🔥Latest Article! Single-cell analysis uncovers smooth muscle cell subtype switching as a key driver of fibrosis, inflammation, and vascular disruption in aortic dissection. #AorticDissection #SingleCell #Vascular #Fibrosis onlinelibrary.wiley.com/doi/10.1002/...

🧬Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells ⚙️ This attention-based model traces rare CTCs directly from blood without enrichment, supporting early detection and anti-metastatic strategies. onlinelibrary.wiley.com/doi/10.1002/...

The DGKα/PA axis drives immune evasion by activating NF-κB and upregulating PD-L1 in tumors. ⚙️ Inhibiting DGKα reduces PD-L1, enhances CTL infiltration, and improves ICI efficacy, with plasma PA as a potential biomarker in gastrointestinal cancers. onlinelibrary.wiley.com/doi/10.1002/...

💪Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming ⚙️ Enrichment of Lactobacillus johnsonii and secondary bile acids activates PAX7/NMRK2 pathways, promoting muscle regeneration. onlinelibrary.wiley.com/doi/10.1002/...

🧐Microbial metabolites in tumor epigenetic regulation The gut microbiome reshapes tumor epigenetics via metabolite signaling.Bile acids and tryptophan-derived ligands regulate HDAC/DNMT/AhR pathways, altering chromatin states and tumor behavior. onlinelibrary.wiley.com/doi/10.1002/...

Spatial multi-omics identifies a NOTCH3-mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma Fibrosis-driven immune exclusion in HCC is linked to endothelial–CAF crosstalk… onlinelibrary.wiley.com/doi/10.1002/...

👏A large-scale single-cell transcriptomic atlas indicates the immune panorama of influenza A infection We generated a large-scale single-cell transcriptomic atlas from peripheral blood, profiling more than 612,010 cells from 97 individuals. #HostResponse onlinelibrary.wiley.com/doi/10.1002/...

Two stable gut microbiome guilds predict liver tumor class and treatment responses ⚙️ Functionally opposing microbial guilds highlight an ecological basis for tumor progression and clinical outcomes. #Hepatocellular onlinelibrary.wiley.com/doi/10.1002/...

Sangerbox 2: Enhanced functionalities and update for a comprehensive clinical bioinformatics data analysis platform onlinelibrary.wiley.com/doi/10.1002/...

STAGER checklist: Standardized testing and assessment guidelines for evaluating generative artificial intelligence reliability onlinelibrary.wiley.com/doi/10.1002/...

USEARCH 12: Open-source software for sequencing analysis in bioinformatics and microbiome onlinelibrary.wiley.com/doi/10.1002/...

iNAP 2.0: Harnessing metabolic complementarity in microbial network analysis onlinelibrary.wiley.com/doi/10.1002/...

Duck gut metagenome reveals the microbiome signatures linked to intestinal regional, temporal development, and rearing condition onlinelibrary.wiley.com/doi/10.1002/...

Specificity landscapes of 40 R2R3-MYBs reveal how paralogs target different cis-elements by homodimeric binding onlinelibrary.wiley.com/doi/10.1002/...

Two telomere-to-telomere pig genome assemblies and pan-genome analyses provide insights into genomic structural landscape and genetic adaptations onlinelibrary.wiley.com/doi/10.1002/...

The microbiome in cancer onlinelibrary.wiley.com/doi/10.1002/...

HLF and PPARα axis regulates metabolic-associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota onlinelibrary.wiley.com/doi/10.1002/...

Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell differentiation onlinelibrary.wiley.com/doi/10.1002/...

Age-specific reference intervals for plasma amino acids and their associations with nutrient intake in the Chinese pediatric population onlinelibrary.wiley.com/doi/10.1002/...

RepliChrom: Interpretable machine learning predicts cancer-associated enhancer-promoter interactions using DNA replication timing onlinelibrary.wiley.com/doi/10.1002/...

scRiskCell: A single-cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes onlinelibrary.wiley.com/doi/10.1002/...

Climate factors drive the local adaptation of Old World cattle onlinelibrary.wiley.com/doi/10.1002/...

🌱 A clickable probe-based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts onlinelibrary.wiley.com/doi/10.1002/...

🤔A microbiota-targeted peptide shows promise for protecting the intestine from radiation injury. Inhibition of ferroptosis by microbiota-derived lithocholic acid underlies the intestinal radioprotection of a host defensin-derived oligopeptide. onlinelibrary.wiley.com/doi/10.1002/...

Metabolic reprogramming of intestinal epithelial cells offers a new strategy for IBD–CDI treatment 💊 An oral proton-reprogrammed nanomedicine to break the inflammatory bowel disease-Clostridium difficile infection vicious cycle @WileyHealth onlinelibrary.wiley.com/doi/10.1002/...

