A beautiful journey through the nuclear pore complex with #cryoET - samples prepared via the Arctis Cryo-Plasma-FIB, data collected with the Glacios Cryo-TEM and segmented in Amira Software. #TeamTomo - See what’s possible with 200 kV cryo-ET: ter.li/n2a8i5po

"Why paying peer reviewers works, according to a journal’s editor-in-chief" I wonder if this is going to change anything.....old idea, new data, uncertain impact. Your thoughts? www.nature.com/articles/d41...

🔥My first (co)first-author paper is out🔥 The surfaces of Gram+ and Gram- bacteria are markedly different from each other. How are phages equipped to breach the Gram+ envelope❓ 💡We report a baseplate structure uniquely adapted to infect Gram+ S. aureus. A 🧵⬇️ 1/8 #phagesky #cryoEM 🧪

I love when real life issues get explained by science (scientists) so elegantly 👏🏻

High-Resolution #virus blueprint offers new hope against #antibiotic resistance ... | #antibioticresistance | #bacteria | #bacteriophages | #phage | By @universityofotago.bsky.social via scitechdaily .com

🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process. www.biorxiv.org/content/10.6...

Much needed addition to the AlphaFold Database! 💻 Large potential for use in #StructuralBiology #Phage research.

Always happy to provide "wonderfully bad mmCIF files" to make #chimeraX better!

Nice work and awesome #scicomm thread!

Our study on pasteurising influenza viruses in milk is now out! It's a nice simple story: influenza viruses (including H5N1) are killed really effectively by pasteurisation, but in raw milk they stay infectious - obvious public health implications of both points... (1/2) rdcu.be/d73te

I'd like to draw your attention to this truly excellent paper from the Taraska lab on cryoET of plasma membrane associated proteins. Everyone who is thinking about probes in the cryoET space should also see what they could do with ferritag (fig 6) www.nature.com/articles/s41...

I appreciate the stats! Thanks, @pdbeurope.bsky.social for a summary!

I'm happy and humbled to take on a new role with @rcsbpdb.bsky.social. I'll be continuing David Goodsell's work on the Molecule of the Month, starting with my first article on Assembly Line Polyketide Synthases! Check it out (animation included!) pdb101.rcsb.org/motm/301

Amazing work and resource! 😍

SPACEtomo v1.2 is online! github.com/eisfabian/SP... - Improved GUIs for lamella detection, target selection and CLEM registration make it the best target selection workflow for PACEtomo on any kind of lamella sample. - Easier installation and configuration Any feedback is much appreciated! :)

🎄Xmas office cleaning 🗑️ ...and how do you organize your thoughts? 🫵 #PhDlife #PhDSky #mindmap

I knew it wouldn't be long before we see #cryoEM structures of a #phage cousin infecting #Archea 🦠 🧪 Beautiful structures from @daumlab.bsky.social, congrats!

Dear #StructuralBiology #PhD #PostDoc peers, join in!

Another useful starter pack 👇

In case someone is looking for this...

Just uploaded a revised version of the manuscript on bioRxiv 🙌 We made some changes to the text and figures, mainly to clarify the naming of proteins. Yeah, it's a challenge to describe things within two different 10MDa structures 🐘

🚀Announcing my first (co)first-author manuscript 🚀 "Cell attachment and tail contraction of S. aureus phage phi812" 🔗 bit.ly/Phi812 Explore the structural details of phage interaction with Gram+ bacteria 🤯 #PhageTherapy #cryoEM 🧪 | 🧬🧶 | 🦠 1/11

Reading a lot about contractile phages and injection systems, the idea of leveraging them for cargo delivery always amazed me 🤯 and it's no longer just an idea 🧪 Here, a T. gondii secretion system was hijacked to deliver therapeutic proteins to neurons. Link to study: rdcu.be/dQozB

Using MS Word's "Dictate" function these days: "I did an internshit..." "I learned to cry electron microscopy" ...how am I supposed to write a motivation letter with this? 😢

Really good 15 min TWiV episode with Paul Offit outlining how false and irresponsible the recent lab leak nonsense from @nytimes.com is. I for one appreciate the brevity - there really is nothing more to it. If you're interested in the topic, give it a listen. www.youtube.com/watch?v=Ukv9...

Manuscript submitted 🤞 Brace for new structural insights into a bacteriophage landing onto the host cell 🚀

📰 I find myself questioning my scientific career from time to time. This is an encouraging piece. "Meaningfulness in a scientific career is about more than tangible outputs." www.nature.com/articles/d41...

Just finished registration for the Gordon Research Seminar (GRS), complementing the conference (GRC) on 3D #ElectronMicrocopy 🔥 Looking forward to attending the GRC/S for the first time! Am I gonna meet someone from my BlueSky bubble? 🙌

📰 Some positive news for the afternoon reading: a survey about trust in scientists. "...trust levels are fairly high across a range of demographics." "It’s about the leadership of political parties and how they treat scientists." www.nature.com/articles/d41...

I am excited to share that my work with @cijilim.bsky.social on protecting fragile samples from air-water-interface damage during cryo-EM plunge freezing is in preprint! www.biorxiv.org/content/10.1...

POV: renaming protein chains in your model. Symmetry mates not included.

🚨 Scientific Illustrator Needed 🚨 I'm seeking a skilled illustrator to visualize a cool phage structure using molecular animation in 3D, ideally something dynamic, if possible. Please share and drop suggestions! What details should I provide initially, and what are typical timelines & costs?

My colleague, a structural biologist skilled in cryoEM and cryoET, is looking for a postdoc in 🇪🇺 Despite her outstanding CV, apparently, 🇷🇺 passport seems to be a hurdle. Any recommendations for open-minded institutions? x.com/LMumrik/stat...