“A neutrophil-intrinsic CKLF1–PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production” The proposed neutrophil-targeted nanotherapeutic approach opens a new avenue for immunometabolic intervention in stroke ⤵️ www.nature.com/articles/s41...

International Cell Death Seminar 📅 Wednesday 3 June 2026 ⏰ 4:30–6:40pm AEST | 8:30–10:40am CEST 💻 Join us on Zoom: latrobe.zoom.us/j/82442848457 @auscelldeathsoc.bsky.social @ecdoorg.bsky.social #CellDeath #BiomedicalResearch #Apoptosis #ResearchSeminar

“Dual targeting of chemoresistance and ferroptosis in gastric cancer: DDR1/VEGFR2 inhibitor K-13 synergizes with docetaxel from preclinical models to phase Ib/II clinical trial” A promising therapeutic strategy for late-stage GC patients ⤵️ www.nature.com/articles/s41...

“Fibroblast-mediated KRAS activation in double-negative prostate cancer” CCL2–FGF–KRAS signalling as a potential therapeutic target for treating AR-independent prostate cancer in late-stage DNPC ⤵️ www.nature.com/articles/s41...

“m6A-mediated CABLES1 translation potentiates tumor radioresistance via facilitating nonhomologous end-joining repair” Discover how CABLES1 inhibition may synergize with existing cancer therapies ⤵️ www.nature.com/articles/s41...

“USP4 modulates ZBP1 ubiquitination to regulate microglial PANoptosis and functional outcomes following traumatic brain injury” These findings identify USP4 as a promising therapeutic target for TBI treatment ⤵️ www.nature.com/articles/s41...

Dive into our May issue: www.nature.com/cdd/volumes/...

“GET3 regulates apoptosis via tail-anchoring of MCL1” This study provides direct experimental evidence that the GET3 pathway is involved in regulating the anti-apoptotic functions of MCL1 ⤵️ www.nature.com/articles/s41...

“Transcriptional and ubiquitinative suppression of macrophage CST3 disrupts colonic homeostasis through defective efferocytosis” This study proposes a multimodal model of macrophage-epithelial crosstalk mediated by macrophage-specific CST3 ⤵️ www.nature.com/articles/s41...

“The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiation” LIN28A’s role in neural development and differentiation extends beyond microRNA biogenesis and mRNA translation ⤵️ www.nature.com/articles/s41...

“Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway” Explore how TFP was repurposed to selectively induce MC apoptosis⤵️ www.nature.com/articles/s41...

“TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer” Learn more about this tumor-suppressive pathway to improve strategies for mCRC prevention and treatment ⤵️ www.nature.com/articles/s41...

May is Melanoma and Skin Cancer Awareness Month Perfect timing to explore these updated collections of melanoma-related research papers in CDDIS: www.nature.com/subjects/mel... and CDDiscovery: www.nature.com/subjects/mel... #MelanomaAwarenessMonth #SkinCancerAwareness #EarlyDetection

“Nucleoporin TPR integrates MAPK signaling with mitogen-induced transcriptional programs” This study positions the nuclear pore complex as a dynamic signaling hub that integrates extracellular oncogenic cues with nuclear transcriptional output ⤵️ www.nature.com/articles/s41...

Dive into our April issue here: www.nature.com/cdd/volumes/...

“NINJ1 ubiquitination by TRIM72 protects against plasma membrane rupture and AKI-CKD progression” The TRIM72-NINJ1-HMGB1 axis as a central molecular checkpoint in the transition from acute kidney injury to chronic kidney disease ⤵️ www.nature.com/articles/s41...

“Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via m6A-mediated IL-6R stabilization in pulmonary vascular remodeling” Learn more about the molecular mechanisms downstream of IL-6 in pulmonary vascular remodeling www.nature.com/articles/s41...

“Pseudo-senescence induced by palbociclib does not sensitise pleural mesothelioma cells to combinations with senolytics” Understanding the type of therapy-induced senescence is essential for predicting the success of senolytic drug combinations ⤵️ www.nature.com/articles/s41...

“Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology” This review dissects 18 tRNA-modifying enzymes and their role in regulating codon-biased translation in cancer ⤵️ www.nature.com/articles/s41...

“Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis” Study from Prof. Sette’s lab identifies potential markers for MS-related CI ⤵️ www.nature.com/articles/s41...

“Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription” Explore this emerging link between mitochondrial dynamics and tumor immune evasion ⤵️ www.nature.com/articles/s41...

“FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis” Read more about FAAH as a prognostic biomarker and a potential therapeutic target for lipid metabolism-related malignancies ⤵️ www.nature.com/articles/s41...

"Targeting CAFs-derived PCSK6 inhibits redistribution of PD-L1 and restores response of CD8+T cells against colorectal cancer" Read more about this specific subtype of CAFs involved in immune suppression and CRC progression ⤵️ www.nature.com/articles/s41...

