Sadie Antine
@sadieantine.bsky.social
📤 552
📥 676
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PhD in Virology Harvard Kranzusch Lab Alum
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Sadie Antine
Sam Hobbs
27 days ago
CBASS is a cyclic nucleotide-based antiviral system in bacteria that is related to cGAS-STING signaling in animals. One of the big questions is how CBASS is activated during phage infection? We made some progress on this during my final year in the Kranzusch lab.
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.03.04.709575v1
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Sadie Antine
Inga Songailiene
about 1 month ago
1/5 Happy by a recent biorxiv pre-print about DARNA (PD-T7-3) anti-phage defense system. This system is activated by binding to ssDNA, presented by phage SSB, to cleave tRNA in the anti-codon loop.
www.biorxiv.org/content/10.6...
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Sadie Antine
Ben Morehouse
about 1 month ago
I am incredibly honored to receive this recognition from the Michelson Medical Research Foundation for our work on innate immune signaling.
www.michelsonmedicalresearch.org/news/michels...
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Michelson Medical Research Foundation Awards $750,000 to Rising Immunology Leaders
Michelson Medical Research Foundation (MMRF) is proud to announce the eighth cohort of recipients of its 2026 Michelson Prizes: Next Generation Grants , naming five early-career scientists whos...
https://www.michelsonmedicalresearch.org/news/michelson-medical-research-foundation-awards-750000-to-rising-immunology-leaders
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Sadie Antine
Kranzusch Lab
about 1 month ago
Congratulations to Sonomi Yamaguchi for her paper at
@nature.com
. Sonomi discovered Clover defense and explained how nucleotide signals control each step of viral sensing, immune regulation, and viral restriction – named for her beautiful "four-leaf" structures 🍀
www.nature.com/articles/s41...
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Sadie Antine
Max Fels
about 1 month ago
The giant viruses surprised us at almost every turn of this project, but ultimately led us down a very rewarding path. Happy to share this work is now available online 🧪
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Sadie Antine
Kranzusch Lab
2 months ago
Great new story from Sophie Helaine and Molly Sargen!
www.helainelab.com
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Sadie Antine
Sam Hobbs
2 months ago
Hello world! I am excited to announce my lab is open at the University of Utah in the Department of Biochemistry. We are looking for scientists at all levels interested in studying host-virus interactions in both bacteria and animals. Come join us in beautiful Utah! (photo is 10 steps from lab)
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Sadie Antine
Nature Methods
4 months ago
ExoSloNano: nanogold probe-based labeling of proteins in live cells for cryo-ET and CLEM.
@lindseynyoung.bsky.social
@thevillalab.bsky.social
www.nature.com/articles/s41...
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ExoSloNano: multimodal nanogold labels for identification of macromolecules in live cells and cryo-electron tomograms - Nature Methods
The ExoSloNano system facilitates nanogold probe-based labeling of specific proteins of a wide range of sizes in live cells for cryo-electron tomography and correlative light and electron microscopy s...
https://www.nature.com/articles/s41592-025-02928-4
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Sadie Antine
Erez Yirmiya
4 months ago
I’m happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life.
www.biorxiv.org/content/10.6...
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Systematic discovery of TIR-based immune signaling systems in bacteria
Toll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...
https://www.biorxiv.org/content/10.64898/2025.12.03.692087v1
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Sadie Antine
Ieva Drulyte
4 months ago
🌟 WeINSPIREBio is hosting its first event! On Dec 4, we’re running a webinar: Structures of Success: Career Journeys of Women in Structural Biology If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
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Sadie Antine
Osterman Ilya
5 months ago
Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides. Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
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Sadie Antine
Chlanda lab
5 months ago
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗
rdcu.be/eMmct
We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
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Sadie Antine
Shira Weingarten-Gabbay
5 months ago
🚨 Systems Virology Journal Club – 8th Series! 🚨
#BillSchneider
and I are delighted to announce another round of cutting-edge talks in
#SystemsVirology
! 🦠💡 Join us and an outstanding lineup of speakers, starting Oct 30. Free registration:
shiraweingartengabbay.com/systems-viro...
🔬✨
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Sadie Antine
Kranzusch Lab
6 months ago
Thank you to the Blavatnik Family Foundation and The New York Academy of Sciences for honoring our research uniting human innate immunity and bacterial anti-phage defense at
@danafarber.bsky.social
@harvardmicro.bsky.social
@harvard.edu
bit.ly/4pZUDkF
blavatnikawards.org/news/items/t...
