TIL ChimeraX has a feature where you can load an alphafold2 structure and PAE and it will show you contacts below a distance you set and show you the PAE for those distances. www.youtube.com/watch?v=TMcj...

💙💛 UM friends: Do you know that you can publish in many scientific journals for free due to UM open access agreements? We've saved something like $20,000 this year in APCs 🎉 😮❗ Here's a searchable database of journals: apc.lib.umich.edu ( @ummni.bsky.social , @umichresearch.bsky.social )

Just got a notice of award for an R01. I will be hiring. I'll be looking for either a staff scientist or postdoctoral researcher. The project explores the conserved HEATR5 family of proteins. Their roles in AP1 mediated traffic, and links to motors.🎉

The whole "science is slowing down" discourse is deeply frustratingly to me. Advocates betray a small-minded view of science that is inherently "extractive", and they assume we can accurately measure scientific understanding with shitty citation data. I'm ashamed by science of science's involvement

Jeff Macher and colleagues have shown that for patents, the putative "decline" in disruption is primarily the result of dropping older data and the number of highly disruptive patents has actually *increased* since 1980 www.sciencedirect.com/science/arti...

Orthogonally related, my own work with @bihutchins.bsky.social and our colleagues shows that the number of scientific breakthroughs per year is actually amazingly consistent over a 20 year time frame www.biorxiv.org/content/10.6...

New online: A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling

Membrane Trafficking Seminar series returns with two talks on how membranes organise, move, and shape cellular life. Final session until September! Join @felixmendu.bsky.social @franbottanelli.bsky.social and me for an afternoon of cell biology at its best. felixcampelo.wixsite.com/membranetraf...

Reminder — UW #Microbiology has an open search for an Assistant Professor, focusing on fundamental problems in #bacteriology! If you or someone you know would be suitable, here's the ad: apply.interfolio.com/185622

Limiting the number of NIH RPG a person can serve as PI does two things, ~immediately. It kills any interest in MPI proposals that remained after the 6-proposal limit. It kills interest in R03 and R21 proposals.

Damage control or the worst timing ever?

Less than one week left to submit your ReproBioArt 2026 contest images!!! Look at these stunning images of beautifully organized testis tissue (left) and actin cytoskeletal organization in rhesus oocyte (right) 🤩

🧪(reposting for the morning crowd) We want to purify our own Cas9. I know there's a lot of 'improved' Cas9's. Any recommendations of a good one?

🧪We want to purify our own Cas9-maybe an improved version. What're ppl using these days?

🧪Does anyone else have problems reading MBoC papers online? The frame takes up my 1/2 of the browser screen! Is there any solution beyond downloading the pdf? I have this problem in edge, chrome, and duckduck browsers. @ascbiology.bsky.social

If you are an ASCB member, please consider nominating a junior colleague with a strong, promising research program who is already demonstrating leadership in their field, department, and the broader community for the WICB Junior Award for Excellence in Research. www.ascb.org/award/women-...

🧪Has anyone ever replaced the upper bearings on an orbital shaker? The upper bearing is bolted to a lower bearing. I need to remove the upper one, but the lower one rotates. Do I just hold the lower one with a wrench and unbolt the upper or is there something I'm missing?

had one and was legitimately shocked at how not horrible the prep is. always heard you have to starve yourself but you can just load up on jello and popsicles and not be especially hungry.

I have a rare genetic condition that increases colon cancer risk, so I’ve had many colonoscopies and agree completely. a key benefit is that if they see something that looks like it may become cancer, they can zap it before it does. Very rare to be able to intervene pre-cancer, take advantage!

Done. Very much hoping that I can withdraw this one because the previous version gets funded.

Has anyone observed mNeonGreen getting brighter after photobleaching?

Quick question for my MD friends: how did/do you get healthcare in med school? Is it offered? Required?

CT technician position available at the U-M Museum of Zoology/Department of Ecology and Evolutionary Biology: careers.umich.edu/job_detail/2...

'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.' link.springer.com/article/10.1...

Ghaaaa--you can install endnote on the work computer through our enterprise management portal but you can't link it to word. For that you need elevated privileges, like why tempt me that I can load it if I can't use it. Guess I'm heading into work tomorrow to add new references to the grant.

Lately I’ve been in an indie team making stop-motion animation. It’s just 4 of us (animator, writer, voice actor, sound designer). The show’s called The Tiny Angry Witch. It’s all basically hand made. No AI. It’s tiring, but we love what we do. So, anyway, here’s a Witch making rude noises:

This is an interesting analysis of AlphaFold3. I don't claim to understand all of the technicalities, but the conclusion matches our own anecdotal experience that evolutionary depth is important for the most confident AlphaFold predictions. www.biorxiv.org/content/10.6...

