Artem Nemudryi
@artemnemudryi.bsky.social
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Assistant Professor at University of Florida College of Medicine
pinned post!
First preprint from the Nemudryi Lab! ๐พ In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
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Bacterial Schlafens mediate anti-phage defense
Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...
https://www.biorxiv.org/content/10.1101/2025.07.24.666596v1
5 months ago
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reposted by
Artem Nemudryi
Osterman Ilya
about 2 months ago
Bacteria can sense when a virus starts shredding their genome โ by detecting methylated mononucleotides. Hereโs the story of how we discovered the Metis defense system ๐
www.biorxiv.org/content/10.1...
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reposted by
Artem Nemudryi
Stephen Tang
3 months ago
Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria.
doi.org/10.1101/2025...
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Only few weeks left to apply - application deadline is October 31st, 2025. โผ๏ธPlease share โ our department is looking for new faculty! The Department of Biochemistry & Molecular Biology @UF is recruiting a tenure-track Assistant Professorโ๏ธ๐ด Link to apply โฌ๏ธ
explore.jobs.ufl.edu/en-us/job/53...
3 months ago
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add a skeleton here at some point
5 months ago
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First preprint from the Nemudryi Lab! ๐พ In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
loading . . .
Bacterial Schlafens mediate anti-phage defense
Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...
https://www.biorxiv.org/content/10.1101/2025.07.24.666596v1
5 months ago
3
50
30
reposted by
Artem Nemudryi
Aude Bernheim
5 months ago
๐ฆ ๐งโโ๏ธFrom bacterial to human immunity. We report in
@science.org
the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt
@enzopoirier.bsky.social
by D. Bonhomme and
@hugovaysset.bsky.social
www.science.org/doi/10.1126/...
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https://www.science.org/doi/10.1126/science.adr8536
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