Metascience 2025 recordings are now available! #Metascience25 gathered researchers, funders, policymakers & more to explore how the research process can improve. The program included preconference symposia & plenary sessions on topics from policy change to AI in research. 🎥 cassyni.com/s/metasc...

📢 Abstract submission deadline reminder for 'Cell biology of the nucleus'! Before packing your bags and leaving for your summer vacation, there is one important task left to do: submit your abstract for #EESNucleus ✍️ Deadline is 26 August: https://s.embl.org/ees25-07-bl

So excited to be in Heidelberg for www.embl.org/about/info/c... ! This is going to be an awesome meeting, been looking forward to it for months! #EESTCBio

Unlawful grant terminations are harming young scientists and threatening innovation. ASCB joins leaders calling for immediate funding restoration. www.ascb.org/society-news...

🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

I’ll be there! Can’t wait!

Losing MOSAIC is such a senseless gut punch to so many deserving people like my lab mate @aralbright.bsky.social and science as a whole. www.npr.org/sections/sho...

For #FluorescenceFriday, a GFP reporter shows nuclei (fire) nestled between lots of lipid droplets in this set of adipocytes 🔬 #Microscopy #CellBiology

This is incredibly cool: if you search for a condition that’s affected your family, the site returns stats on how much NIH has done for that disease, *and* a contact form for reaching out to tell your Members of Congress why you want to see them defend NIH. Pass it on!

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

A dream come true: the first expansion microscopy images of C. flexa 🤩 Generated by Mylan & Uzuki who learned from the best (@hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social). We will learn so much from these!

Come to the Annual Fletcher Lab Artshow on Friday May 9th, 2025! We host this event yearly as an opportunity for folks to display their artwork, come together with wine and cheese, and admire artwork!

Many thanks to my co-author Brooke Weingard, my advisors Steve Goodman & @wallaceucsf.bsky.social , my Marshall lab mates and many others who have been supportive of this sort of oddball project. Now more than ever, I'm humbled by the absolute privilege of doing science! thanks for reading! 11/11

I'm excited for this chance to highlight the power of rigorous evidence synthesis for fundamental cell biology, something I hope to see more of and help develop in the future! If you're interested in the intersection of evidence/knowledge synthesis & fundamental bio please connect with me! 10/11

Stay tuned for part two of this story which will dive into the linguistic and conceptual basis of "cell anatomy" throughout the corpus. We plan on keeping this corpus up to date & expanding its scope as a collaborative interactive resource (we call it a "living corpus" as a running joke ) 9/11

We believe that the acceleration of whole-cell imaging tech & data in recent years represents the early stages of an emerging field. Hopefully this work will serve as a useful tool and catalyst for community discourse to standardize technical & conceptual norms. 8/11

But there are biases in the dataset! Namely small sample sizes, small cell types, non-mammalian cell types. This is a reflection of how technically challenging and costly whole-cell data is, even further highlighting the value of pooling datasets for research synthesis work. 7/11

This lights the way for lots of followup work e.g., which organelle-organelle relationships are more robust vs variable across perturbations? what geometric rules govern whole-cell patterns in eukaryotes? 6/11

Our corpus includes 89 studies published bw 2004-2024 screened from >11000 Pubmed results: nearly 1700 individual cells, 118 distinct datasets in 80 cell types using 13 volumetric imaging modalities, 71 comparative conditions, and at least 12 types of quantitative analyses. 5/11

To be included, studies had to show images and/or report measurements taken from complete single-cell reconstructions containing at least two clearly marked organelles in a eukaryotic system. 4/11

Our scoping review methodology involves a robust search strategy for PubMed, strict inclusion criteria, and multiple rounds of screening and subsequent data extraction performed by multiple researchers in parallel, all fully reported and reproducible. 3/11

We devised a synthesis approach to comprehensively curate whole-cell imaging data across the literature to enable comparative analysis of anatomical patterns across cell types & contexts. 2/11

New(ish) preprint! 📰What whole-cell patterns emerge from the arrangement, morphologies, and interactions of organelles in the 3D space of the cell? What would we see if we could gather ALL the whole-cell reconstruction data that's out there in one place? www.biorxiv.org/content/10.1... 🧵 1/11

Trump's team backing down in front of Harvard should embolden EVERYONE to stand up to them. Do not comply in advance. Instead say "Fuck you, make me."

