Specificity landscapes of 40 R2R3‐MYBs reveal how paralogs target different cis‐elements by homodimeric binding onlinelibrary.wiley.com/doi/10.1002/...

Gut microbiota-derived tryptophan metabolites improve total parenteral nutrition-associated infections by regulating Group 3 innate lymphoid cells doi.org/10.1002/imt2...

Linking dietary fiber to human malady through cumulative profiling of microbiota disturbance onlinelibrary.wiley.com/doi/10.1002/...

The prognostic and therapeutic significance of polyunsaturated fatty acid‐derived oxylipins in ST‐segment elevation myocardial infarction onlinelibrary.wiley.com/doi/10.1002/...

Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities onlinelibrary.wiley.com/doi/10.1002/...

ImageGP 2 for enhanced data visualization and reproducible analysis in biomedical research onlinelibrary.wiley.com/doi/10.1002/...

Climate factors drive the local adaptation of Old World cattle onlinelibrary.wiley.com/doi/10.1002/...

Fast bootstrap and reliable readout using hidden references for DNA data storage onlinelibrary.wiley.com/doi/10.1002/...

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts onlinelibrary.wiley.com/doi/10.1002/...

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging Centenarian-enriched Clostridium scindens promotes healthy aging by stabilizing gut microbial networks and producing IAA. onlinelibrary.wiley.com/doi/10.1002/...

microeco 2: A comprehensive R package for downstream analysis of microbiome omics data 📊microeco 2.0 brings machine learning, multi-omics, and advanced microbiome analytics into one streamlined R workflow. onlinelibrary.wiley.com/doi/10.1002/...

MetOrigin 2.0: Advancing the discovery of microbial metabolites and their origins - Yu - 2024 - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Patient-derived organoid-immune co-cultures integrated with multi-omics reveal immunotherapy resistance mechanisms in urothelial carcinoma ❄️➡️🔥 Erdafitinib turns FGFR3-mutant “cold” bladder tumors hot again by rewiring the FGFR3–STAT5–IRF2 immune axis. onlinelibrary.wiley.com/doi/10.1002/...

Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis Cirrhosis drives an “oralization” of the gut microbiome, reshaping microbial metabolism toward ammonia and acetate production. onlinelibrary.wiley.com/doi/10.1002/...

Spinal cord injury induces acute microbiome shock and system-wide transcriptomic reprogramming 🤔The newly developed SCIGAMA maps gut microbiota and systemic molecular responses after spinal cord injury (SCI). onlinelibrary.wiley.com/doi/10.1002/...

FluNexus: A versatile web platform for antigenic prediction and visualization of influenza A viruses - Li - 2026 - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Intratumoral Enterobacter hormaechei drives gemcitabine resistance in pancreatic cancer via cddL-mediated drug inactivation 💊 Antibiotic co-treatment restores drug sensitivity while reducing chemotherapy dosage. #Pancreatic #Microbiome onlinelibrary.wiley.com/doi/10.1002/...

Navigating the future of nano‐pesticides: A perspective on design, efficacy, mechanisms, and environmental stewardship 🌱Nano-pesticides are reshaping crop protection toward sustainable agriculture. onlinelibrary.wiley.com/doi/10.1002/...

🔥Latest research! Microbial synthetic community ARC prevents aflatoxin and increases rhizobia-legume nodulation couplingly #MicrobialSolutions #FoodSecurity doi.org/10.1002/imt2...

⚡Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer. Unmodified PL unleashes a H2O2 storm, killing ovarian cancer cells without needing conversion! doi.org/10.1002/imm3...

You are what you eat! Unlocking gut microbiota-mediated biotransformation of dietary phytochemicals doi.org/10.1002/imo2...

L-EasyARG: A long-read metagenomics tool for rapid antibiotic-resistance-gene profiling #Metagenome #ARG doi.org/10.1002/imo2...

🔥Latest Article! Single-cell analysis uncovers smooth muscle cell subtype switching as a key driver of fibrosis, inflammation, and vascular disruption in aortic dissection. #AorticDissection #SingleCell #Vascular #Fibrosis onlinelibrary.wiley.com/doi/10.1002/...

🧬Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells ⚙️ This attention-based model traces rare CTCs directly from blood without enrichment, supporting early detection and anti-metastatic strategies. onlinelibrary.wiley.com/doi/10.1002/...

The DGKα/PA axis drives immune evasion by activating NF-κB and upregulating PD-L1 in tumors. ⚙️ Inhibiting DGKα reduces PD-L1, enhances CTL infiltration, and improves ICI efficacy, with plasma PA as a potential biomarker in gastrointestinal cancers. onlinelibrary.wiley.com/doi/10.1002/...

