A co-evolved peptide-GPCR system senses host entry to drive fungal infection https://www.biorxiv.org/content/10.1101/2025.09.26.678928v1

🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT! She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...

A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by @JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...

Our researchers are looking into the past to protect UK wheat from a new fungal rust threat — searching for resistance genes in historic wheat lines to safeguard harvests and reduce the need for fungicide applications.

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Now published in Plant Pathology. 'Molecular Investigation of Rlm3 From Rapeseed as a Potential Broad‐Spectrum Resistance Gene Against Fungal Pathogens Producing Structurally Conserved Effectors' - Talbi - Plant Pathology - Wiley Online Library bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...

A milestone for plant genomics just out @natgenet.nature.com 130 bryophyte genomes! www.nature.com/articles/s41...

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

Are you interested in the mechanisms of mRNA regulation in the early embryo and are looking for a great lab to start your PhD? Then check out this amazing opportunity with my outgoing postdoc @lorenzoorts.bsky.social who will start her own lab - I can highly recommend to apply!

For something different, tried this approach on something on the other end of the spectrum - in situ ribosomes from low SNR 2DTM data. Used the U2OS-grid 9 dataset from EMPIAR-12459 (699 movies; doi.org/10.1016/j.mo...). Blob pick & 2D after denoising gave 12k particles. 2-class HR-HAIR --> 3.3 Å

This looks like a great opportunity: #Tenure-track assistant #professor position at University of Lausanne on #MPMI career5.successfactors.eu/career?caree...

Call for a tenure-track position at our Department of Plant Molecular Biology in Lausanne! We are searching for promising early-career researchers in the broad field of plant-organismal interactions. Deadline: November 30, 2025 - Please re-post! career5.successfactors.eu/career?caree...

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching! Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv! www.biorxiv.org/content/10.1...

Another successful approach to the same problem as HR-HAIR! 🤩 I wonder if a combo might be worth a try - use one frequency band to get perfectly centered particles using 2DTM, then re-estimate orientations using HR-HAIR with a non-overlapping frequency band?

Me when I get the reviews for the paper/grant back…

New Letter: "An apoplastic fungal effector disrupts N-glycosylation of ZmLecRK1, inducing its degradation to suppress disease resistance in maize" rdcu.be/eGD4E A fungal effector promotes a cell-surface receptor autophagy-mediated degradation to dampen plant immunity.

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

Just planted in @jcellsci.bsky.social 🌳 😍 An A. thaliana mutant lacking all nine #ATG8 isoforms provides genetic evidence for functional specialization of #ATG8 in plants forest.biologists.com/landscape/?i...

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

We are pleased to announce that @talbotlabtsl.bsky.social has been awarded the RKS Wood Prize 2026 by the @bspp.bsky.social. “I am humbled to have been awarded the RKS Wood Prize 2026. I’d like to thank my research group and my TSL colleagues for their inspiration and support.” buff.ly/VvoR27Q

Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer

📢 Job alert! #PlantSciJob We are opening a Professorship (W1-TT) in Plant Biochemistry at the ZMBP @unituebingen.bsky.social Apply by October 17th Please spread the word! More info 👇 uni-tuebingen.de/fakultaeten/...

📢 A Junior Professorship (W1, tenure track) is open at the Center for Plant Molecular Biology at Uni Tübingen (@zmbp-tuebingen.bsky.social) — to work on plant protein biochemistry (composition, structure, dynamics, or regulation of protein complexes). 🌱 Great opportunity — Apply by Oct 17th!

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

Our latest work on how chloroplasts contribute to immunity: Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses url: academic.oup.com/plcell/artic...

The BM^2 Lab is hiring a Ph.D. student to work on a variety of problems connected to modeling of morphogenesis in plants (i.e. ovule curvature formation, fixed handedness establishment in certain plant organs and its link to cell wall mechanics). Please share!

This shit is insidious in academia and prevents collective organizing. I tell my colleagues exactly how much I make whenever they ask. Never hide your salary from your comrades.

Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org ! www.science.org/doi/10.1126/...

I am extremely happy and honoured to share with you that I received an #ERCStG! It has been an amazing journey. 🤘 Thank you so much for the encouragement and support from mentors, colleagues, friends and family during my career through different countries in Europe. 🇪🇺🇩🇪🇬🇧🇨🇭🇳🇱 1/3

Amazing #CelebratingAlumni news this week (Thread) (1/3) Clemence Marchal @ClemMarchal received an @ERC_Research Starting Grant -- CooPAIRation "Optimised plant immune receptor pairs" erc.europa.eu/news-events/...

Super excited and honoured to have been awarded an ERC Starting Grant for CooPAIRation! How do plant immune receptors work together to trigger an immune response? Can we modulate immune responses for disease resistance? We will tackle these questions in CooPAIRation Positions to be announced soon!

I am thrilled &honoured, what a journey that was! Only possible with the great support from family, all lab members, friends, current @unicologne.bsky.social / @ceplas.bsky.social & former colleagues & mentors. With this project, we will do all that we can to help protect plants from diseases (1/2)

Dr. Joel Frohlich vom fMEG-Zentrum der Medizinischen Fakultät und Dr. Clémence Marchal vom @zmbp-tuebingen.bsky.social haben jeweils einen Starting Grant des @erc.europa.eu eingeworben! Herzlichen Glückwunsch! 👏 Mehr Infos: 👉 uni-tuebingen.de/universitaet... #ERCStartingGrants #Molekularbiologie

Wow - congrats to all plant scientists! @izzysaurlab.bsky.social @pfeilmeier.bsky.social @jiorgoskourelis.bsky.social @clemmar.bsky.social @vinayshukla.bsky.social @tinaschreier.bsky.social so great to see 🌱s being rewarded the ERC StG!

I've read the abstract 3 times and I still don't understand the phenomenon www.nature.com/articles/s41...

Our new paper is out in New Phytologist! We describe how the Ralstonia solanacearum effector RipAV suppresses plant immunity by directly interfering with key defense regulators. 🧵👇 nph.onlinelibrary.wiley.com/doi/10.1111/...

Good ol' HMAs keep on binding effectors 💎

Check out our new pre-print! ✨ We cloned AvrWTK4, the first wheat powdery mildew effector recognised by a tandem kinase protein, and show that an HMA-like integrated domain in WTK4 acts as pathogen decoy. Discover the whole story on bioRxiv ⬇️

Every few months the "good lab hands" thing comes up and it misses a key point: you can learn to have good hands. Training matters. Good hands aren't some magic gift from the PCR gods, you have to develop them through directed repetitive practice, like any other skill

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social

We’re a bunch of amateur psychologists… #AcademicChatter #phdchat

👉 my.corehr.com/pls/uoxrecru... Join us and be part of shaping the future of #plantscience at Oxford as we move to the new Life and Mind Building lifeandmind.web.ox.ac.uk/home (recognised for its potential to change the World edition.cnn.com/2025/01/01/s...) @biology.ox.ac.uk www.biology.ox.ac.uk

🌟 𝐅𝐢𝐫𝐬𝐭 𝐰𝐚𝐯𝐞 𝐨𝐟 𝐜𝐨𝐧𝐟𝐢𝐫𝐦𝐞𝐝 𝐤𝐞𝐲𝐧𝐨𝐭𝐞 𝐬𝐩𝐞𝐚𝐤𝐞𝐫𝐬 🗣️ Excited to share the first members of our keynote lineup! 🔹 Federico Ariel 🔹 Brian Gregory 🔹 Polly Hsu @pollyhsulab.bsky.social 🔹 Rosa Lozano-Durán @geminiteamlab.bsky.social 🔹 Hervé Vaucheret More speakers and more info coming soon!

In situ architecture of the endosymbiont Wolbachia pipientis https://www.biorxiv.org/content/10.1101/2025.08.29.673095v1

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...