How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n) 📖 www.biorxiv.org/content/10.1...

Bioimaging and bioimage analysis friends, some help if you have 2-3 mins; for a paper, we're trying to estimate the number of biologists trained in open source software or tools in the last ~5 years. (1/2) #bioimaging #microscopy #bioimageanalysis

I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful). Let’s call it a Orwellial.

Upon learning that yesterday would be my last day as a program officer at the National Science Foundation, I shared this parting message with my colleagues. The next few months will be frenetic and stressful for them. Here are some things that you can do to help them with the mission ahead. (1)

Not certain what is happening with PubMed - see banner headline below. I hope 🤞 it's not going down - just a lot of people searching and downloading records important to their field. If PubMed does goes down use @europepmc.org it includes current PubMed abstracts plus a lot lot more. #PubMed

I just contacted my representatives about the nomination of RFK, Jr and the recent executive orders. Here is what I wrote in my email or said to the staffer on the phone: Hello- I am writing/calling on several topics:

Part of a letter I sent today to my Congressional Representative and Senators.

We already have an amazing speaker line up and it will be even better if you join! Only few days left to submit an abstract meetings.embo.org/event/25-cel...

I was a #refugee. English was my 2nd language. I am an #NIH funded #physician-researcher who believes in science & human compassion. I am a #childlesscatlady. I am well aware that I am everything this administration hates, and I have no intention of going quietly into the night. #medsky

My dad was tortured by the Gestapo for 4 days and thrown in a concentration camp for being in the Norwegian Resistance. Growing up, he would tell me things he learned in the Resistance. I thought, I'm never going to need this stuff. Here's some of those things #Thread

I was today years old when I learned our Life Sciences societies are working together www.coalitionforlifesciences.org/take-action/

🚨Next week, Wed 29/01 | 16:00 UK - Online Seminar🚨 "Patterning, waves and synchronization in cilia arrays" by Dr. Guillermina Rochelle Ramirez-San-Juan. Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr... #cilia #livingmatter #biophysics

Super cool, can’t wait to read in depth but we really need more of this type of discourse!!

A case for broadening our view of mechanism in developmental biology Read this Perspective Article from B. Duygu Özpolat @biyolokum.bsky.social , Swathi Arur @swathiarur.bsky.social and Mansi Srivastava: https://journals.biologists.com/dev/article/152/2/dev204605/365016/

Super interesting thread

Did your child lose their book collection in the Los Angeles fires? Are you a teacher at a school that lost its library or your classroom library? Whether you need one book or a whole library, we can replace your books. 📚 Everyone else, please boost this post so we can connect with those in need. 🙏

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

Caltech has set up a disaster relief fund for Caltech and Jet Propulsion Lab community members affected by the fires. Many lived in Altadena, which has been very heavily damaged. Please consider giving. giving.caltech.edu/areas-to-sup...

We argue against an impoverished understanding of exploration as serendipitous discoveries in existing datasets. We observe that exploration is often guided by theoretical assumptions. We further argue that good exploration exists and it needs to be thorough and systematic, rather than haphazard.

#Organelles closely interacting within a #cell videoed under a microscope Love how the mitochondria (orange) crawl on top, & are almost embedded within the nucleus (cyan) (rendered with ChimeraX @www.cgl.ucsf.edu) @focalplane.bsky.social @dgz.bsky.social @cellcommlab.bsky.social #Scisky #scicomm

Expert's Dilemma: the more specialized you become, the less open you are to creative solutions from other fields. But the more you explore other fields, the more you risk losing credibility in your home field. Interdisciplinary work is still not really embraced by academia.

The Philosophy of Data with @sabinaleonelli.bsky.social, @vlastasikimic.bsky.social, and Rhaul Sam #PhilSci #PhilSky