We are implementing a similar policy at @arxiv.bsky.social. If there is incontrovertible evidence of LLM slop in a paper, this means the authors did not take the time to read the LLM output and we can't trust anything else in the paper. Penalty is 1 year ban from arXiv followed by...

A wise man once told me you should celebrate the small wins as well as the big. First pcr of the new lab successful!! 😁😁 #still_got_it

The newly established NeCEN Utrecht is looking for a #cryoEM scientist! www.uu.nl/en/organisat... Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!

My first time at the Dutch society for thrombosis and hemostasis society (NVTH) symposium, looking forward to hear lots of interesting science and get to know the community!

Now that we are in a full-blown oil crisis, can we finally just ban these smelly cancer-causing fumes exhausting combustion engine scooters? Swap it for an electric bike (similar price) or scooter, or even better, an old-fashioned muscle-powered bicycle (cheapest, best for health and environment)!

Very cool paper on folding rates for small single protein domains: journals.aps.org/prl/abstract... Now that we know these domains fold very fast (0.7-4 microseconds), it should be possible to simulate this by MD and compare, right? This might be helpful in improving MD force field accuracy.

Is there PFAS in baking paper a.k.a. grease-proof? It isn't food so no ingredients are listed. A.I. says there might be. Wouldn't that be pretty insane as you are literally cooking your food on it? Same question for 'wax' programs in car wash stations, shouldn't this be banned??

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

With sadness we share the passing of em. prof. dr. Hans Vliegenthart, founder of the Bijvoet Centre for Biomolecular Research at Utrecht University. His scientific legacy will continue to inspire. In memoriam: www.uu.nl/en/news/in-m...

Happy lunar new year to all those who celebrate!! 🐴

'New research mostly starts with the arrival of junior group leaders'. Amen Thijn Brummelkamp!! 🙏

It feels official now... www.sanquin.nl/en/researche...

Congratulations to former LMB postdoc @mfpronker.bsky.social, who is launching his own independent research group at Sanquin Research where he'll use protein engineering and structural biology techniques to study important blood protein complexes. Best of luck to you Matti! #LMBAlumni

Would recommend, Elena does fantastic science!!

I am excited to share that I will be starting my lab @Sanquin-forlife Research in Amsterdam this month! Looking forward to do structural biology and use protein engineering to tackle important questions related to 🩸blood🩸 protein complexes in health and disease. 🧬🧫🔬🧪👨‍🔬 #cryoEM #xtallography

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...

Just got this in the mail from @addgene.bsky.social, recognizing that 100+ labs have now ordered our anti-FLAG-M2 plasmids via their service. @mfpronker.bsky.social www.addgene.org/Joost_Snijder/ pubs.acs.org/doi/full/10....

Let's make 2026 a great year!!! ✊️💚

Happy holidays everybody!! 🌲

#EMBOComp3D has officially begun! 🥳 What are you looking forward to in the next few days?

On the train to Heidelberg for the @EMBO workshop #computational_structural_biology, excited to hear about the latest developments in the field and share some recent work!

Utrecht 2025

Has anybody noticed how #Boltzgen does not output pLDDT in the ADP column of the output .cif files in the way Boltz1/2, AF2/3, Chai1 etc do? Especially weird since it uses Boltz2 to generate these models, has it been taken out to speed up calculations? Preprint doesn't mention it.

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

This year, for Postdoc Appreciation Week, could we please STOP referring to them as TRAINEES! They are exceptionally qualified professionals, highly experienced researchers, mentors, educators, world-leading experts in their field, grownups with responsibilities, not interns!

As it's the season, 3 options for those wishing to cook pumpkin: 1. Suffer when trying to peel a raw pumpkin 2. Boil the pumpkin with skin on (skin comes of easily), suffer when trying to clean the pot later 3. Suffer when eating the awful pre-cut pumpkin (fridge or frozen) 🥴

It seems trendy lately to have visualizations of 3D proteins structures generated by AI. These show very ugly artifacts, akin to AI pictures of humans with the wrong number of fingers. It is really not hard to make a visualization of a random protein structure using free software! #AI-slop

We are experiencing a period of remarkable technological advancement ( #CryoEM, #CRISPR, #alphafold, protein design) unparalleled in the past decade. Keeping pace is challenging, continuously adapting to technological developments that may become obsolete by the time you've mastered them. 🤕

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org. pubs.acs.org/doi/10.1021/... @xdh.bsky.social @hangryhobbit.bsky.social

In Science, researchers detail a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. #WorldBrainDay scim.ag/3FvpAKy

Preprint alert! With #PFAS contamination becoming an environmental crisis, we dared to engineer natural defluorinases towards degradation of (un)natural organofluorides. How? Check out our robust growth-based selection platform here: www.biorxiv.org/content/10.1... thanks to @mayerlab.bsky.social !

Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen: www.knaw.nl/nieuws/breng...

Wow, just wow! www.nature.com/articles/s41... I was working on that at the MRC-LMB from 2017-2019...

Cool visualization of MAG cis dimerisation and trans ganglioside binding at the axon-myelin interface by Krzyszlof Anklewicz, a bachelor student @utrechtuniversity.bsky.social. This structure was the main discovery of my PhD! Find the open access paper here: www.nature.com/articles/nco... #glycotime

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...

Four LAPD officers on horseback surround a man laying on the ground, trample him, and beat him with their polycarbonate "saber" batons.

This is his only biography now

🇨🇦🚨Job Alert🚨🇨🇦 Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget) U Toronto, Dept of Biochem/LabMedPath *Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?) Are you an established PI ready to move to 🇨🇦? research.utoronto.ca/funding-oppo...

Next week will be the FEBS Advanced Lecture Course 'Emerging insights from structural biology into molecular mechanisms of diseases', where I will present new structural biology and protein engineering results at the 'Academia meets industry' session. Hope to see you there!

Liposome Encapsulation Enables Near-Native Cryo-EM Structural Determination by Shielding Macromolecules from Non-Physiological Interfaces www.biorxiv.org/content/10.1101/2025.05.06.652550v1 #cryoem

Nice work on coronavirus HKU1-A spike opening by Min Jin et al.: www.nature.com/articles/s41... With a longer glycan and higher resolution structures, they nicely confirm our conclusions (www.nature.com/articles/s41...) and add new insights.

Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach. More details: www.nature.com/naturecareer... Apply by 04 MAY #PostdocJobs #ScienceJobs

Air pollution has dropped significantly in #Paris in the last 15 years as a result of a deliberate strategy. Mayor @annehidalgo.bsky.social’s leadership has traded car space for green space, safe bike space, kid space.. and traded pollution for people. Good trade.

Wat een serpent... Faber geeft geen goedkeuring voor lintjes COA-medewerkers - nos.nl/l/2561674

MAR added DT DT: Covfefe MAR removed DT from the group

👊🏴‍☠️🔥 🤪

Ketamine is one helluva drug

French researcher, going to a conference in Houston, was forbidden entry to US; his work and personal electronics were both confiscated. Why? Because a “random search” of his cell phone revealed a negative personal opinion on Trump and the Trump administration. www.lemonde.fr/internationa...