maybe it isn’t a coveted Nobel parking spot, but at least I get to feel special when I go to the dentist who I happen to share a last name with 🦷🪥

Our work on Naegleria Myosin 2 is out! Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea. Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling. Read more: www.cell.com/current-biol...

This kind of inconsistency is often used to lift up a few women without helping all, maintaining misogyny. How many other women, and non-white people, could have had a similar effect given the chance or opportunity? We will never know.

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

when you and your friend @dnamystrom.bsky.social both win awards from @ascbiology.bsky.social MBoC you celebrate with hot pot and nails that match your shirt 😍💅

Sharing stories matters. If you’ve faced grant terminations, funding delays, loss of research jobs, etc., your voice is needed. Help show the real impact of NIH funding interference - tell your story so we don’t lose innovation, cures, and hope for the future. www.27unihted.org/biohealthbeats

I am so grateful to have the opportunity to work with Vincent and @wallaceucsf.bsky.social in the first place, but I am so happy that Vincent and I were awarded Paper of the Year at MBoC 🤩 www.ascb.org/society-news...

Here is a word cloud of the words that were missing from the noncompetitive renewal awards but had been present in the parent award. 3/4

What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells? www.biorxiv.org/content/10.1... Video by Vittorio Boscaro. 1/n

Listed are some of the many NIH research training programs that were terminated! Together, these programs supported thousands of trainees, whose careers are now in limbo. Such a great loss for discovery and innovation. We must protect our next generation of scientists! #HandsOffNIH #ProtectScience

As one can imagine, I have some thoughts. Here’s a thread no one asked for: 1. SCIENCE IN THE US IS POLITICAL. No matter how much you want to ignore that fact, it is supported by taxpayer dollars and is therefore, political by nature. 2. BUT it has had bipartisan support for decades, which…

I have certainly lost a lot of hope in this process, but it is nice to see some people are still advocating for us. Thanks @jeremymberg.bsky.social

I am one of these faces. I certainly do feel like my life has been turned upside down multiple times this year, but I will always love my #NIHMOSAIC family and I am so glad we have people like @jeremymberg.bsky.social fighting for us ❤️

Throughout this whole saga, I’ve felt the collective agony of being in constant contact with other MOSAIC scholars facing the same shitty fate. I don’t want to downplay the deep solidarity/support, but what I feel most acutely is the wave of grief crashing over hundreds of early-career scientists.

Really important article in the NY Times today about cuts to NIH diversity grants, featuring a profile of Ashley Albright @aralbright.bsky.social who is an amazing and super inspiring cell biology postdoc whose K99 was prematurely terminated.

Still waiting... www.science.org/content/arti...

Read preprints. Cite preprints. Email people and tell them you loved their preprint. Email people you hated their preprint. Embrace preprints, preprints are good.

I’ll say that yesterday wasn’t necessarily the happiest birthday I’ve ever had, but I love the solidarity from my friends and @uaw4811.bsky.social Thank you UAW and thank you to the person that captured this photo of my sign at the rally ❤️

To say I’m devastated to lose what I’ve worked SO hard for is an understatement, but I am trying to remind myself of how grateful I am for the community I got from it. ❤️ you ASCB and friends

I have heard the final goal for overall cuts (external and internal) is higher than this. What are we doing to prepare? It’s clear that most places are not about fighting back, so I hope you have a plan to protect your people and the research that you’ve indicated is critical your mission.

I'm ready to stand up for science and make jokes at @mbeisen.bsky.social's expense at the same time with these buttons 😈

“You can’t spell felon without Elon” - @aralbright.bsky.social

If anyone tells you to "just focus on your science" right now, tell them to fuck off. Our careers and livelihoods are at risk. This is not a drill.

The expiration date for the MOSAIC program was updated to today 😞: www.grants.gov/search-resul...

The only problem is, you can't just order Stentor pyriformis from a supply center

Check out Wallace’s blue-torial on our work describing the cell biology and genome of Stentor pyriformis, and the Chlorella endosymbiont that affects Stentor behavior 😱 #protistsonsky #stentor

can confirm it will be very a cool talk 🧬😀 #cellbio2024

Think mitochondria are networks of cylindrical tubes? not always! Check out poster by @gavsturm.bsky.social "Mitochondrial Pearling: an emerging class of organelle dynamics explained by a biophysical pearling instability" tomorrow Sunday Dec 15 11:45-12:45 B145

How does patterning get set up WITHIN a single cell? if you are curious and are at ASCB, check @aralbright.bsky.social 's poster "Half-Cell RNA Sequencing Reveals that the Microtubule Cytoskeleton Dictates RNA Localization Patterns in Stentor coeruleus" Sunday Dec 15 1:30-3:00 poster B290

Happening today!! Toward in vitro organelle interaction systems, 9:30-11am, 33B. So excited to be here and to have the opportunity to keep this discussion rolling! #cellbio2024 @ascbiology.bsky.social #CCC

learning about biology at the San Diego zoo before #cellbio2024

Because my goal is not to get tenure, but to do great science and not be a crap person, no one has power over me. I also am well aware of my own power: pre-tenure folks have connections too. All this to say, let’s stop being afraid and stand up to bullies.

UCSF, put some respect on my (all postdocs tbh...) name! Not blaming the person that sent this at all because it's probably in the system this way, but in an email to both me and @wallaceucsf.bsky.social "Dear Dr. Marshall, Ashley," 😐 small potatoes in the grand scheme of things, but still.

Find me at #cellbio2024: Part 1 I'm so excited to co-run our subgroup Toward Building in vitro organelle interactions w/ GW Gant Luxton and Hanaa Hariri !! 😀 Sat 12/14, 9:30-11am, Rm 33B. A little backstory to this unusual topic: 1/

missing a few people, but @wallaceucsf.bsky.social lab is best lab 🧬🔬

If you like Wallace's blue-torial (what are we calling the tweetorial equivalent over here btw) and are going to ASCB, look out for my talk Tues. Dec 17th on how the microtubule cytoskeleton dictates RNA regionalization in Stentor! #cellbio2024 #stentor #protist #NIHMOSAIC

Oooo yeah stentors need more love!!!!

#RNA enthusiasts, got a question for you.. How could one experimentally differentiate b/w a net increase in RNA synthesis vs. an issue with RNA export (like RNA getting stuck excessively in the nucleus)? Are there tips/tricks in single nucleus seq or RNA-FISH etc to be able to delineate this?

How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography www.biorxiv.org/content/10.1...

Check out our meeting review on unconventional and emerging organisms in this issue of Development! journals.biologists.com/dev/article/...

I started working on a poster 30 minutes before I needed to submit to the print shop, but I got it done... am I ready to be a PI now? Find me at ASCB! :)

how does one just not obsessively check era commons even though they know the NIH won’t post scores on a weekend? 😩

It’s out! Via hydrogen deuterium exchange, biochemistry, and cryo-EM, we (Peter Walter lab, Susan Marqusee lab et al) discovered the allosteric mechanism controlling activity of the core Integrated Stress Response (ISR) regulator eIF2B. 1/10 www.nature.com/articles/s41...

black glasses, CCC shirt, khakis, mtn dew (SO gross), joy for science... Where is Wallace? @wallaceucsf.bsky.social

I like sending emails to cool preprint authors, I call it fanmail. Better yet, I like when people email me because they think my work is cool 🥲

barney 🥰

how is it that professors continually get away with misappropriating thousands of dollars and... creating sexually hostile environments... yet trainees get shit when we just want our measly hundred bucks back for covering a group meal? iykyk my UCSF friends, if you don't... holler at me.

watercolor shark!