“p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials” A comprehensive overview of p63 and its core functions in skin biology: www.nature.com/articles/s41...

“HECT ubiquitin ligases as regulators of inflammatory signalling” In this timely and well-organised review, Prof. Sharad Kumar and colleagues provide insights into how ubiquitin signalling shapes inflammation and disease. ⤵️ www.nature.com/articles/s41...

“Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses” Find out more about this novel mechanistic link between the Shoc2 scaffold, mitochondrial function, mTOR signalling, and innate immune response ⤵️ www.nature.com/articles/s41...

New paper from the lab out in Cell Death & Disease @cddpress.bsky.social @cbm-csic-uam.bsky.social "Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis.” #p53 #Drosophila Thread 1/9👇👇👇

“The cGAS-STING pathway in cancer: friend or foe” Check out this review in CDDIS: www.nature.com/articles/s41...

“PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion” Read this fascinating work highlighting how the ATM-PINK1-STUB1-ABCD3-SQSTM1 axis modulates pexophagy and peroxisomal quality control ⤵️ www.nature.com/articles/s41...

"STING is the scaffold protein for stress granule pre-condensation at the ER" Read more about this novel and non-canonical function of STING here: www.nature.com/articles/s41...

Novel insights for GBA1-PD treatment strategies: “GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration” ⤵️ nature.com/articles/s41...

Join us at the 32nd ECDO Conference “Death on the Beach: Cell Death & Disease” 🌊 📍 Favignana, Italy 📅 Sept 16–19, 2026 3 Nobel Laurates, 4 days of science, networking & Mediterranean vibes 🇮🇹 Don’t miss it! #ECDO2026 #CellDeath #ScienceSA ecdo2026.com

"Extracellular GPX4 functions as an immunosuppressive DAMP in ferroptosis” Read this comment on CDD ⤵️ www.nature.com/articles/s41...

Dive into our March issue here: www.nature.com/cdd/volumes/...

“Targeting the PSMD14-BCKDK pathway overcomes immune suppression and enhances CAR-NK infiltration in glioblastoma” ⤵️ www.nature.com/articles/s41...

“DR5/WDR12 balances p65 stability promoting sunitinib resistance in renal cell carcinoma” ⤵️ www.nature.com/articles/s41...

“Znhit3 regulates p53/p21 signaling and governs cerebellar granule cell development” Online in CDD: www.nature.com/articles/s41...

“Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer” ⤵️ www.nature.com/articles/s41...

“Caspase-8-mediated CYLD cleavage boosts LPS-induced endotoxic shock” by Prof Haibing Zhang and colleagues ⤵️ www.nature.com/articles/s41... And do not miss its Editorial, written by Prof Douglas R. Green “Caspase-8 comes in from the CYLD” ⤵️ www.nature.com/articles/s41...

"Targeting the C/EBPβ-PRAME-EZH2 complex modulates the Netrin-4/AKT axis to inhibit renal cancer tumorigenesis and metastasis" ⤵️ www.nature.com/articles/s41... Along with its Editorial, written by Prof. Salomoni ⤵️ www.nature.com/articles/s41...

“Modulation of immune cells and metabolic reprogramming in efferocytosis” Check out this review on CDDIS: www.nature.com/articles/s41...

“Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation“ by Gang Yin and colleagues Now on CDD: www.nature.com/articles/s41...

“Amyloid-β and Tau in Alzheimer’s disease: pathogenesis, mechanisms, and interplay” Find this timely review by Dr Domenico Praticò et al. here: www.nature.com/articles/s41...

“Gut-derived hyodeoxycholate reprograms the spleen–eye immunometabolic axis to suppress autoimmune uveitis” Check out our latest work on CDD, the result of a great collaboration between Wei Jia, Xiaolu Yang, Aiping Lu, and Gerry Melino. www.nature.com/articles/s41...

“Phagocytosis of necroptotic cells optimizes type 1 conventional dendritic cells for induction of a cytotoxic T-cell response” from Dr. Jannie Borst’s lab Read here: www.nature.com/articles/s41...

“HIF2α-induced lysyl oxidase safeguards successful pregnancy by remodelling collagens at the feto-maternal interface” Read this new paper by Yasushi Hirota et al. now on CDDIS: www.nature.com/articles/s41...

“Functional genomic screens uncover FERMT2 as a critical regulator of YAP/TAZ-driven tumorigenicity” Check out this new paper by Campaner et al. www.nature.com/articles/s41...

A concise overview of recent advances in understanding the diverse roles of RCD in MS ⤵️ Cell death in multiple sclerosis here: rdcu.be/e7AzH

“The TP53 gene contains a diversity box that makes it more than a tumor suppressor” Find this informative and well-constructed review here: rdcu.be/e7boq

In case you missed it, our 2025 review on the BCL-2 protein family summarises the field from discovery to drug development The BCL-2 protein family: from discovery to drug development Read here: rdcu.be/e6MVA