Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam. Try the demo here: store.steampowered.com/app/4045010/... Give Muyuan feedback: steamcommunity.com/app/4045010 #ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

SPEAR (bacterial nanosynringe) enables loading of different types of cargo (including folded ribonucleoproteins and single-stranded DNA) and targeting of defined cell types both in vitro and in vivo www.nature.com/articles/s41... @natbiotech.nature.com @zhangf.bsky.social

🚨 One week left to apply! I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen Come work with a great team and exciting projects in a collaborative environment! 🔗 Links to the ads in comments #CryoEM #AcademicJobs

Great resource! 😃

Looking for a Post doc position in Structural Biology? We are hiring! See post here: jobbank.dk/job/2850337/... The task is to continue our endeavor in solving cryo-EM structures of the human dopamine transporter. See: doi.org/10.1038/s415... Thanks to the Novo Nordisk Foundation for funding.

Very nice structure of the entire extracellular part of bacterial flagellum. Time to update my plant immunity teaching slides with the exact position of flg22 in the intact flagellum. www.nature.com/articles/s41...

We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩 www.nature.com/naturecareer...

Manuscript/resource alert #microsky 🦠 My lab offers the community a collection of 30 E. coli (CloneFISH) cultures, each carrying a plasmid for the heterologous expression of a (near) full-length 16S rRNA gene from one of 30 lineages of archaea, including 19 yet uncultured ones.

Running Phenix and stuck? Now you can ask the new Phenix chatbot anything from the 600-page tutorial about how to run any program. Big thanks to Tom Willinger for making this happen! Try it out: phenix-online.org/version_docs...

Excited to see our work published in @ScienceAdvances ! We present RBPseg, a method for structural prediction of #phage receptor-binding proteins. We applied it to diverse tail fibers and validated the predicted structures using #cryoEM. Read here: www.science.org/doi/10.1126/...

RBPseg: Toward a complete phage tail fiber structure atlas pubmed.ncbi.nlm.nih.gov/40479047/ #cryoem

In case you missed our May webinar, it is now available!! Ellen Zhong from Princeton University presented CryoDRGN-AI. Topic: CryoDRGN-AI: Neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets Host: Pete Meyer Recorded on: May 20, 2025 buff.ly/jKjWTOa #SBGridWebinars

The short version is: take the receptor or system you care about, make a strain with that knocked out or modified and a fluorophore, and the wildtype or different knockout with a different fluor. Look for differential plaquing. And it works!

Do you have any “published” E. coli phage? and willing to share for academic research? most phages from yr 1980-2015 ish aren’t even available to researchers. they are either lost bcz of not sharing or archiving in registries.

I know I haven't been active on here much lately but...I am hiring a core facility postdoc to own the Krios, do a lot of cryoET jobs.rutgers.edu/postings/249...

Amazing work 🔥

Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Join the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩 Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭! Please visit my lab's webpage for details about the position and how to formally apply.

🚨Super happy to see this preprint out!! Main part of Leyre’s PhD journey on the eCIS from Photorhabdus luminescens. Full structure using #cryoEM Check it out! 🎊 www.biorxiv.org/content/10.1...

#TeamTomo is going to be all over chromatin structure and organization in the next years. Beautiful efforts like this are only the beginning! 🧪🧶🧬🔬

The BASEL collection of E. coli #phages is limited by its host strain. @humollidorentina.bsky.social @damienpiel.bsky.social @aharms485.bsky.social &co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity @plosbiology.org 🧪 plos.io/4jirGvX

Repost appreciated: Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics. Deadline 4 May. More info: www.carlsonlab.se/join/

Tried my hand at sculpting for the first time ever, a T4 Bacteriophage, well pleased with the results and even happier with the enjoyment and focus it gave me whilst sculpting. Now the nervous wait to see if it cracks while it air dries over the next few days. #sculpture #airdryclay #art

biorxiv.org/content/10.1... We found ubiquitous recombinases from cryptic prophages may invert DNA to form new, chimeric proteins that inhibit phages by blocking adsorption. Congratulations to Joy, Daniel, Rodolfo and Michael for their strong efforts.

