Inspired by bacterial and plant immunity, Bohdana set out to identify catalytic activities in animal TIR proteins. She shows that TIR domain of human TLR4 is an enzyme that produces the signaling molecule cyclic ADP-ribose (cADPR). More in her thread and preprint, including on Viridiplantae TIRs.
add a skeleton here at some point
about 2 months ago