So much is crummy, but the first fireflies are out tonight! Bon viva little ones!

Reposting for the afternoon folks. My student & I need to interview people at companies to figure out what it takes to get our product from academic laboratory to commerical use. If you work for a biotech company, ecotoxicant cleanup co, or even something tangentially related, please dm/reply. Thx!

Excited to share this paper from @yiechanglin.bsky.social showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. 🎥🌟 #MDsimulations #StructuralBiology doi.org/10.1016/j.bp...

UK-based cell biologist? Interested in membrane trafficking? Want to find a conference? Looking for a job (PI, postdoc...)? Do link to www.ukmembranetraffic.com, where @jezcarlton.bsky.social and Chris Stefan (not here?) do sterling work

🧪PSA-if you are going up for tenure, make sure that your website is up to date with your recent publications NOW!! Yes, your letter writers will get your dossier, but often only AFTER they agree to write. They might look at your website before making that decision.

A wonderful opportunity!

A thought inspired by the anniversary of Mt. St. Helens eruption. I was 8 and fishing with my dad in eastern Washington. I have a harrowing story of how we got home. Everyone in my hometown has a story about the Mt. St. Helens eruption. 1/🧵

Are you planning to spend an extended amount of time in the sun soon? Remember, friends don’t let friends get a sunburn. Here’s your safe summer checklist: ✔️ sunscreen ✔️ sunglasses ✔️ hat ✔️ protective clothing ✔️ shade #DontFryDay!

'Endosomal-lysosomal network dysfunction in neurodegeneration'. 13 speaker slots for selected posters. Session chair slots. Keynotes, Frances Platt + Volker Haucke. Colworth Medal Ben Ryskeldi-Falcon. Discussion panels + more. SUPER EARLY DEADLINE 1st JUNE 2026 www.eventsforce.net/biochemsoc/f...

The grocery store that I usually go to is about 1.5 miles from my house On Monday, it was like 95 degrees so I took my e-bike rather than my standard bike to turn a ride that I probably would have gotten sweaty from to a ride that was no sweat (even as I wore a backpack) E-bikes are great

I'm wondering how PhD programs are dealing with PhD students who can't match due to funding uncertainty? I've heard of a couple of situations where the student and PI would like to make a match but the PI is waiting on a NOA etc. Are departments bridging or doing something to help make the match?

Hey ASCBers, The deadline for abstracts is suuuper early this year. June 9!

Welp, our -80C Thermo freezer is finally dying after its third compressor. I need to buy a new one. What makes and models are people liking or hating these days? I've not had great luck with Thermo and neither have several labs on my floor. Not sure what to get or to avoid. Help!

We just got approved to hire a teaching professor in Quantitative Methods! This is the *very* rare tenure track teaching position at Berkeley. I'll be chairing the search committee. Official job ad coming later this summer!

📜 Historians of Paris! Huge huge long shot 📜 Is anyone at the Archives Nationales main site at any point in the next few weeks, & willing & able to take a few photographs of documents? Happy to pay for your time, whatever you can spare – pls DM me

How important is the biosketch really? When I review, sometimes it answers some questions I have about contributions of the author to different collaborative studies, or what else they might have on their plate, but I'm curious how others use it and what they see as must include items.

Ah yes. My computer died and my backup computer wasn’t booted recently enough and needs to be reformatted. I must have a grant due soon.

Off to the first of five “Summer of Nanopore” workshops. More than 100 faculty across the U.S. be trained, joining a growing network of educators making genome sequencing a routine part of classroom learning and research experiences. Box 1 of 3; water surveillance mobile lab!

Allosteric Biosensors Unravel GTPase-Effector Feedback by Klaus Hahn and team: www.biorxiv.org/content/10.6...

“Dr. Antaki, a biomedical engineer, had been building an artificial heart for babies and young children, a pump the size of a AA battery, and he was getting close. But with his research grants stopped, Dr. Antaki slowly drained his lab’s rainy day funds, and he was forced to lay off all his staff.”

A new preprint from the lab showing how Atg1 regulates the BLTP Atg2. This study was spearheaded by Sonja Achleitner and Susanna Tulli, involving a fantastic collaboration with @ainaraclaveras.bsky.social and Gerhard Hummer. @maxperutzlabs.ac.at @viennabiocenter.bsky.social @maxplanck.bsky.social