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Sadie Antine
Ben Morehouse
6 months ago
Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today!
www.nature.com/articles/s41...
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The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature
The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.
https://www.nature.com/articles/s41586-025-09557-z
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Sadie Antine
Max Fels
6 months ago
Are viruses capable of regulating protein synthesis in the nuanced way of cellular organisms? Kinda! I’m excited to share some of my postdoc work that leveraged giant DNA viruses to address this question.
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Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life
In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...
https://www.biorxiv.org/content/10.1101/2025.09.30.678621v1
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Sadie Antine
Florian Schur
6 months ago
Huntingtin binds and bundles F-actin! Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery. We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo
#CryoET
#HTT
#actin
doi.org/10.1126/scia...
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Sadie Antine
Kranzusch Lab
6 months ago
You’ve heard of ubiquitination, meet deazaguanylation: Doug Wassarman in our lab discovered phage defense pathways have co-opted Q nucleobase biosynthetic enzymes to catalyze a new form of protein conjugation chemistry
@science.org
www.science.org/doi/10.1126/...
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Sadie Antine
Jason Nomburg
8 months ago
Very happy to share that I will be starting my lab at AITHYRA in October! My lab will use structural bioinformatics and functional genomics to understand the function of viral proteins, with a special emphasis on understanding how viruses subvert innate immunity.
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Sadie Antine
Kranzusch Lab
7 months ago
How can we understand the earliest events in evolution of eukaryotic immunity?
@yao-li.bsky.social
reports incredible molecular fossils of complete bacterial-like operons in eukaryotes that illuminate how animal immunity was first acquired from anti-phage defense
www.biorxiv.org/content/10.1...
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Sadie Antine
8 months ago
Excited to share our new
@natmicrobiol.nature.com
paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩
www.nature.com/articles/s41...
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Molecular organization of the New World arenavirus spike glycoprotein complex - Nature Microbiology
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-depend...
https://www.nature.com/articles/s41564-025-02085-6
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Sadie Antine
Artem Nemudryi
8 months ago
First preprint from the Nemudryi Lab! 🍾 In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.
www.biorxiv.org/content/10.1...
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Bacterial Schlafens mediate anti-phage defense
Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...
https://www.biorxiv.org/content/10.1101/2025.07.24.666596v1
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Sadie Antine
Kranzusch Lab
8 months ago
Many components of human immunity evolved from ancient pathways in bacteria. A beautiful story from
@audeber.bsky.social
@enzopoirier.bsky.social
leverages this evolutionary connection to discover SIRal as a signaling protein in animal TLR-mediated innate immunity.
www.science.org/doi/10.1126/...
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A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
https://www.science.org/doi/10.1126/science.adr8536
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Sadie Antine
Kranzusch Lab
9 months ago
A new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity.
www.biorxiv.org/content/10.1...
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Welcome to the biochemical world of anti-phage nuclease-NTPases!🤩🤩
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9 months ago
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Sadie Antine
Sorek Lab
11 months ago
Out in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage Joint work with the Tamulaitienė and Kranzusch labs
www.nature.com/articles/s41...
Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
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DNA-gated ion channel🤯 Congrats Joel!!
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11 months ago
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Sadie Antine
Melanie Blokesch
11 months ago
Join the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩 Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭! Please visit my lab's webpage for details about the position and how to formally apply.
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Sadie Antine
Amanda Heidt
11 months ago
🧪Exciting news out today in the world of Mendelian genetics (a statement for a niche crowd if ever there was one). Read my piece at
@nature.com
if, like me, you are surprised to hear we hadn't figured this out a long time ago.
www.nature.com/articles/d41...
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Century-old genetics mystery of Mendel’s peas finally solved
Researchers pinpoint the genes responsible for the final three pea traits studied by the famed citizen scientist.
https://www.nature.com/articles/d41586-025-01269-8
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Sadie Antine
Aude Bernheim
12 months ago
It was an honor for my lab and myself to host the meeting on the Immune Systems of Bacteria. Such a high from all the incredible science and sharing with scientists from the whole world the greatness of Paris in the spring. Vive la science, et vive Paris!
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Sadie Antine
Felix Steinruecke
12 months ago
I’m excited to share my first paper in the Farnung lab, in which we report four cryo-EM structures of the human DNA replication machinery engaging with and progressing into a nucleosome.
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Check out Doug’s awesome work!!
