Excited to share my latest work in the @oliveiramann.bsky.social lab, where we examined STING dependent and independent nucleotide signalling pathways in human cells with a library of 78 nucleotides by RNA-seq and imaging analysis

Finding a foothold to fight: New insights into the viral RNA sensing and activation mechanism of OAS2

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504 @oliveiramann.bsky.social 🎥ProLehre

Happy to share the first preprint from my lab by @indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity! Check out Indra’s thread for a summary:

Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1

I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...