hadary
Ben Adler
3 months ago
Today in
@nature.com
, we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out
@erinedoherty.bsky.social
and my work from
@doudna-lab.bsky.social
lab here:
www.nature.com/articles/s41...
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A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
https://www.nature.com/articles/s41586-025-09569-9
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reposted by
Romi Hadary
Ben Morehouse
3 months ago
Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today!
www.nature.com/articles/s41...
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The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature
The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.
https://www.nature.com/articles/s41586-025-09557-z
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reposted by
Romi Hadary
François Rousset
4 months ago
Effector-triggered immunity (ETI) indirectly detects pathogen effector activity on the host cell. Kevin Barthes,Tanita Wein and I examine how prokaryotic and eukaryotic viruses deploy similar effectors that activate ETI, underscoring its central role across the tree of life.
tinyurl.com/mr3a3xh2
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Viral effectors trigger innate immunity across the tree of life | Philosophical Transactions of the Royal Society B: Biological Sciences
Viruses are ubiquitous biological entities that exert immense selective pressures on their hosts, driving the evolution of diverse innate immune mechanisms across all domains of life. While innate imm...
https://royalsocietypublishing.org/doi/10.1098/rstb.2024.0077
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reposted by
Romi Hadary
Jeremy Garb
4 months ago
📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗:
www.biorxiv.org/content/10.1...
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Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection
Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...
https://www.biorxiv.org/content/10.1101/2025.09.01.673470
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📢 Preprint out! Together with
@reneechang.bsky.social
@kranzuschlab.bsky.social
and the amazing
@soreklab.bsky.social
, we explored viral sponges to map their diversity and function. Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!
www.biorxiv.org/content/10.1...
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Functional diversity of phage sponge proteins that sequester host immune signals
Multiple bacterial immune systems, including CBASS, Thoeris, and Pycsar, employ signaling molecules that activate the immune response following phage infection. Phages counteract bacterial immune sign...
https://www.biorxiv.org/content/10.1101/2025.08.24.671296v1
4 months ago
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reposted by
Romi Hadary
Renee Chang
4 months ago
Excited to share my PhD work in the
@kranzuschlab.bsky.social
, out now in Molecular Cell
@cp-molcell.bsky.social
We discover Acb4, a new family of viral sponges that sequesters nucleotide immune signals and defines molecular features that enable ligand specificity.
www.cell.com/molecular-ce...
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A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense
Chang et al. discover anti-CBASS 4 (Acb4), a family of viral sponges that inhibits bacterial immunity by sequestering nucleotide immune signals. Acb4 homologs in phages that infect hosts across all ma...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00617-3
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reposted by
Romi Hadary
Kranzusch Lab
4 months ago
The beautiful, ever-expanding universe of viral proteins targeting nucleotide immune signals! Paper by
@reneechang.bsky.social
in
@cp-molcell.bsky.social
on a nucleotide sponge
www.cell.com/molecular-ce...
and preprint by
@doudna-lab.bsky.social
on viral nucleases
www.biorxiv.org/content/10.1...
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A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense
Chang et al. discover anti-CBASS 4 (Acb4), a family of viral sponges that inhibits bacterial immunity by sequestering nucleotide immune signals. Acb4 homologs in phages that infect hosts across all ma...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00617-3
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A beautiful and much-needed review on the role of nucleotides in immunity, congrats Dina!! 💫🧬
add a skeleton here at some point
5 months ago
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Amazing work led by
@nitzantal.bsky.social
👩🏼🔬, identifying new immune inhibitors using structural clues. So excited to see this out! 🧬💫
add a skeleton here at some point
6 months ago
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