We’re hiring! Our group at CSHL has openings for postdoctoral fellows in structural biology with a focus on ion channels and receptors in neurotransmission and cancer immunology. Join and pursue unique, cross-disciplinary science to boost your career. jobrxiv.org/job/cold-spr...

2D classes of the 58 kDa sample collected on the 100 keV Tundra TEM with a Falcon C detector at @nusbf.bsky.social @newcastleuni.bsky.social. Still much work to do to optimise the sample & data collection but its cool to see what a 100 keV TEM is capable of. #cryoEM @recon4imd.bsky.social

Made a little prototype extension so these notes can be read/written navigated in ChimeraX too - the idea is to have a kind of "track changes" for building/analyzing/discussing structures that is intrinsically linked to the relevant sites

PARP16 is a Druggable Regulator of Ribosome MARylation and Protein Homeostasis in Ovarian Cancer Cells https://www.biorxiv.org/content/10.64898/2026.04.01.715986v1

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription. www.biorxiv.org/content/10.6... Check out our latest preprint. Great work by @tshamorkina.bsky.social. Thanks to co-authors Danni Snikkers and @hecklab.bsky.social

The newly established NeCEN Utrecht is looking for a #cryoEM scientist! www.uu.nl/en/organisat... Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!

During #RHIC's latest STAR collaboration meeting, members gathered by the STAR detector one final time before it is disassembled and the collider is transformed into the #ElectronIonCollider. RHIC's operations have ended, but its science lives on — with years of data analysis and discoveries ahead.

Chart builder: an interactive tool for user driven data visualization in the electron microscopy data bank pubmed.ncbi.nlm.nih.gov/41868252/ #cryoem

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

Added some of these features (notably copy-paste ligand) to the old coot-trimmings. Also added a menu item to set the proportional editing radius, which changes the "sphere of influence" of refinement to allow easy moving of larger parts of the structure (e.g. domains). github.com/olibclarke/c...

Finally got around to porting my coot-trimmings scripts over to Coot 1... only the hotkeys are working (nothing requiring creating a custom menu or GUI dialog), but I've added a couple of new ones, e.g. copy/pasting ligands. Check it out & let me know what you think! 😊 github.com/olibclarke/c...

‼️Paclitaxel, the best-selling chemotherapy drug in history, may not act exactly as previously thought. It can profoundly alter nuclear morphogenesis during interphase, thereby disrupting critical cellular processes through perturbation of the nuclear domain. doi.org/10.1242/jcs....

We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…)

My new spiritual eukaryote is ciliate in Si helmet swimming towards North pole ⚔️. Definitely an amazing reading from Bolzoni et al. "Magnetoreception in a freshwater ciliate arises from endosymbiosis." 10.1038/s41467-026-70462-8 for #protistsonsky

Distinct subtype of mito !! >> ETC complex III function is necessary for the formation of endoplasmic reticulum and mitochondria contact sites (ERMCSs). Congrats to whole team of Costas and Yatrik !! www.cell.com/molecular-ce...

Brent Pedersen, Mitchell Vollger and I have "posted" our preprint of the manuscript describing bedder, a complement to the functionality of bedtools. The "preprint server" we have chosen is google docs because it was rejected by biorxiv. docs.google.com/document/d/1...

New postdoc position at Cornell! This is a bit of a unique one: It's a teaching postdoc focused on integrating active learning strategies into psychology courses (including one of my own). Should be a lot of fun! Apply here: academicjobsonline.org/ajo/jobs/31738

Mitochondria can indeed be inherited from the father! 🍀 In this new study, we uncovered the molecular mechanisms underlying mitochondrial inheritance in Nicotiana tabacum. @natplants.nature.com doi.org/10.1038/s414...

We talk a lot about mitochondrial stress, but how about how do they keep themselves balanced? Good thing our speaker @nieminm.bsky.social knows everything about that, and will tell all on the next MITOtalk. Usual time and place. See you there?

Excited to share our preprint exploring the structural, biochemical and in vivo properties of DRT7/UG10 reverse transcriptases which produce dsDNA using their primase and polymerase activities and provide broad-spectrum antiphage defense! www.biorxiv.org/content/10.6...

#StreetArt by Explicit Citizens. Lisbon, Portugal, 2024. #Caturday

This is a fantastic example of how to begin as a newcomer to #cryoEM. Being proactive in getting advice from experienced scientists and going to any of the great workshops would likely lower the incidences of erroneous structures in the EMDB and PDB (There’s not a lot but there are a few).

Happy birthday to Charles Darwin, patron saint of tired scientists, grumpy fieldworkers, and hating your own manuscript.

Some cool E3 ligase structures here with calmodulin-mediated oligomerisation. Also interesting collection/processing to deal with preferred orientation. www.biorxiv.org/content/10.6...

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...

Co-chairing IUCr 2026 MS-012 “Next-generation validation metrics for macromolecular structures” with Deborah Harrus (@deborah83.bsky.social)! Focus: new validation concepts/methods/best practices across all methods. Submit abstracts by Feb 15; early-bird reg by Mar 31. www.iucr2026.org

New on the CryoET Data Portal: ~27,000 tomograms of affinity-captured lysosomes from HEK293T cells across 4 physiological states. Includes raw data, AreTomo3 reconstructions & Membrain-Seg annotations. Openly available for reuse! cryoetdataportal.czscience.com/depositions/...

We have two funded postdoctoral positions available. Topics encompass: -Next gen light-sheet fluorescence microscopy instrumentation -Structured illumination microscopy and other approaches to extend the resolution limit. -Nonlinear microscopy combined with adaptive optics / phase conjugation

🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...

#teamtomo gets another quantitative cell biology tool! We extend our Surface Morphometrics pipeline to measure membrane thickness. Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).

Larissa Lopes Cavalcante et al.: Crystal structure of di­acet­y­lene unveiled by X-ray and neutron diffraction, Raman spectroscopy and periodic DFT ##IntermolecularInteractions##MolecularCrystals... ##IUCrhttps://journals.iucr.org/paper?S2052252525010486

The atomic ensemble time scale at the NIST Boulder campus has failed.

While stories of singular DNA changes that drove evolution of human brain/behaviour remain seductive, advances across multiple fields of biology cast doubt on such simplistic narratives of our origins. A new paper from my lab shows how biobanks may speak to this fundamental question.🧪 Explainer🧵👇1/n