New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵 Collaboration with the Giessen and Pi labs Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav! www.biorxiv.org/content/10.1...

Ever wondered how to position organelles in bacteria? Wonder no more! Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab. The avenues this opens in the synthetic biology space are enormous! Movie: Carboxysomes positioned in E. coli! Preprint: shorturl.at/D6xVg

If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...

HPV is the most common STI. Revisiting the infection pathways, we discover that, contrary to the accepted model of trafficking, HPV stays intact and infectious in host cell lysosomes 🤯. Among other discoveries, we show that the intact virus is a cargo of COPI-coated pits!

Happy to have contributed to this amazing story by Hari!

Our new preprint: how photoprotection is spatially coordinated with energy metabolism. Photosystem I is major source of radicals. We report EM structure of PSI in complex with superoxide dismutase SOD: direct link between energy conversion & oxidative stress defence www.biorxiv.org/content/10.1...

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation. Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation. cryotud.github.io/locscale/

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

Toggle-Untoggle: A cell segmentation tool with an interactive user verification interface. https://www.biorxiv.org/content/10.1101/2025.05.21.655178v1

Happy to have contributed to this amazing story from @caroleparentlab.bsky.social at the @umlifesciences.bsky.social www.nature.com/articles/s41... Congrats to all involved.

Problem cryo-ET structure alert. A recent paper by Lange et al. in @natcellbio.nature.com (tinyurl.com/38s6a4dn) reported an unusual-looking model of the prohibitin complex in situ. We asked: how was this structure generated? Our reanalysis offers an explanation: tinyurl.com/mszdtwxx 🧵

Together with Herman Fung, we are looking for a #machinelearning #AI expert to join our groups. Details below.

*Deadline extended* Applications for this year's #CryoEM Data Processing Workshop are due March 27! Don't miss this chance to learn about various approaches to deal with conformational/compositional heterogeneity. myumi.ch/lsi-cryo-2025 @jbquerido.bsky.social @shyamalm.bsky.social

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

“Thermo Fisher Scientific is hosting a webinar on securing capital equipment funding for new EM technology” - sophisticated public money extraction machine go brr

Happy to share this work from my group on the endolysosomal/PM resident 2 pore potassium channel with roles in #inflammation We determine the structure and show that it is pH independent, voltage-gated using high-throughout whole cell electrophysiology assay. www.biorxiv.org/content/10.1...