1/n: 2nd preprint this week: www.biorxiv.org/content/10.1.... We functionalized a G(13)PCR P2RY8 that keeps germinal center (GC) B cells confined. Taylor LaFlam performed saturation mutagenesis, Aashish Manglik's lab solved the structure, and collaboration with Cyster lab validated variant effects.

New preprint from the lab. Single-cell CITE-seq of 1.5M PBMCs identifies two immunological subtypes of Sjögren’s disease, the second most common autoimmune disease after rheumatoid arthritis: www.biorxiv.org/content/10.1.... 1/n

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Come to UCSF and work with Chris. He’s got some really cool tech that could fundamentally change the way we study and control gene regulation. And oh yeah, this is my first post!