New paper out! For decades there has been a ‘standard model’ for gamma oscillations. This upends that model - PFC gamma oscillations are not one thing. Rather they dynamically recruit diverse cell type-specific synchrony motifs to implement multiple functions: www.sciencedirect.com/science/arti...

New paper online! How does plasticity at specific synapses drive specific forms of learning? We find that learning extradimensional rule shifts depends on strengthening long-range GABAergic projections from parvalbumin neurons to PFC-MD neurons in the contralateral PFC! www.cell.com/neuron/fullt...

I’m very sad to share that Howard Fields has died. He made seminal discoveries in pain modulation, placebo, and addiction. He was also a wonderful mentor and friend who taught me how to think about the brain and the joy of scientific discovery. www.iasp-pain.org/publications...

Please come by the Sohal lab posters at #SfN2025 to join the discussion about all of our favorite things: cognitive flexibility, gamma oscillations, PFC social encoding, autism mouse models, dopamine, & more!

Two preprints up! The first, led by Aarron Phensy, uses red+green voltage indicators to show that prefrontal gamma oscillations dynamically engage various cell types, creating multiple synchrony configurations, each tied to a distinct aspect of cognitive flexibility: www.biorxiv.org/content/10.1...

(more news) New paper just published! Prefrontal representations of social and emotional information generalize across contexts (even though ensembles for socioemotional + contextual information are highly overlapping): www.nature.com/articles/s41...

New work! Learning is assumed to involve synaptic plasticity, but which specific synapses change to enable higher order cognitive functions? We actually find that cognitive flexibility involves potentiation of long-range GABAergic synapses from prefrontal PV neurons: www.biorxiv.org/content/10.1...

One more post while I'm at it: my 'Meet-the-Clincian-Expert' @neuronline.sfn.org talk, describing my lab's work plus my career path, is now available on demand: neuronline.sfn.org/scientific-r...

Also while I’m posting on BlueSky for the first time, I want to thank to several folks for hosting me last month on a journey where I got to connect with neuroscience in India. First I got to participate in a great symposium on autism and visit Sourav Banerjee’s lab at the NBRC near Delhi. 1/2

New work online! Led by Marc Turner in collaboration with the Rubenstein lab. We studied how disruptions in autism genes alter neural activity to produce abnormal behavior in layer 5 Tbr1 cKO mice, & in the process, found new aspects of PFC socioemotional encoding 1/n www.biorxiv.org/content/10.1...

Excited to share our new paper out now @natureportfolio.bsky.social, where we identified neural signatures of stress susceptibility and resilience in the amygdala-ventral hippocampal network to enable control of anhedonia! <https://www.nature.com/articles/s41586-024-08241-y> Thread below: