Dominika Borek (@dmborek.bsky.social)

Sub-2 Å cryo-EM structures of transcribing RNA polymerase II reveal critical roles of water molecules in catalysis The roles of water molecules in transcription have long been overlooked due to resolution limitations. Li et al. resolve high-resolution cryo-EM structures of RNA polymerase II and visualize previously undetected water molecules. These waters play essential roles in RNA polymerase II catalysis and in mediating interactions within the transcription machinery. http://dlvr.it/TShqWQ