🧩 New insights into the #gut–#brain axis: 🦠L-lysine boosts barrier function & eases anxiety via tryptophan metabolism 😟H. biformis strengthens the barrier but worsens #anxiety 💻Multi-omics reveal lysine degradation as a key mechanism 🔗 doi.org/10.1002/imo2... #microbiome #Bioinformatics

🚀 317 R scripts for biomedical research, no coding barrier ⏱️ Standardized design saves time ✅ Verified, annotated, reproducible 🧬 Covers #scRNA-seq, spatial #transcriptomics, #ML & more 🔗 doi.org/10.1002/imm3... #Bioinformatics

🫀🦠 Gut–heart axis in #CAD: distinct microbial & metabolic shifts across normal, sCAD & ACS; ACS signatures partly reversible. Multi-omics #ML outperforms clinical risk factors in stratifying CAD subtypes. 🔗 onlinelibrary.wiley.com/doi/10.1002/... #microbiome

🦠 #Lactobacillus johnsonii-FM1 fights colorectal #cancer: 🌱 Restoring gut diversity & barrier integrity 🔬 Producing VCA via vanillin dehydrogenase ❌ VCA blocks #CRC cell growth & Wnt/β-catenin signaling 👉 A gut microbe–metabolite axis for anti-CRC therapy. 🔗 onlinelibrary.wiley.com/doi/10.1002/...

🚀 #fastp: ultra-fast, full-featured & user-friendly #FASTQ preprocessing tool! ☁️ Cloud-friendly, minimal resources, web-based reports 📊 v1.0 brings enhanced HTML reporting & parallel batch processing onlinelibrary.wiley.com/doi/10.1002/... #Bioinformatics #NGS #sequencing

🌍 New study on hypervirulent #Klebsiella pneumoniae (CC23-K1): 🔹 Geographic distance drives global spread patterns 🔹 >130 gain/loss events show unstable carbapenem resistance 🔹 KPC/NDM (Asia) conflict with #virulence, OXA-48 (Europe) better preserves it 🔗 onlinelibrary.wiley.com/doi/10.1002/...

🚀SCTP, a deep fusion model of #scRNA-seq, spatial & phenotypic #transcriptomics, quantifies #CRC malignancy with high accuracy. ✅ Detects subregions & warning genes missed by pathology ✅ SCTP-CRC generalizes to liver mets, validates #MUC2 biomarker 🔗 onlinelibrary.wiley.com/doi/10.1002/... #cancer

🌐 Meet GISDD — an #AI-powered #Bioinformatics platform for fast dengue virus (DENV) genotyping & tracing. Upload your sequence ➡️ get instant genotype, origin & risk insights. Supporting global DENV surveillance & collaboration. #DENV #Genomics #PublicHealth onlinelibrary.wiley.com/doi/10.1002/...

🚀 PSOSP predicts #prophage induction! From 49,333 genomes, we uncovered 11,806 SiPs, showing unique genomic/host traits and hinting at SiP–SdP interconversion. onlinelibrary.wiley.com/doi/10.1002/... Available: vee-lab.sjtu.edu.cn/PSOSP/ #Bioinformatics #microbiome

Soil is the most diverse microbial ecosystem, which makes microbiome studies with shotgun sequencing extremely tricky! In our last paper @imetascience.bsky.social, we show that co-assembly increases gene and genome recovery tinyurl.com/59t4z8fh #soilmicrobiome #metagenomics

#Tumor Electrophysiology in Precision Tumor Therapy #iMetaMed onlinelibrary.wiley.com/doi/10.1002/... #CancerTherapy #CancerResearch

Unveiling Origin Pitfalls in #Metagenomic Surveillance for Emerging Infectious Diseases: #Parvoviruses as a Model #iMetaMed onlinelibrary.wiley.com/doi/10.1002/... #mNGS #NGS #chatGPT #AI

🎉 Milestone for #iMetaMed! We’ve just published our first paper, FastUKB 🚀 iMetaMed advances research in multi-#omics, big data, #AI & precision medicine in #healthcare. More here: onlinelibrary.wiley.com/journal/3066...

Discovery of a novel tetrapeptide as #glucose homeostasis modulator with bifunctionalities of targeting DPP‐IV and #microbiota onlinelibrary.wiley.com/doi/10.1002/... #Akkermansia #AI #microbiome

RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling onlinelibrary.wiley.com/doi/10.1002/... #CancerResearch #CancerTherapy #HCC #ferroptosis #nanotech

Functional #metagenomics reveals novel antibiotic resistomes in polar soils onlinelibrary.wiley.com/doi/10.1002/... #antibiotics #ARG #microbiome

Early #matrine intervention of gut #microbiota for type 2 diabetes prevention #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #T2D #microbiome

A portable #device for probiotic counting and viability assessment based on #microfluidic chip and image recognition #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #probiotics #biosensor #microbiome

RTTAP: Empowering metatranscriptomic data analysis with a read‐based total‐infectome taxonomic solution #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #Bioinformatics #taxonomy #diversity

