“Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer” A new research from Prof Jochen's lab is now online in CDD ⤵️ www.nature.com/articles/s41... (1/5)

🎗️Sarcoma Awareness Month🎗️ Access our updated collection of Sarcoma-related research papers in: Cell Death & Disease nature.com/subjects/sar... Cell Death Discovery nature.com/subjects/sar... #Sarcoma #SarcomaAwarenessMonth #CancerResearch

“Dysregulation of the TFEB-ATP6V0C axis in microglia exacerbates α-synuclein pathology through impaired lysosomal acidification in Parkinson’s disease” Explore how ATP6V0C overexpression can restore lysosomal function in #ParkinsonDisease ⤵️ www.nature.com/articles/s41...

“Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis” These findings position FAPs as amplifiers of #inflammation in Idiopathic inflammatory myopathies ⤵️ www.nature.com/articles/s41...

“ZFP36L1 and ZFP36L2 cooperatively regulate thymic epithelial cell function to prevent early-onset thymic involution” ZFP36L1:ZFP36L2 #RNAbindingProteins pair: a critical determinant of the TEC #microenvironment’s integrity ⤵️ www.nature.com/articles/s41...

“Efferocytosis enhances macrophage pro-angiogenic functions for bone marrow regeneration” A macrophage-dependent pathway that links #Efferocytosis to #VascularRegeneration ⤵️ www.nature.com/articles/s41...

“Fas acts as a T cell co-stimulatory receptor via both death domain-independent and -dependent mechanisms” Fas is not just about #CellDeath but a key player in #Tcells activation ⤵️ www.nature.com/articles/s41...

“Adipocyte-specific ablation of Gadd45b exacerbates obesity-associated cellular senescence and metabolic disorders via Fgf1b promoter hypermethylation” A mechanistic link between #obesity, #DNAmethylation, and #metabolism ⤵️ www.nature.com/articles/s41...

Mechanism identified in targeted therapy for metastatic #colorectalcancer ⤵️ Researchers at #MedUniVienna have shown that the EGFR receptor influences #immunecells in the #tumour microenvironment – and thus the body’s own defence against #metastaticcolorectalcancer. ⬇️ 📰 @cddpress.bsky.social​

“Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization” Here is why Cat L might be considered a potential candidate target for the treatment of RCC ⤵️ www.nature.com/articles/s41...

“TRIM17 downregulation modulates CRPC progression and enzalutamide resistance by derepressing BCL2 expression via the p53-dependent and p53-independent pathways” A promising therapeutic strategy for ENZ- resistant PCa ⤵️ www.nature.com/articles/s41...

“Identification of tumor-promoting functions of the Homeobox family transcription factor MSX1 in cervical cancer” Learn how MSX1 drives EMT and activates RHO/RAC/CDC42 signalling, and why these findings could open new avenues for targeted therapies ⤵️ www.nature.com/articles/s41...

🎗️Myeloma awareness week🎗️ Explore our updated collection of myeloma-related research papers in Cell Death & Disease: nature.com/subjects/mye... #MyelomaAwarenessWeek #MyelomaResearch #CancerResearch #Oncology #MultipleMyeloma

“Single cells and spatial RNA profiling reveal that inflammatory fibroblasts arise from Edil3 stromal cells in the colon after irradiation” This study offers key insights into the colonic stroma composition ⤵️ www.nature.com/articles/s41...

“A PML1-CCL5-PI3K/MAPK feedback loop governs survival of endocrine-resistant breast cancer cells” This study provides a mechanistic framework for understanding how standard treatments may inadvertently promote the emergence of resistance ⤵️ www.nature.com/articles/s41...

Dive into our June issue here: www.nature.com/cdd/volumes/...

“Cell death–induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation” ACBP/DBI as a systemic biomarker of cell death and organ injury in humans and mice across multiple disease contexts and experimental models ⤵️ www.nature.com/articles/s41...

“When vitamins decide life or death” Explore the multilayered model of vitamin-dependent regulation of cell death in our latest Editorial by Daolin Tang, Gerry Melino, and Guido Kroemer ⤵️ www.nature.com/articles/s41...

“EGFR deletion in myeloid cells reprograms the immunosuppressive landscape of colorectal cancer” A groundbreaking multi-omics study from Prof Sibilia's lab reveals EGFR in specific myeloid cell subsets as a potential new therapeutic target in mCRC ⤵️ www.nature.com/articles/s41...

“Akt-mediated RALY phosphorylation functions as a molecular switch governing c-Myc stability” Researchers uncovered the oncogenic RALY–USP22–c-Myc signalling axis and developed a therapeutic peptide that effectively suppresses tumour growth ⤵️ www.nature.com/articles/s41...

1️⃣ day to go. Join us tomorrow!

“Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release” A mechanistic insight into the intersection between mitochondrial function and innate immune activation ⤵️ www.nature.com/articles/s41...

“GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4” An intriguing oncogenic role for GSDME beyond its canonical pore-forming function in pyroptosis ⤵️ www.nature.com/articles/s41...

“Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence” An interesting link between lipid metabolism in OIS cells and their resistance to ferroptosis and oxidative stress ⤵️ www.nature.com/articles/s41...

“The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway” A comprehensive investigation into the protective role of the E3 ligase Itch in kidney fibrosis ⤵️ www.nature.com/articles/s41...

