We also made a website and python API to run starCAT with several other published gene program catalogs including a myeloid reference from @tymillerlab.bsky.social et al and a hematapoetic stem cell reference from @bloodandtime.bsky.social and Hojun Li

Case CCC/@uhcleveland.bsky.social researcher @tymillerlab.bsky.social targets myeloid cells in brain cancer www.uhhospitals.org/for-clinicia...

Home cooked meals are the best. Grateful to have @vrishab_x's mother visit the lab from Seattle and cook us all authentic South Indian food for lunch today 😋❤️

Celebrating "UH100", the 100th brain tumor we've collected (in ~10 months!) & processed to learn more about these tumors & make patient organoids to test new therapies @uhreinstitute.bsky.social & @caseccc.bsky.social. Thanks to the patients, @staudtmd.bsky.social & Dr. Tiffany Hodges, & my lab!

Congratulations to @terminallycurious.bsky.social, Huang-lab MSTP student @CWRU, on her main thesis project!! Very happy we could help support her great story as our lab's first collaborative project. Turns out mechano-sensors are important in tumor-associated myeloid cells! @caseccc.bsky.social

I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story! jitc.bmj.com/content/13/6...

🚨Registrations now live! Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua Register here: genelayinstitute.org/rtn/

A real privilege to be part of this meeting with so many leaders in the field that I admire. It is an inspiring group of passionate & dedicated physicians/scientists trying to tackle #GBM. Hoping that our collective efforts will lead to effective therapies for these patients. Thanks for the invite!

Our lab @caseccc.bsky.social, CWRU SOM, & University Hospitals is recruiting! We are looking for 2 talented immunotherapy postdocs eager to make an impact for brain tumor patients using cutting edge single-cell & spatial genomics & patient-tissue organoids - join us! Please share positions below:

Honored for our lab to be highlighted in the @caseccc.bsky.social annual report - I can't say enough great things about the environment and support for our new lab. 9 months in and so happy to be @CWRUSOM and @caseccc! A couple pictures in the lab that didn't make the report:

Celebrating two summer fellowships today with ice cream @ Mitchells! Congrats to Kaylie for being awarded the CanSUR fellowship for undergraduates and Medical student Alex Wang the @caseccc.bsky.social Medical Training Award! Both awards will support their work in the lab this summer 🔬

Was great to see friends and colleagues in London as part of the @braintumourcharity.bsky.social annual Scientific Advisory Board meeting! There are exciting things happening in brain tumor research around the world and honored to get to help guide it. Views were pretty good toon

New research uncovers four gene expression “programs” in immune cells that either suppress the immune system or make it more active — and could explain why brain cancer is often resistant to immunotherapy. @danafarbernews.bsky.social @nature.com

Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41...

At #TRCCC @ejohnwherry.bsky.social gave an amazing talk about changing delivery of checkpoint blockade to increase efficacy, then ended with this slide, maybe his most important of the day. Share this information with your friends, family, neighbor!

Proud of my lab members who gave great talks today @ the #TRCCC conference!! Vrishab Kumar & Regan Murphy presented their computational projects this morning, and Shawn Ho & Alex Crane presented myeloid targeting projects this evening. CWRU SOM & @caseccc.bsky.social representing 💯

Annual @sitcancer.bsky.social crew picture at #TRCCC 2025 @immunegirl.bsky.social @ Michelle Williams and Sarah Gitto

The @tymillerlab.bsky.social rolling into #TRCCC 2025 and looking forward to 3 great days learning about the latest in immunotherapy!! #Roadtrip

Excited to be at @UCSF & @UCSFCancer to give the @UcsfPspg seminar today about our work and meet with friends and colleagues! Thanks to @LuRongze for the invite!

The Miller Lab birthday tradition continues at Mitchell's - happy birthday Namita!

I'll say it again, the best part of #SITC2024 is the people @NeuroOncDoc @mwilli323 @SRamakrishna_MD @maraademartino and friends 😁 Thanks for hosting @AkoyaBio!

The best thing about #SITC2024 is the people! @JennGuerriero @immunegirl @sm_blum @ Tom Moran @sitcancer

Excited to be at #SITC2024 - as faculty for the first time! 🤎 badge ribbons, which basically lay out my @sitcancer & @sitcancerECS journey 😀 Recruiting postdocs that are motivated to create effective immunotherapies for brain tumor patients! Reach out! http://Tymillerlab.org

I am honored and humbled to be appointed as the Paul and Betsy Shiverick Professor of Immuno-Oncology. I’m very grateful for generosity and the vision of Paul and Betsy to establish this Professorship &feel incredibly fortunate to be the inaugural chairholder @caseccc & @CWRUSOM!

Let's go Guards!!! @CleGuardians #thisiscleveland

Great to have @CouturierMDPhD visit the lab this week! Looking forward to many continued close collaborations, my friend!

Happy to support the @theABTA this morning in the first annual Cleveland BT5K! Thanks to my co-captain of the @caseccc team, @JustinLathia - proud to have @ClevelandClinic, @CWRUSOM, @UHhospitals researcher & docs team up! Cleveland is the place to be for #braintumor research!

