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Towards patient-relevant structures: reviewing body-temperature biological macromolecules and their ligands for pharmaceutical applications Regulation of pharmaceutical lead compounds does not yet involve the need for patient-relevant macromolecular structures determined at 37°C; nevertheless, we highlight the advantages of these to ensure chemical relevance and the identification of changes which may occur under physiological conditions. The PDB and CSD entries for diffraction data measured at ≥37°C, as well as a cryoEM 37°C freeze-trapped structure, are considered and the description includes structures obtained well above 37°C that are relevant to thermophile and hyperthermophile structural biology. https://journals.iucr.org/paper?S2059798325010617