Jan Binovsky
@jbinovsky.bsky.social
📤 1009
📥 1238
📝 42
🇸🇰PhD student at Plevka Lab, CEITEC_Brno🇨🇿 | biochemistry & structural biology 🧬🧫🧪🔬
reposted by
Jan Binovsky
Microbes.Info
2 months ago
High-Resolution
#virus
blueprint offers new hope against
#antibiotic
resistance ... |
#antibioticresistance
|
#bacteria
|
#bacteriophages
|
#phage
| By
@universityofotago.bsky.social
via scitechdaily .com
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Stunning High-Resolution Virus Blueprint Offers New Hope Against Antibiotic Resistance
A detailed 3D map of a bacteria-hunting virus reveals ancient origins and new promise against superbugs.
https://scitechdaily.com/stunning-high-resolution-virus-blueprint-offers-new-hope-against-antibiotic-resistance/
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reposted by
Jan Binovsky
Aritz Roa-Eguiara
2 months ago
🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process.
www.biorxiv.org/content/10.6...
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Much needed addition to the AlphaFold Database! 💻 Large potential for use in
#StructuralBiology
#Phage
research.
add a skeleton here at some point
12 months ago
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Always happy to provide "wonderfully bad mmCIF files" to make
#chimeraX
better!
about 1 year ago
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Nice work and awesome
#scicomm
thread!
add a skeleton here at some point
about 1 year ago
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reposted by
Jan Binovsky
Ed Hutchinson
over 1 year ago
Our study on pasteurising influenza viruses in milk is now out! It's a nice simple story: influenza viruses (including H5N1) are killed really effectively by pasteurisation, but in raw milk they stay infectious - obvious public health implications of both points... (1/2)
rdcu.be/d73te
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reposted by
Jan Binovsky
Rita Strack
over 1 year ago
I'd like to draw your attention to this truly excellent paper from the Taraska lab on cryoET of plasma membrane associated proteins. Everyone who is thinking about probes in the cryoET space should also see what they could do with ferritag (fig 6)
www.nature.com/articles/s41...
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I appreciate the stats! Thanks,
@pdbeurope.bsky.social
for a summary!
add a skeleton here at some point
over 1 year ago
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reposted by
Jan Binovsky
Janet Iwasa
over 1 year ago
I'm happy and humbled to take on a new role with
@rcsbpdb.bsky.social
. I'll be continuing David Goodsell's work on the Molecule of the Month, starting with my first article on Assembly Line Polyketide Synthases! Check it out (animation included!)
pdb101.rcsb.org/motm/301
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PDB101: Molecule of the Month: Assembly Line Polyketide Synthases
Large multienzyme complexes that synthesize diverse small molecules in a stepwise manner.
https://pdb101.rcsb.org/motm/301
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Amazing work and resource! 😍
add a skeleton here at some point
over 1 year ago
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reposted by
Jan Binovsky
Fabian Eisenstein
over 1 year ago
SPACEtomo v1.2 is online!
github.com/eisfabian/SP...
- Improved GUIs for lamella detection, target selection and CLEM registration make it the best target selection workflow for PACEtomo on any kind of lamella sample. - Easier installation and configuration Any feedback is much appreciated! :)
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🎄Xmas office cleaning 🗑️ ...and how do you organize your thoughts? 🫵
#PhDlife
#PhDSky
#mindmap
over 1 year ago
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I knew it wouldn't be long before we see
#cryoEM
structures of a
#phage
cousin infecting
#Archea
🦠 🧪 Beautiful structures from
@daumlab.bsky.social
, congrats!
add a skeleton here at some point
over 1 year ago
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Dear
#StructuralBiology
#PhD
#PostDoc
peers, join in!
add a skeleton here at some point
over 1 year ago
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Another useful starter pack 👇
add a skeleton here at some point
over 1 year ago
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In case someone is looking for this...
