New Article: "A combined biochemical and computational approach provides evidence for membrane remodelling by the structural scaffold of the endocytic TPLATE complex" rdcu.be/eP4fX ... to generate a comprehensive structure of the multisubunit endocytic TPLATE complex.

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

Interested in learning materials to prepare undergraduate students for working with pathogens and pathogen data? I’m hosting a small curriculum development sprint/workshop. Industry/clinical and educators needed. Please share. Apply by November 28, 2025 dnalc.cshl.edu/pdn-2026-wor...

small SOS: My lab is struggling to use Napari to visualize and work with MERFISH images. Can one of you kind experts give my student a few pointers? @mads100tist.bsky.social

Biological Chemistry's position is still taking applications. UM is a great place to be a PI, I'd love to see a new membrane biology or lipids expert join our community. This is open for new and established investigators.

🧪Hey Sciencers: What's the best protein to tag if you want to look at the recycling endosome without disrupting it's function in human cells? @franbottanelli.bsky.social ?

Reposting for the afternoon/early evening scientists

Do you need a cat in your timeline? Happy to oblige. Here is Molly, ready to murder someone because they put the white stuff outside.

From MBoC... Lois Weisman ( @umichnews.bsky.social ) reveals how one protein’s teamwork — or lack of it — could hold clues to treating childhood neurodegenerative disease. 🔗 www.molbiolcell.org/doi/full/10....

Opportunity! Anybody knows of young marine ecologists (within 7 years from earned PhD) that would like to come to Gothenburg, Sweden, for a nationally funded Assistant Professorship? It is highly competitive but well funded. (1) of (3)

Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself! So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)

Finally inoculated the mushrooms for Thanksgiving. I’m sure it’s too late, but maybe for Xmas. Doing pink oysters for the first time.

another sunday, another slew of reco letters for my lovely undergrads. ~ 12 students, each applying to 10-15 schools. you do the math. Why on earth no centralized system like for med school? You do the math for how many faculty hours are 'lost' each fall to this mindless (yet important!) task.

It’s snowing.

A new reporter mouse for visualising Hedgehog/GLI signalling activity This Research Highlight showcases the work from Hannah Schrader Dear, Nicole Franks, Benjamin Allen and colleagues: journals.biologists.com/dev/article/...

2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26 genetics-gsa.org/yeast-2026/

Can somebody get me a PDF of this paper for a student? www.cell.com/current-biol...

In the mid-90s someone I knew very well said something on irc that made our common friends concerned. The friends contacted me. I got worried. I contacted somebody at the university, and that person got help. They did not hurt themselves. Win for rando internet ppl.

Yes they are! Might have been an oversight, but these cultures were established at UNSW in 2019 in @brendanburns999.bsky.social ‘s lab and funded by Australian research grants. The first tomograms that revealed the exciting internal structures were carried out by @debnathghosal.bsky.social

When people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)

🧠 Neurofriends: Who is going to SfN this year? Would anyone like to help me run The Confound Hour on Tuesday night?

When I was submitting a few years ago and having a similar problem the solution I was recommended by the GRFP support was close to this, a printed and scanned copy of the official transcript. Dumb workaround, but functional.

Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...

Thanks to our partner Food Gatherers for their emergency food distribution in the absence of SNAP. The first one is Sat., Nov. 8. No registration required. For more info: https://www.foodgatherers.org/.../FG_Emergency-Food... For all food pantries and meal sites: www.foodgatherers.org/foodresources

Personal good news alert: I’ve been promoted to associate professor and it’s time to update the ol’ bio! Launching my lab at UCSF has been a privilege + I’m so grateful to my team and community here. More exciting science ahead! 🚀

Nobody put the Popemobile Baby in my timeline this year, and dammit, I want to see the Popemobile Baby every year.

Membrane dynamics, repair and disease Keystone symposium this February in Colorado. The real, true, final abstract deadline is tonight so the organizers can start picking the short talks tomorrow! www.keystonesymposia.org/conferences/...

OMFG! It just took me 20 minutes to open powerpoint on my work computer because the search function could only take my to the bleeping app store to try to download it.

Does anyone know of a good textbook/review broadly on erythropoiesis? I'd love to hear your suggestions! 🩸 #hemesky #bloodsky

Very true. For people at Michigan, the campus food pantry is here: mbc.studentlife.umich.edu/how-to-help/ They accept your money, your time, or goods. If you need help, it's open by appointment only and you need an MCard.

So apparently, I took notes last year about my team-taught course on big datasets for me and my co-instructor to look at as we prepped for this year. I totally forgot about it, but he remembered. Wow, it was such a good idea. I totally recommend doing this.

The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor. The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2. www.leadingedgesymposium.org/apply/

Reposting with alt

In honor of the upcoming #WomenInPhysics Day, let's create a thread of amazing women physicists. I'll start with one my favorites, Chien-Shiung Wu, who is best known for conducting the Wu experiment, which proved that parity is not conserved. ⚛️ 🧪 👩‍🔬 🎢

Warning. ⚠️ If you are writing an NSF GRFP, new this year, you need official transcripts to apply. Beware. They will not review applications without official transcripts. ‼️

Ok something weird with Adobe Illustrator. I've embedded an 8-bit image black on white and when I try to shrink it, it gets inverted white on black. Is this some weird AI thing?

And, grant submitted! Included some late-breaking data that really supports our working model. A bit of a nail-biter, we got the 1st replicate on Saturday and then n=2,3,4,5 today.

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/... Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

I'd only dabbled with napari, but needed to use it for a paper we're writing. This is a quick post about getting started: from installation to a folder full of thousands of processed images, with gotchas along the way. quantixed.org/2025/11/04/a...

Yay 'past' me! My co-instructor said that he is reading over the notes I wrote up after our lectures last year to tell 'current' me and him how to improve the lectures. I totally forgot doing it. So glad I did because we teach soon, and I have zero bandwidth to think about the class.

We’re on the cover of @embojournal.org Odin, from Norse mythology, emerges from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 shorturl.at/n7iZE #archaea #evolution #tubulin #cytoskeleton

Molly, I really need to finish this grant. I know it's called a mouse, but you can't attack it time I try to work on a figure.

Professors, some of your students just lost their access to food. This will put a strain on their ability to pay rent and focus in class. They might need to not pay electric to make ends meet. They might be coming to class hungry. Please be aware that the loss of SNAP will impact your students

MMMM daylight savings time one more hour to work on my grant!

What Tyler said. I have trouble reading a lot of fonts, or dark fonts on light backgrounds, or just too small lettering. The way alt-text looks is usually the easiest to see and read.

Reminder that when you post a picture and it doesn't have alt text, it looks naked, and we all point and laugh AT it not with it, then ignore it completely because it's being inappropriate.

Following bc I'm in the same boat. I brought my plant inside bc it has 2 peppers on it that aren't done, but not sure what to do with it once those are done.

Ok, so who has had success overwintering peppers inside in the northern US? What did you do? I've had very little success.

For anyone without the time to bake bread: rice and beans are a great way to get a lot of calories and a complete protein for cheap that still takes some cooking, but not quite as much time.