Gemma Solomon and I are looking for a postdoc to work across the two groups on modelling biological systems with a view to applications for quantum computing More details about the project including how to apply in the link below. Deadline April 9 2025 candidate.hr-manager.net/ApplicationI...

It's going well. #phdchat #phdjourney #phd #phdstudent #phdlife #thesis #academicsky

Very nice thread and worth to have a look!

Been thinking about creating a collection of good protein structure figures, as inspiration for my own work. #1 www.nature.com/articles/s41...

🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵

Moorhen Gallery has gone live! Click on an image and Moorhen will download into your browser the data, model and session files to reproduce the figure - so you can see how it's made. Get in touch with @lulu_catapano in the other place if you want to make a contribution to the gallery!

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

We are very pleased to share our latest preprint on the architecture of the membrane complex of the type 7 secretion system involved in bacterial competition in B. subtilis. #CryoEM #microsky

Hi, Vox reporter here: If you've had a study section, NIH travel, or other NIH-related meeting cancelled (or not), raise your hand! Reply or DM me, and repost for visibility if you're able. #academicsky @drugmonkey.bsky.social

🚨 🌟 Submissions & Registrations Open for #ViBioM2025! 🌟 🚨 Join us 13–15 May 2025 in Lisbon, Portugal! 🦠💻 Present your research, connect with global experts, and shape the future of #Virology & #Bioinformatics. 📅 Details & links: evbc.uni-jena.de/events/vibio...

Cool!

Cryo-EM facility in Umeå, Sweden :)

👋 Hi antiphage defense community, we are soon releasing an update of DefenseFinder. We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things. Please answer wt preprints/papers with new systems or mail/git them to us. 🙏

Become our colleagues in Umeå! Great community, great facilities.

Awesome 👇

The NKI call for PhD students is now open, with more information on our project on the website, More info: bit.ly/3O4bOjq

Interesad@ en estructura de virus, biofísica, biología computacional? Tienes una media de grado >8 y quieres solicitar un contrato postdoctoral? Contacta con nosotr@s! Más info en www.cnb.csic.es/investigacio... www.infosubvenciones.es/bdnstrans/GE... www.infosubvenciones.es/bdnstrans/GE...

We are hosting a cryo-EM grid nanofabrication workshop on 28 April 2025, as part of the Canadian Cryo-EM Nexus (ccemn.ca). Learn how to make holey gold or holey carbon grids in your own laboratory! Space is limited, so please apply at web.cvent.com/event/ee88ac...

This is true not only for PhD students. Speaking from experience 😅 p.s. bouldering is still an excellent hobby

What a great way to end the year! ✨ Today in @cellpress.bsky.social we report the structure and function of the Shedu anti-phage defense system. tinyurl.com/4crj6dnx A long 🧵...

🚨PhD Opportunity - please share!🚨 We’re hiring a PhD student to start Sept 2025: how do bacteria ‘tame’ phage parasites, and turn them into deadly Tailocins? Come join me, @brockhurstlab.bsky.social, Patrick Cai & @raveentank.bsky.social as we study ZOMBIE PHAGES! findaphd.com/phds/project...

The structure of Zorya is mind-blowing 🙀 www.nature.com/articles/s41...

Glad to finally share the published manuscript on Zorya #phagedefence system. Outstanding work by Haidai Hu and Philipp F. Popp on this challenging system. Happy to have contributed and thankful to all the collaborators 🍾🎊 www.nature.com/articles/s41...

Registration now open for the EMBO Workshop: Immune System of Bacteria !!!! www.sisb2025.conferences-pasteur.org/home Joins us in Institut Pasteur, Paris, April 8-10th.

Structural biology people: @ucsfchimerax.bsky.social has entered the building.