Structural Biology Communications (@actacrystf.iucr.org)

Jiye Wang et al.: Cryo-EM structures of a MexB–MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain ##MembraneProteins##DrugEffluxTransporters@osaka_univ_e@UTokyo_News...##IUCrhttps://journals.iucr.org/paper?S2053230X26001202

loading . . .

Cryo-EM structures of a MexB–MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain In this study, cryo-EM structures of the chimeric RND transporter MexBYB, composed of MexB and MexY, are presented, revealing distinct symmetric-like and asymmetric conformations under apo and drug-supplemented conditions. These structures show that the unusually large open clefts observed in MexBYB, similar to those in MexY, represent a unique conformational feature of the MexY porter domain. https://journals.iucr.org/paper?S2053230X26001202