Have a read of our new article now out in Neuron! www.sciencedirect.com/science/arti... We used Cryo EM, electrophysiology and MD simulations to determine the structure of S-(+)-Ketamine at its most pharmacologically important NMDA receptor subtype, and show the basis for DQP subtype selectivity!

Very nice to see the work of Matt Warren and Isak Valsson just out with Charlotte Deane, Aniket Magarkar and @garrettmm.bsky.social where we show how augementation can dramatically improve ML affinity predictions to close to FEP accuracy. rdcu.be/d88Wm

I’ve seen some posts recently, about the value of basic research, in light of funding cuts and demands that research have immediate economic justification. Let me collect some info here, in a thread, about why it’s a bad idea to attach those sorts of demands to funding. 🧵 🧪 ⚛️