The @TyMillerLab showed out this morning to support @theABTA as part of the @caseccc team! Love that the lab gets engaged supporting brain tumor research funding! Thanks @estrada__edward @Shawn_T_Ho @ReganMurphy20 @Vrishab_x & Meirola! #ClevelandBT5K

That's a wrap on #ReThinkNeuroimmunology 2024! Thanks to @IdoAmitLab and @jonykipnis for an incredible meeting with lots of thought-provoking presentations and conversations. Was honored to be able to present our work and ideas. Until next time!

Great to present our work on understanding and targeting immunosuppressive myeloid cells at #CRUKbrain2024 Also wonderful to get to catch-up with old and new friends! #braintumour

Great ride around Cleveland this morning to support @bikeVeloSano as part of the @caseccc team! Thanks to all the riders and sponsors! (Including @CleGuardians - riding through the stadium was a highlight!) #biketocure #Velosano

Great seeing friends and colleagues at #AARN24! So many connections among the #ABTAResearcher group: - @BradEBernstein @MarioSuva alums @hara_toshiro @WillFlavahan @GilbertRahme - Ohio State @VenereLabOSU Kyle Walsh - NION @d_bayik - Current Cleveland crew (also MANY CLE alums)

Cleveland is the place to be to conduct brain tumor research! The CLE contingent at #AARN24 - a meeting for researchers who have been funded by @theABTA. CLE researchers representing @caseccc @CCLRI & @CWRUSOM made up >10% of attendees! #ABTAResearcher

Welcome, Tempestt, to the @TyMillerLab! Excited to have you join the lab & manage tumor acquisition/ organoid creation! Thanks to the patients for donating their tissue and powering our research! And a huge shout-out to our awesome neurosurgeon partner, Dr. Tiffany Hodges!

We've had a lot of "firsts" in the @TyMillerLab over the last few months! Exciting to start experiments now, but fun to reflect on the last couple months. Big thank you to @Shawn_T_Ho & @estrada__edward for being the 1st to join the lab and building this out with me!

It's been a journey - today, I signed out my first case as an Attending! 14 years after I started medical school🥼 Cool milestone & a moment to reflect, but it's just part of the journey - a really fun, rewarding, challenging, motivating journey #StriveForGreatness (#LeBron fan)

So great to have @CKadoch and family visit us in Cleveland this weekend! Lots of fun family time & there is no better place to hash out our labs' first collaboration than in the sun on a boat (picture for posterity) 😎 #ThisIsCleveland

You know your a scientist Dad when your 4 year old's stuffy for nap time is Stemmy 😎 @miltenyibiotec planting that brand loyalty in early...

Our first lab outing! Excited to have @Shawn_T_Ho start this past week and join @garbanzo_x in the lab! People forget about the North Coast when they think about the coasts 😏 #missingout Great to have @hara_toshiro from UMich join for some fishing! #ThisIsCleveland

Starting our first lab tradition - birthdays are celebrated @MitchellsCleve! Happy birthday to Edward, my first lab hire 🎂

Ending my first week as a PI with a drink with @GryderArt 🍻

I am incredibly excited to announce the opening of the @TyMillerLab at @CWRUSOM and @UHhospitals in Cleveland! My lab will be dedicated to creating effective immunotherapies for brain tumor patients. Learn more at our freshly minted website - https://tymillerlab.org

Keystone afternoon breaks are meant for exploring! 40km round trip bike ride with @JennGuerriero to experience the Gap of Dunloe 🌄 was 💯 #KSMyeloidTargets24

Kicking off the morning at #KSMyeloidTargets24 learning about how to target macrophages in breast cancer, including from @JennGuerriero from @BrighamWomens presenting exciting new data leading to a new clinical trial targeting myeloid cells in breast cancer patients!

So excited to be in beautiful Killarney, Ireland at #KSMyeloidTargets24 with @JennGuerriero @MiriamMerad @MartinGuilliams @jboumelha and many others to hear about the latest in Targeting myeloid cells in cancer!

Very grateful to the @BrainTumourOrg and their fundraisers for supporting our work trying to develop effective immunotherapy strategies for #braintumor patients. Thanks to Kyle for profiling our work and the innovative BTC fellowship program!...

So excited to catch up with @sitcancerECS besties at #TRCCC24! We've decided we are coming to @TRCCC1998 every year ⛷️ @EricaBMD @immunegirl @ Sarah needs to get Twitter

Really honored to be awarded the @bmsnews @sitcancer Cancer Immunotherapy Translational Fellowship at #SITC23! Thank you for supporting my research and career!! @MGHPathology @DFCI_CancerBio Photo cred: @JennGuerriero

I've been looking forward to the Neuroimmunology in Cancer session at #SITC23 all week! @humsav kicking off the session - her talks are always beautiful, visually and scientifically 🌟 Cool new data showing neural innervation driving NSCL cancer growth in both lung and 🧠