Emily Kibby (@emilykibby.bsky.social)

I’m so excited to share that some of my grad work in the @aaronwhiteley lab is now available on bioRxiv! We used an AlphaFold-multimer screen to uncover how a bacterial NLR-related proteins senses multiple phage-encoded proteins to confer phage protection. Link: www.biorxiv.org/content/10.1...

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A bacterial NLR-related protein recognizes multiple unrelated phage triggers to sense infection Immune systems must rapidly sense viral infections to initiate antiviral signaling and protect the host. Bacteria encode >100 distinct viral (phage) defense systems and each has evolved to sense cruci... https://www.biorxiv.org/content/10.1101/2024.12.17.629029v1