Death on the Beach: Cell Death & Disease 32nd ECDO Conference 📍Favignana, Italy 🗓️ 16-19 September 2026 📌 Abstract submission deadline: 30 June 2026 More info: ecdo2026.com Preliminary programme: ecdo2026.com/ecdo2026-pro... @ecdoorg.bsky.social #CellDeath #Conference

“Transcription-coupled nucleotide excision repair protects against genomic instability and cell death induced by the liver toxin methyleugenol” Read how TC-NER, rather than GG-NER, is crucial for resolving ME-induced DNA lesions ⤵️ www.nature.com/articles/s41...

“Bon appétit, your phagocyte” New perspective in CDDiscovery on how apoptotic cells undergo a meticulous ‘meal preparation’ process to be optimally suited for consumption by professional and non-professional phagocytes⤵️ www.nature.com/articles/s41...

“CCR7 orchestrates the malignant progression of memory B cells in MYC-overexpressing lymphoma” Learn how CCR7 directs memory-B-cell trafficking from draining LNs to distal LNs and coordinates microenvironmental support to promote progression ⤵️ www.nature.com/articles/s41...

“A neutrophil-intrinsic CKLF1–PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production” The proposed neutrophil-targeted nanotherapeutic approach opens a new avenue for immunometabolic intervention in stroke ⤵️ www.nature.com/articles/s41...

International Cell Death Seminar 📅 Wednesday 3 June 2026 ⏰ 4:30–6:40pm AEST | 8:30–10:40am CEST 💻 Join us on Zoom: latrobe.zoom.us/j/82442848457 @auscelldeathsoc.bsky.social @ecdoorg.bsky.social #CellDeath #BiomedicalResearch #Apoptosis #ResearchSeminar

“Dual targeting of chemoresistance and ferroptosis in gastric cancer: DDR1/VEGFR2 inhibitor K-13 synergizes with docetaxel from preclinical models to phase Ib/II clinical trial” A promising therapeutic strategy for late-stage GC patients ⤵️ www.nature.com/articles/s41...

“Fibroblast-mediated KRAS activation in double-negative prostate cancer” CCL2–FGF–KRAS signalling as a potential therapeutic target for treating AR-independent prostate cancer in late-stage DNPC ⤵️ www.nature.com/articles/s41...

“m6A-mediated CABLES1 translation potentiates tumor radioresistance via facilitating nonhomologous end-joining repair” Discover how CABLES1 inhibition may synergize with existing cancer therapies ⤵️ www.nature.com/articles/s41...

“USP4 modulates ZBP1 ubiquitination to regulate microglial PANoptosis and functional outcomes following traumatic brain injury” These findings identify USP4 as a promising therapeutic target for TBI treatment ⤵️ www.nature.com/articles/s41...

Dive into our May issue: www.nature.com/cdd/volumes/...

“GET3 regulates apoptosis via tail-anchoring of MCL1” This study provides direct experimental evidence that the GET3 pathway is involved in regulating the anti-apoptotic functions of MCL1 ⤵️ www.nature.com/articles/s41...

“Transcriptional and ubiquitinative suppression of macrophage CST3 disrupts colonic homeostasis through defective efferocytosis” This study proposes a multimodal model of macrophage-epithelial crosstalk mediated by macrophage-specific CST3 ⤵️ www.nature.com/articles/s41...

“The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiation” LIN28A’s role in neural development and differentiation extends beyond microRNA biogenesis and mRNA translation ⤵️ www.nature.com/articles/s41...

“Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway” Explore how TFP was repurposed to selectively induce MC apoptosis⤵️ www.nature.com/articles/s41...

“TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer” Learn more about this tumor-suppressive pathway to improve strategies for mCRC prevention and treatment ⤵️ www.nature.com/articles/s41...

May is Melanoma and Skin Cancer Awareness Month Perfect timing to explore these updated collections of melanoma-related research papers in CDDIS: www.nature.com/subjects/mel... and CDDiscovery: www.nature.com/subjects/mel... #MelanomaAwarenessMonth #SkinCancerAwareness #EarlyDetection

“Nucleoporin TPR integrates MAPK signaling with mitogen-induced transcriptional programs” This study positions the nuclear pore complex as a dynamic signaling hub that integrates extracellular oncogenic cues with nuclear transcriptional output ⤵️ www.nature.com/articles/s41...

Dive into our April issue here: www.nature.com/cdd/volumes/...

“NINJ1 ubiquitination by TRIM72 protects against plasma membrane rupture and AKI-CKD progression” The TRIM72-NINJ1-HMGB1 axis as a central molecular checkpoint in the transition from acute kidney injury to chronic kidney disease ⤵️ www.nature.com/articles/s41...

“Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via m6A-mediated IL-6R stabilization in pulmonary vascular remodeling” Learn more about the molecular mechanisms downstream of IL-6 in pulmonary vascular remodeling www.nature.com/articles/s41...

“Pseudo-senescence induced by palbociclib does not sensitise pleural mesothelioma cells to combinations with senolytics” Understanding the type of therapy-induced senescence is essential for predicting the success of senolytic drug combinations ⤵️ www.nature.com/articles/s41...

“Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology” This review dissects 18 tRNA-modifying enzymes and their role in regulating codon-biased translation in cancer ⤵️ www.nature.com/articles/s41...

“Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis” Study from Prof. Sette’s lab identifies potential markers for MS-related CI ⤵️ www.nature.com/articles/s41...

“Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription” Explore this emerging link between mitochondrial dynamics and tumor immune evasion ⤵️ www.nature.com/articles/s41...