🌿Curcuminoids amplify host innate antiviral immunity via the CRYAB-RBM26 axis in viral infection #VirusDefense #Curcuminoids #ScientificBreakthrough onlinelibrary.wiley.com/doi/10.1002/...

🚀 New breakthrough in cancer detection! Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells #CancerResearch #LiquidBiopsy #PanCTC #CancerDetection #AIinMedicine onlinelibrary.wiley.com/doi/10.1002/...

👏 Targeting ferroptosis in NASH 🧐 A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitise. #NASH #Ferroptosis #LiverDisease #Metabolism onlinelibrary.wiley.com/doi/10.1002/...

BIOME cohort: Multi-system microbiome dynamics and clinical outcomes in massive burn injury patients 🔥 A cohort to map microbiome dysbiosis after massive burn injury. onlinelibrary.wiley.com/doi/10.1002/...

EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research onlinelibrary.wiley.com/doi/10.1002/...

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis. onlinelibrary.wiley.com/doi/10.1002/...

⛰️ Gut microbiome–host metabolism supports high-altitude adaptation in ruminants. The role of the gut microbiome in the regulation of high-altitude adaptation. onlinelibrary.wiley.com/doi/10.1002/...

Distinct sinonasal microbiota define clinical subtypes of CRSwNP. 💡 Microbiome-based stratification may support personalized therapy for CRSwNP. onlinelibrary.wiley.com/doi/10.1002/...

🗑️ Global landfill systems are major hotspots for antibiotic resistance genes! ⚙️ Metagenomic analyses reveal highly mobile, plasmid-enriched ARGs—dominated by multidrug resistance—and extensive resistome flows within and beyond landfills. onlinelibrary.wiley.com/doi/10.1002/...

🌊A global estuarine virome reveals active virus-carried antibiotic resistance genes. onlinelibrary.wiley.com/doi/10.1002/...

A fast, robust readout framework advances large-fragment DNA data storage. onlinelibrary.wiley.com/doi/10.1002/...

👶 MOMMY study profile: a large prospective birth cohort uncovering early-life microbiome transmission in China. 💡 A unique resource to advance global understanding of early-life microbiome–health trajectories. onlinelibrary.wiley.com/doi/10.1002/...

Tidyplots empowers life scientists with easy code‐based data visualization onlinelibrary.wiley.com/doi/10.1002/...

Gut microbes help black soldier fly larvae cope with excess uric acid. ⚙️ A uric acid–degrading Enterococcus faecalis strain restores larval growth and improves bioconversion efficiency by catabolizing dietary UA. onlinelibrary.wiley.com/doi/10.1002/...

🎯 Engineered bacteria target cancer-associated fibroblasts to break tumor protection! ⚙️ CAT-BLAST, a FAP-targeting E. coli platform, selectively eliminates Cancer-associated fibroblasts and induces tumor cell apoptosis via ClyA secretion. onlinelibrary.wiley.com/doi/10.1002/...

🧪 Nanoplastic exposure disrupts bile acid metabolism and gut microbiota, driving systemic metabolic collapse. onlinelibrary.wiley.com/doi/10.1002/...

Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution 🐄https://onlinelibrary.wiley.com/doi/10.1002/imt2.70100

Efficacy and biomarker analysis of neoadjuvant disitamab vedotin (RC48‐ADC) combined immunotherapy in patients with muscle‐invasive bladder cancer onlinelibrary.wiley.com/doi/10.1002/...

💡 An Interpretable Machine Learning Model for Predicting 5-Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data! onlinelibrary.wiley.com/doi/10.1002/...

How does time‐restricted feeding mitigate Alzheimer's disease‐associated cognitive impairments? The role of the B. pseudolongum‐propionic acid‐FFAR3 axis. onlinelibrary.wiley.com/doi/10.1002/...

Dynamics and Regulation of Maternal–Fetal Interface Macrophages: From Immune Tolerance to Pregnancy Outcomes 🧐How macrophage signaling transforms maternal-fetal health and therapeutic discovery？ onlinelibrary.wiley.com/doi/10.1002/...

Network perturbation analysis identifies new molecular subtypes of endometrial cancer 💫Three distinct subtypes show different clinical outcomes. onlinelibrary.wiley.com/doi/10.1002/...

⚡️Gut microbes and liver metabolism collaborate to fight fatty liver! ⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation. onlinelibrary.wiley.com/doi/10.1002/...

💡 Microbiota-Gut-Brain Axis Multi-Organ Chip Construction and Applications in Drug Evaluation onlinelibrary.wiley.com/doi/10.1002/...

Wuda Granule Improves the Gastrointestinal Motility via Gut-Brain Axis in Beagle Dogs! ⚙️ Central Wuda Granule drives whole-gut motility. #GutBrainAxis #TraditionalMedicine #Neurogastroenterology onlinelibrary.wiley.com/doi/10.1002/...