Dorentina Humolli
@humollidorentina.bsky.social
📤 153
📥 139
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PhD student studying phage-host interactions at ETH Zürich | Lab of Molecular Phage Biology
reposted by
Dorentina Humolli
Enea Maffei
16 days ago
1/6 👻 Something strange in your liquid agar? Who you gonna call? Thermophile hunters. Our new
@asm.org
#MRA
paper reports the complete genome sequence of Geobacillus stearothermophilus strain CS7089 isolated from a commercial agar preparation.
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reposted by
Dorentina Humolli
Luuk Loeff
20 days ago
Happy to share our latest pre-print on the Druantia defense system. We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
A🧵
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https://www.biorxiv.org/content/10.64898/2026.05.13.724313v1
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reposted by
Dorentina Humolli
Nature Microbiology
3 months ago
Out Now! Conditional activation of Cas13 enforces lysogeny in a native type VI-A CRISPR host
#MicroSky
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Conditional activation of Cas13 enforces lysogeny in a native type VI-A CRISPR host
Nature Microbiology, Published online: 10 March 2026; doi:10.1038/s41564-026-02288-5RNA-targeting CRISPR in Listeria seeligeri restricts the lytic cycle of temperate phages but tolerates prophage acquisition while also preventing induction—a system that enables acquisition of beneficial prophages while mitigating the risks of lysis.
https://go.nature.com/3NvD1yD
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reposted by
Dorentina Humolli
Aritz Roa-Eguiara
3 months ago
🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process.
www.biorxiv.org/content/10.6...
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reposted by
Dorentina Humolli
bioRxiv Microbiology
3 months ago
Phage-encoded CasPRs transcriptionally silence diverse CRISPR-Cas systems
https://www.biorxiv.org/content/10.64898/2026.02.23.707548v1
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reposted by
Dorentina Humolli
Alexander Harms
6 months ago
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
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🚀New preprint from our lab! I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡 Continue reading (🧵)
6 months ago
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reposted by
Dorentina Humolli
Emmanuele Severi
7 months ago
#mycrosky
#synbio
www.biorxiv.org/content/10.1...
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Adapting CRISPR-associated transposons for rapid and high-throughput reverse genetics
CRISPR-associated transposons (CAST) use guide RNAs to direct their transposition and are being harnessed as tools for programmable genome engineering across diverse bacterial species. However, CAST s...
https://www.biorxiv.org/content/10.1101/2025.10.31.685825v1
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reposted by
Dorentina Humolli
Osterman Ilya
7 months ago
Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides. Here’s the story of how we discovered the Metis defense system 👇
www.biorxiv.org/content/10.1...
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reposted by
Dorentina Humolli
bioRxiv Microbiology
7 months ago
Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses
https://www.biorxiv.org/content/10.1101/2025.11.13.688357v1
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Dorentina Humolli
Nitzan Tal
11 months ago
📢Preprint out! Excited to share my final work from the
@soreklab.bsky.social
! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!
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reposted by
Dorentina Humolli
Molly Gale (Gale-Hammell Lab)
12 months ago
Most people fail to appreciate just how groundbreaking McClintock's work truly was. Her transposon work was first presented in 1950 - before we knew, for example, "DNA is the genetic material." Long before most discoveries that we consider fundamental to the question of: "What is a gene?"
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reposted by
Dorentina Humolli
PLOS Biology
about 1 year ago
The BASEL collection of E. coli
#phages
is limited by its host strain.
@humollidorentina.bsky.social
@damienpiel.bsky.social
@aharms485.bsky.social
&co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity
@plosbiology.org
🧪
plos.io/4jirGvX
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reposted by
Dorentina Humolli
Alexander Harms
over 1 year ago
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
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