Let's make 2026 a great year!!! ✊️💚

Happy holidays everybody!! 🌲

#EMBOComp3D has officially begun! 🥳 What are you looking forward to in the next few days?

On the train to Heidelberg for the @EMBO workshop #computational_structural_biology, excited to hear about the latest developments in the field and share some recent work!

Utrecht 2025

Has anybody noticed how #Boltzgen does not output pLDDT in the ADP column of the output .cif files in the way Boltz1/2, AF2/3, Chai1 etc do? Especially weird since it uses Boltz2 to generate these models, has it been taken out to speed up calculations? Preprint doesn't mention it.

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

This year, for Postdoc Appreciation Week, could we please STOP referring to them as TRAINEES! They are exceptionally qualified professionals, highly experienced researchers, mentors, educators, world-leading experts in their field, grownups with responsibilities, not interns!

As it's the season, 3 options for those wishing to cook pumpkin: 1. Suffer when trying to peel a raw pumpkin 2. Boil the pumpkin with skin on (skin comes of easily), suffer when trying to clean the pot later 3. Suffer when eating the awful pre-cut pumpkin (fridge or frozen) 🥴

It seems trendy lately to have visualizations of 3D proteins structures generated by AI. These show very ugly artifacts, akin to AI pictures of humans with the wrong number of fingers. It is really not hard to make a visualization of a random protein structure using free software! #AI-slop

We are experiencing a period of remarkable technological advancement ( #CryoEM, #CRISPR, #alphafold, protein design) unparalleled in the past decade. Keeping pace is challenging, continuously adapting to technological developments that may become obsolete by the time you've mastered them. 🤕

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org. pubs.acs.org/doi/10.1021/... @xdh.bsky.social @hangryhobbit.bsky.social

In Science, researchers detail a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. #WorldBrainDay scim.ag/3FvpAKy

Preprint alert! With #PFAS contamination becoming an environmental crisis, we dared to engineer natural defluorinases towards degradation of (un)natural organofluorides. How? Check out our robust growth-based selection platform here: www.biorxiv.org/content/10.1... thanks to @mayerlab.bsky.social !

Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen: www.knaw.nl/nieuws/breng...

Wow, just wow! www.nature.com/articles/s41... I was working on that at the MRC-LMB from 2017-2019...

Cool visualization of MAG cis dimerisation and trans ganglioside binding at the axon-myelin interface by Krzyszlof Anklewicz, a bachelor student @utrechtuniversity.bsky.social. This structure was the main discovery of my PhD! Find the open access paper here: www.nature.com/articles/nco... #glycotime

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...

Four LAPD officers on horseback surround a man laying on the ground, trample him, and beat him with their polycarbonate "saber" batons.

This is his only biography now

🇨🇦🚨Job Alert🚨🇨🇦 Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget) U Toronto, Dept of Biochem/LabMedPath *Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?) Are you an established PI ready to move to 🇨🇦? research.utoronto.ca/funding-oppo...

Next week will be the FEBS Advanced Lecture Course 'Emerging insights from structural biology into molecular mechanisms of diseases', where I will present new structural biology and protein engineering results at the 'Academia meets industry' session. Hope to see you there!

Liposome Encapsulation Enables Near-Native Cryo-EM Structural Determination by Shielding Macromolecules from Non-Physiological Interfaces www.biorxiv.org/content/10.1101/2025.05.06.652550v1 #cryoem

Nice work on coronavirus HKU1-A spike opening by Min Jin et al.: www.nature.com/articles/s41... With a longer glycan and higher resolution structures, they nicely confirm our conclusions (www.nature.com/articles/s41...) and add new insights.

Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach. More details: www.nature.com/naturecareer... Apply by 04 MAY #PostdocJobs #ScienceJobs

Air pollution has dropped significantly in #Paris in the last 15 years as a result of a deliberate strategy. Mayor @annehidalgo.bsky.social’s leadership has traded car space for green space, safe bike space, kid space.. and traded pollution for people. Good trade.

Wat een serpent... Faber geeft geen goedkeuring voor lintjes COA-medewerkers - nos.nl/l/2561674

MAR added DT DT: Covfefe MAR removed DT from the group

👊🏴‍☠️🔥 🤪

Ketamine is one helluva drug

French researcher, going to a conference in Houston, was forbidden entry to US; his work and personal electronics were both confiscated. Why? Because a “random search” of his cell phone revealed a negative personal opinion on Trump and the Trump administration. www.lemonde.fr/internationa...

Excited to share our preprint about proteins that we found in preparations of glycoRNAs now available on bioRxiv! #glycotime (1/9) www.biorxiv.org/content/10.1...

Deafening silence everywhere. Noone has learned from the history of former dictatorships. Fear is a contagious disease.

Dear American friends. Have you not noticed you are sliding into totalitarianism at a very rapid pace? Where are the mass protests, the voices of opposition (democrats, celebrities)? Once the dictatorship is firmly established it will ve very difficult to return to democracy...

Mike spotted this before the rest of us. 🫡 Publications from 2025 are shared more on Bluesky than on X/Twitter.

@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/... #RNAsky #RNAbiology #Cryo-EM

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

‘Travel agencies charge far more than it would cost an academic to arrange their own travel and accommodations - sometimes staggeringly more.’

Excited to share our latest work, led by the incredible @automnenine.bsky.social (now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome. www.science.org/doi/10.1126/...

Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch

Cool membrane protein structure enabled by a Nanobody: www.nature.com/articles/s41...

I am very happy to announce that we solved the in-virus #cryoEM structure of the #HIV matrix protein. The structure helped us to resolve a long mystery in HIV biology. A🧵1/5 Read more in Nature: www.nature.com/articles/s41... 🧪

we recently found some really neat RNA-guided DNA-cutting systems in phages. Despite remarkable similarities to CRISPR systems, including encoding guide RNAs in arrays, they appear entirely evolutionarily distinct (but definitely related to snoRNAs 🤓) We decided to call them TIGR-Tas systems 🐯

For all of you who cannot access pubmed, here is a good alternative: europepmc.org

One of Hitler's favorite tactics was to invite leaders he wanted to dominate to personally meet him and then ambush them with insults and wild demands such as with the Austrian Chancellor before forcing the Anschluss. Schuschnigg's own words:

Hey @alphafold.bsky.social, is there an argument to make AF2 output in pdb format instead of the standard json?

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production elifesciences.org/articles/102... Doesn't this suggest that not Aβ generation, but loss of function of γ-secretase is the problem in familial Alzheimer's disease?