Hii! Last week Quanta published a project I've been working on all year — a special issue about climate science, or what research into climate change is revealing about how our planet works www.quantamagazine.org/how-we-came-...

Targeting tumor-associated carbohydrate antigens via “velcro-like” binding of lectins allows immunosuppression-resistant pan-cancer killing while ignoring normal tissues @cellcellpress.bsky.social @ucirvine.bsky.social www.cell.com/cell/fulltex...

1/ I’m excited to share recent work on inferring cell-cell interactions using attention by @justjhong.bsky.social and me, supervised by @elhamazizi.bsky.social . Open the thread 🧵 for a brief overview of our method. bioRxiv link: www.biorxiv.org/content/10.1....

I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA 10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)

Huntington's disease has been successfully treated for the first time, doctors tell BBC

Cross-species👤🐷🐭 analysis of elastic or coronary artery mesenchymal cells in #Atherosclerosis 75% mesenchymal cells shared as Contractile (ACTA2 CNN1 FLNA)- Intermediate (marked by species-specific genes)-Dedifferentiated (LUM DCN NDUFA4L2) #SmoothMuscleCell states www.biorxiv.org/content/10.1...

We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics. We applied this workflow to map precancerous lesions of the fallopian tubes. More here: www.biorxiv.org/content/10.1...

Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance. The regulation of most proteins is dominated by different regulatory mechanisms across cell types. Gratifyingly, this complex regulation defines simple rules ⬇️ www.biorxiv.org/content/10.1...

Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org 🧪 plos.io/4lQMeNu

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

"...Evaluation methods actively encouraged the problem. Analysis of popular benchmarks, including GPQA, MMLU-Pro, and SWE-bench, found 9 out of 10 major evaluations ... penalized “I don’t know” responses while rewarding incorrect but confident answers." www.computerworld.com/article/4059...

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

A post about Emmy Noether, one of the most influential mathematical physicists of the 20th century, who rarely gets the recognition she deserves. blog.genesmindsmachines.com/p/how-do-bic...

1🧵 Excited to share my first PhD paper, published in @dev-journal.bsky.social What if fish gills —often overlook —hold secrets about development, patterning, and function? We uncovered how early patterning shapes adult gill architecture. journals.biologists.com/dev/article/... #DevBio #Zebrafish

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics. Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri! www.biorxiv.org/content/10.1...

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an we understand biology from "infinite" amounts of perturbation data ? - Only if we measure the relevant molecules. Perturbations and data scale 𝐜𝐚𝐧𝐧𝐨𝐭 compensate for missing the relevant molecules. 🧵

Really insightful post from Julie Tibshirani (spotted in LinkedIn, can't find on Bsky) reflecting on #rstats 's unique governance structure and what can be learned for other languages jtibs.substack.com/p/if-all-the...

This is extremely cool!!

Next up will be a couple of days in the @oxfordmathematics.bsky.social department at @ox.ac.uk to visit the amazing Helen Byrne (and hopefully Philip Maini!). Excited to share some of our work in a seminar talk the first day and see about possible collaborations! www.cell.com/cell/fulltex...

Let's talk about Petri dishes & specifically about the people in Robert Koch's lab who developed them. Koch developed a method of pouring liquid broth into glass trays, streaking them with sterile loops inoculated with bacteria, then covering them with a bell jar. 🧪

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

This is my impression too. The poorer our critical thinking skills, the less opposition there can be to fascist and autocratic power.

Our latest manuscript is out, and this one tackles the problem of cellular aging in the retina, using comparative multiomic analysis of zebrafish, mouse, and humans. What led us to work on aging after studying development and regeneration? Explainer follows./1 www.biorxiv.org/content/10.1...

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

Huge thanks to all co-authors and the inimitable @jbuenrostro.bsky.social for supporting this new direction - I got to think about evolution, engineering, chromatin biophysics, and modeling during the course of this project. For more, check out the preprint: www.biorxiv.org/content/10.1... 8/9

Systematic attribution of heatwaves to the emissions of carbon majors Through their emissions, every carbon major contributes (Gazprom, Shell, BP, ExxonMobil, etc...) to climate change and thus to the heatwaves cc @valmasdel.bsky.social www.nature.com/articles/s41...

Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

Statistical inference for data science by Brian Caffo #RStats https://bigbookofr.com/chapters/statistics.html#statistical-inference-for-data-science

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

What‘s really sickening is that publishers are raking in money by selling our work at zero cost to themselves, yet still demanding we and our institutions pay to read other scientists work.

The intricacies of a single cell and the vastness of the universe humble me. The biggest black hole ever discovered: three-alpha.space/p/the-bigge...

new out in Nature www.nature.com/articles/d41...

Making a heatmap is an essential skill for a bioinformatician. But you probably do not understand heatmap. 7 reading resources to understand heatmap! 🧵

A shout out for @nrennie.bsky.social fab book on data viz! nrennie.rbind.io/art-of-viz/

Man these folks are all just so skilled www.youtube.com/watch?v=CGJr...

The new NIH grant review format and the iron law of unintended consequences drugmonkey.wordpress.com/2025/08/27/t...

I am thrilled to share the main result of our work at @nordenlab.bsky.social with @liormoneta.bsky.social and @carldmodes.bsky.social . We bridged DevBiology + theoretical physics to understand how the eye becomes round #morphogenesis #devbio #biophysics #zebrafish www.biorxiv.org/content/10.1...

"Single cell RNA seq reveals the pro-regenerative phenotype of thrombospondin-2 deficient dermal fibroblasts" www.nature.com/articles/s41... Amazing work from Huang et al!

📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells Guest Editors: Alex Hughes and Rashmi Priya 📅 Deadline: 1 March 2026 journals.biologists.com/dev/pages/ex... #DevBio

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

EBV induces CNS homing of B cells attracting inflammatory T cells. www.nature.com/articles/s41...

9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American." It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...

at their core, trans rights, abortion rights, and vaccine rights are actually all the same issue: they’re all about bodily autonomy, and the willingness to concede any of them puts the others at risk.

Tae Heung “Will” Kim, a doctoral student at Texas A&M University and longtime US permanent resident, has been in ICE detention for OVER one month. The AAUP stands with the Texas AAUP state conference in demanding Mr. Kim’s release. www.aaup.org/news/aaup-st...

#RNAbiology #RNAlocalization #LocalizedTransaltion www.cell.com/cell/fulltex...

Heterotypic intercellular adhesion tunes efficiency of cell-on-cell migration https://www.biorxiv.org/content/10.1101/2025.08.29.673192v1

Sometimes we’re unsatisfied with a thing we made because when it only existed in our head, we saw all the things it could have been and when it’s done we know all the things that it isn’t, but we can’t see the way it expands into a million new things when someone else unpacks it in their head. 🖊️🦑