Distinctive metabolic disturbances associated with redox homeostasis, nervous and hormonal functions during gut microbial enrichment upon polystyrene microplastic exposure #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #Microplastics #microbiome #metabolomics #RedoxBiology #Environment

Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome onlinelibrary.wiley.com/doi/10.1002/... #galactosidase #PCOS #microbiome #DHPAA

🧪Struggling to induce #prophage? 🧬 Meet PSOSP, a tool to predict prophage induction mode! 🚀Distinguishes SOS-dependent vs independent prophages. 🖥️Available on web server: vee-lab.sjtu.edu.cn/PSOSP and Github: github.com/mujiezhang/P... #Bioinformatics #phage #viruse #microbiome #GutHealth

#Multiomics integration unravels genotype‐microbiome interactions shaping the conjunctival transcriptome #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #transcriptome #MachineLearning #microbiome #Bioinformatics

Harnessing gut #microbiota for #longevity: Insights into mechanisms and genetic manipulation #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #microbiome #aging #SCFA

Global meta‐analysis reveals the drivers of gut #microbiome variation across vertebrates #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #antibiotics #diet

#Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate #diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 #immune axis onlinelibrary.wiley.com/doi/10.1002/... #microbiome

Integrated #omics revealed the altered colonic microenvironment after inhibition of peripheral serotonin synthesis by #LP533401 #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #serotonin #metabolomics #microbiome #vitamin

Saliva MicroAge: A salivary #microbiome based machine learning model for noninvasive #aging assessment and health state prediction #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #MachineLearning #OralHealth

Emerging role of gut #microbiota extracellular vesicle in #neurodegenerative disorders and insights on their therapeutic management #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #inflammation #microbiome #GutHealth

Genome #assembly and genomic architecture of a prominent cold‐resistant rapeseed germplasm #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #Bioinformatics #genome #phylogenetics #methylation

HiFi based metagenomic assembly strategy provides accuracy near isolated #genome resolution in MAG #assembly onlinelibrary.wiley.com/doi/10.1002/... #iMetaOmics #microbiome #Bioinformatics #MAG

Electroacupuncture reshapes the microbial co‐occurrence networks related to the behavioral and psychological symptoms of dementia in #Alzheimer's disease #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #microbiome

Commentary on LRAs targeting NF‐κB with #epigenetic and mutational impacts on #HIV latency #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #methylation #epigenetics

Multi‐omics analysis of #gut‐organ axes reveals the high‐altitude adaptation in Tibetan #chicken onlinelibrary.wiley.com/doi/10.1002/... #iMetaOmics #poultry #GutHealth #microbiome

TBCancer: A #database for exploring characteristics and functions of tissue‐biased genes in #cancer #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #scRNA #TME #immun

When the #microbiome meets One Health principle: Leading to the Holy Grail of biology and contributing to overall well‐being and social #sustainability #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #OneHealth #ecology

OUTPOST: A comprehensive analysis software for whole‐metagenome shotgun sequencing incorporating group stratification #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #metagenome #microbiome #Bioinformatics

SynCom‐mediated #herbicide degradation activates microbial #carbon metabolism in soils onlinelibrary.wiley.com/doi/10.1002/... #microbiome #SoilHealth

A gut #microbiota‐bile acid axis inhibits the infection of an emerging #coronavirus by targeting its cellular receptor aminopeptidase N #microbiome onlinelibrary.wiley.com/doi/10.1002/...

#Arabidopsis multiomics reveals the role of #autophagy in root #microbiome assembly #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...

#Probiotics restore enteric HDL3 secretion and improve prognosis in patients with end‐stage renal disease onlinelibrary.wiley.com/doi/10.1002/... #ESRD #kidneyhealth

PMAT2: An efficient graphical #assembly toolkit for comprehensive organellar genomes, available at onlinelibrary.wiley.com/doi/10.1002/... github.com/aiPGAB/PMAT2 #mitochondria #chloroplast #Bioinformatics

Novel insights into #immunopathogenesis and crucial #biomarkers between primary open‐angle #glaucoma and systemic lupus erythematosus onlinelibrary.wiley.com/doi/10.1002/... #scRNA #SLE #PPI #MachineLearning

#Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #FMT #metabolome

Culture dependent and independent approaches reveal the role of specific #bacteria in human #skin #aging #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #microbiome

Neoadjuvant #immunotherapy driven #bladder preservation for muscle invasive bladder #cancer onlinelibrary.wiley.com/doi/10.1002/... #CancerResearch

BioMGCore: A toolkit for detection of biological metabolites in microbiome #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/... #Bioinformatics #microbiome #metabolism

scRiskCell: A single‐cell framework for quantifying #islet risk cells and their adaptive dynamics in type 2 diabetes onlinelibrary.wiley.com/doi/10.1002/... #scRNA #T2D #Bioinformatics

Gut #microbiota and #tuberculosis onlinelibrary.wiley.com/doi/10.1002/... #microbiome #AI #Mycobacterium

#Macrophage‐derived reactive oxygen species promote #Salmonella aggresome formation contributing to bacterial antibiotic persistence onlinelibrary.wiley.com/doi/10.1002/... #antibiotics #ROS