💪Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming ⚙️ Enrichment of Lactobacillus johnsonii and secondary bile acids activates PAX7/NMRK2 pathways, promoting muscle regeneration. onlinelibrary.wiley.com/doi/10.1002/...

🧐Microbial metabolites in tumor epigenetic regulation The gut microbiome reshapes tumor epigenetics via metabolite signaling.Bile acids and tryptophan-derived ligands regulate HDAC/DNMT/AhR pathways, altering chromatin states and tumor behavior. onlinelibrary.wiley.com/doi/10.1002/...

Spatial multi-omics identifies a NOTCH3-mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma Fibrosis-driven immune exclusion in HCC is linked to endothelial–CAF crosstalk… onlinelibrary.wiley.com/doi/10.1002/...

👏A large-scale single-cell transcriptomic atlas indicates the immune panorama of influenza A infection We generated a large-scale single-cell transcriptomic atlas from peripheral blood, profiling more than 612,010 cells from 97 individuals. #HostResponse onlinelibrary.wiley.com/doi/10.1002/...

Two stable gut microbiome guilds predict liver tumor class and treatment responses ⚙️ Functionally opposing microbial guilds highlight an ecological basis for tumor progression and clinical outcomes. #Hepatocellular onlinelibrary.wiley.com/doi/10.1002/...

Sangerbox 2: Enhanced functionalities and update for a comprehensive clinical bioinformatics data analysis platform onlinelibrary.wiley.com/doi/10.1002/...

STAGER checklist: Standardized testing and assessment guidelines for evaluating generative artificial intelligence reliability onlinelibrary.wiley.com/doi/10.1002/...

USEARCH 12: Open-source software for sequencing analysis in bioinformatics and microbiome onlinelibrary.wiley.com/doi/10.1002/...

iNAP 2.0: Harnessing metabolic complementarity in microbial network analysis onlinelibrary.wiley.com/doi/10.1002/...

Duck gut metagenome reveals the microbiome signatures linked to intestinal regional, temporal development, and rearing condition onlinelibrary.wiley.com/doi/10.1002/...

Specificity landscapes of 40 R2R3-MYBs reveal how paralogs target different cis-elements by homodimeric binding onlinelibrary.wiley.com/doi/10.1002/...

Two telomere-to-telomere pig genome assemblies and pan-genome analyses provide insights into genomic structural landscape and genetic adaptations onlinelibrary.wiley.com/doi/10.1002/...

The microbiome in cancer onlinelibrary.wiley.com/doi/10.1002/...

HLF and PPARα axis regulates metabolic-associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota onlinelibrary.wiley.com/doi/10.1002/...

Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell differentiation onlinelibrary.wiley.com/doi/10.1002/...

Age-specific reference intervals for plasma amino acids and their associations with nutrient intake in the Chinese pediatric population onlinelibrary.wiley.com/doi/10.1002/...

RepliChrom: Interpretable machine learning predicts cancer-associated enhancer-promoter interactions using DNA replication timing onlinelibrary.wiley.com/doi/10.1002/...

scRiskCell: A single-cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes onlinelibrary.wiley.com/doi/10.1002/...

Climate factors drive the local adaptation of Old World cattle onlinelibrary.wiley.com/doi/10.1002/...

🌱 A clickable probe-based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts onlinelibrary.wiley.com/doi/10.1002/...

🤔A microbiota-targeted peptide shows promise for protecting the intestine from radiation injury. Inhibition of ferroptosis by microbiota-derived lithocholic acid underlies the intestinal radioprotection of a host defensin-derived oligopeptide. onlinelibrary.wiley.com/doi/10.1002/...

Metabolic reprogramming of intestinal epithelial cells offers a new strategy for IBD–CDI treatment 💊 An oral proton-reprogrammed nanomedicine to break the inflammatory bowel disease-Clostridium difficile infection vicious cycle @WileyHealth onlinelibrary.wiley.com/doi/10.1002/...

🌿Curcuminoids amplify host innate antiviral immunity via the CRYAB-RBM26 axis in viral infection #VirusDefense #Curcuminoids #ScientificBreakthrough onlinelibrary.wiley.com/doi/10.1002/...

🚀 New breakthrough in cancer detection! Chromatin unwinding state for in situ identification and lineage tracing of circulating tumor cells #CancerResearch #LiquidBiopsy #PanCTC #CancerDetection #AIinMedicine onlinelibrary.wiley.com/doi/10.1002/...

👏 Targeting ferroptosis in NASH 🧐 A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitise. #NASH #Ferroptosis #LiverDisease #Metabolism onlinelibrary.wiley.com/doi/10.1002/...