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12 months ago
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Sadie Antine
Maya Voichek
about 1 year ago
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
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Sadie Antine
Martin Steinegger 🇺🇦
about 1 year ago
Foldseek-Multimer—now published in
@naturemethods.bsky.social
—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects. 📄
nature.com/articles/s41...
🌐
search.foldseek.com
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Sadie Antine
Alexander Harms
about 1 year ago
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
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Sadie Antine
Angie Rasmussen
about 1 year ago
@charlesgaba.com
is a hero and downloaded CDC’s entire website. A small group of us has come together to preserve this critical resource and make it accessible to the scientific community. More to come. These data are public and they are ours. Deletion disobedience is one way to fight back.
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Sadie Antine
Sorek Lab
about 1 year ago
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
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Sadie Antine
Sean Gibbons 🦠💩
about 1 year ago
To all Americans: call your senators and ask them to oppose the appointment of RFK Jr. as the HHS secretary. He is unfit for that office. Want reasons? Here's what his cousin Caroline Kennedy (daughter of JFK and the former US ambassador to Australia) has to say:
youtu.be/VFw24zVO_3E?...
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Caroline Kennedy attacks ‘predator’ RFK Jr. in scathing letter ahead of confirmation hearing
YouTube video by New York Post
https://youtu.be/VFw24zVO_3E?si=Ta01CfRuiBmDhQ1d
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Viral immune evasion proteins are widespread and block both bacterial and human immune proteins! Go check out Erez’s paper using AlphaFold-multimer to screen for new anti-defense proteins!!🤩🤩
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about 1 year ago
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Sadie Antine
Sorek Lab
about 1 year ago
Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10
www.cell.com/cell/abstrac...
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Structure-guided discovery of viral proteins that inhibit host immunity
Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...
https://www.cell.com/cell/abstract/S0092-8674(24)01478-8
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Sadie Antine
Peter DeWeirdt
about 1 year ago
Excited to share our work using machine learning to predict anti-phage defense systems! 1/n
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Sadie Antine
Aude Bernheim
about 1 year ago
What is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
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Sadie Antine
Eduardo Rocha
about 1 year ago
Here's a project with surprising results: we show the presence of virulent phages across bacterial genome assemblies. Not any phage, and not your typical T1 contaminant, many phages have large genomes and seem to be in a state of persistence/oscillation (?!) between lysogeny and the lytic cycle.
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Sadie Antine
Sorek Lab
over 1 year ago
Discovery of a new family of viral proteins that sequester immune signaling molecules - by Renee Chang, Philip Kranzusch and co
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Sadie Antine
Luuk Loeff
over 1 year ago
What a great way to end the year! ✨ Today in
@cellpress.bsky.social
we report the structure and function of the Shedu anti-phage defense system.
tinyurl.com/4crj6dnx
A long 🧵...
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Sadie Antine
Christian Loyo
over 1 year ago
Excited to share that my graduate work is up on bioRxiv! I found that some SPβ-like phages of B. subtilis have a counter-defense system that inhibits NADase activity from the SpbK anti-phage defense during phage infection and activation of SpbK.
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Sadie Antine
Emily Kibby
over 1 year ago
I’m so excited to share that some of my grad work in the @aaronwhiteley lab is now available on bioRxiv! We used an AlphaFold-multimer screen to uncover how a bacterial NLR-related proteins senses multiple phage-encoded proteins to confer phage protection. Link:
www.biorxiv.org/content/10.1...
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A bacterial NLR-related protein recognizes multiple unrelated phage triggers to sense infection
Immune systems must rapidly sense viral infections to initiate antiviral signaling and protect the host. Bacteria encode >100 distinct viral (phage) defense systems and each has evolved to sense cruci...
https://www.biorxiv.org/content/10.1101/2024.12.17.629029v1
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Sadie Antine
Yunha Hwang
over 1 year ago
Can LLM agents discover novel protein functions? Introducing Gaia Agent 🌎 🤖: an AI biologist capable of reasoning across genomic contexts to predict functions of proteins! Gaia Agent is now integrated with Gaia Search at
gaia.tatta.bio
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Sadie Antine
Nora Pyenson
over 1 year ago
Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵
www.science.org/doi/10.1126/...
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Diverse phage communities are maintained stably on a clonal bacterial host
Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, w...
https://www.science.org/doi/10.1126/science.adk1183
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Sadie Antine
Sorek Lab
over 1 year ago
Registration is now open for the 2025 Symposium on the Immune System of Bacteria, taking place this year in Paris (April 8-10). We have a fantastic lineup of speakers! Register here:
www.sisb2025.conferences-pasteur.org/home
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