add a skeleton here at some point
over 1 year ago
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Just uploaded a revised version of the manuscript on bioRxiv 🙌 We made some changes to the text and figures, mainly to clarify the naming of proteins. Yeah, it's a challenge to describe things within two different 10MDa structures 🐘
add a skeleton here at some point
over 1 year ago
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🚀Announcing my first (co)first-author manuscript 🚀 "Cell attachment and tail contraction of S. aureus phage phi812" 🔗
bit.ly/Phi812
Explore the structural details of phage interaction with Gram+ bacteria 🤯
#PhageTherapy
#cryoEM
🧪 | 🧬🧶 | 🦠 1/11
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Cell attachment and tail contraction of S. aureus phage phi812
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
https://bit.ly/Phi812
over 1 year ago
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Reading a lot about contractile phages and injection systems, the idea of leveraging them for cargo delivery always amazed me 🤯 and it's no longer just an idea 🧪 Here, a T. gondii secretion system was hijacked to deliver therapeutic proteins to neurons. Link to study:
rdcu.be/dQozB
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Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons
Nature Microbiology - Toxoplasma gondii secretion systems can be engineered to deliver multiple large therapeutic proteins to neurons in vitro and in vivo.
https://rdcu.be/dQozB
almost 2 years ago
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Using MS Word's "Dictate" function these days: "I did an internshit..." "I learned to cry electron microscopy" ...how am I supposed to write a motivation letter with this? 😢
almost 2 years ago
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reposted by
Jan Binovsky
Kristian G. Andersen
almost 2 years ago
Really good 15 min TWiV episode with Paul Offit outlining how false and irresponsible the recent lab leak nonsense from
@nytimes.com
is. I for one appreciate the brevity - there really is nothing more to it. If you're interested in the topic, give it a listen.
www.youtube.com/watch?v=Ukv9...
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Beyond the Noise #40: Lab leak mania
In this episode Dr. Offit asks, why did the New York Times publish an op-ed supporting the lab leak theory when all evidence supports a zoonotic spillover?Sh...
https://www.youtube.com/watch?v=Ukv9H6iAn7A&list=WL&index=2
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Manuscript submitted 🤞 Brace for new structural insights into a bacteriophage landing onto the host cell 🚀
almost 2 years ago
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📰 I find myself questioning my scientific career from time to time. This is an encouraging piece. "Meaningfulness in a scientific career is about more than tangible outputs."
www.nature.com/articles/d41...
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Meaningfulness in a scientific career is about more than tangible outputs
Letter to the Editor
https://www.nature.com/articles/d41586-024-00827-w
about 2 years ago
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Just finished registration for the Gordon Research Seminar (GRS), complementing the conference (GRC) on 3D
#ElectronMicrocopy
🔥 Looking forward to attending the GRC/S for the first time! Am I gonna meet someone from my BlueSky bubble? 🙌
about 2 years ago
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📰 Some positive news for the afternoon reading: a survey about trust in scientists. "...trust levels are fairly high across a range of demographics." "It’s about the leadership of political parties and how they treat scientists."
www.nature.com/articles/d41...
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Largest post-pandemic survey finds trust in scientists is high
Study of more than 70,000 people suggests that trust levels vary among countries and are linked to political orientation. Study of more than 70,000 people suggests that trust levels vary among countri...
https://www.nature.com/articles/d41586-024-00420-1
over 2 years ago
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reposted by
Jan Binovsky
Kaitlyn Abe
over 2 years ago
I am excited to share that my work with
@cijilim.bsky.social
on protecting fragile samples from air-water-interface damage during cryo-EM plunge freezing is in preprint!
www.biorxiv.org/content/10.1...
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POV: renaming protein chains in your model. Symmetry mates not included.
over 2 years ago
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🚨 Scientific Illustrator Needed 🚨 I'm seeking a skilled illustrator to visualize a cool phage structure using molecular animation in 3D, ideally something dynamic, if possible. Please share and drop suggestions! What details should I provide initially, and what are typical timelines & costs?
over 2 years ago
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My colleague, a structural biologist skilled in cryoEM and cryoET, is looking for a postdoc in 🇪🇺 Despite her outstanding CV, apparently, 🇷🇺 passport seems to be a hurdle. Any recommendations for open-minded institutions?
x.com/LMumrik/stat...
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https://x.com/LMumrik/status/1749683236765147339?s=20
over 2 years ago
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