👶 MOMMY study profile: a large prospective birth cohort uncovering early-life microbiome transmission in China. 💡 A unique resource to advance global understanding of early-life microbiome–health trajectories. onlinelibrary.wiley.com/doi/10.1002/...

Tidyplots empowers life scientists with easy code‐based data visualization onlinelibrary.wiley.com/doi/10.1002/...

Gut microbes help black soldier fly larvae cope with excess uric acid. ⚙️ A uric acid–degrading Enterococcus faecalis strain restores larval growth and improves bioconversion efficiency by catabolizing dietary UA. onlinelibrary.wiley.com/doi/10.1002/...

🎯 Engineered bacteria target cancer-associated fibroblasts to break tumor protection! ⚙️ CAT-BLAST, a FAP-targeting E. coli platform, selectively eliminates Cancer-associated fibroblasts and induces tumor cell apoptosis via ClyA secretion. onlinelibrary.wiley.com/doi/10.1002/...

🧪 Nanoplastic exposure disrupts bile acid metabolism and gut microbiota, driving systemic metabolic collapse. onlinelibrary.wiley.com/doi/10.1002/...

Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution 🐄https://onlinelibrary.wiley.com/doi/10.1002/imt2.70100

Efficacy and biomarker analysis of neoadjuvant disitamab vedotin (RC48‐ADC) combined immunotherapy in patients with muscle‐invasive bladder cancer onlinelibrary.wiley.com/doi/10.1002/...

💡 An Interpretable Machine Learning Model for Predicting 5-Year Survival in Breast Cancer Based on Integration of Proteomics and Clinical Data! onlinelibrary.wiley.com/doi/10.1002/...

How does time‐restricted feeding mitigate Alzheimer's disease‐associated cognitive impairments? The role of the B. pseudolongum‐propionic acid‐FFAR3 axis. onlinelibrary.wiley.com/doi/10.1002/...

Dynamics and Regulation of Maternal–Fetal Interface Macrophages: From Immune Tolerance to Pregnancy Outcomes 🧐How macrophage signaling transforms maternal-fetal health and therapeutic discovery？ onlinelibrary.wiley.com/doi/10.1002/...

Network perturbation analysis identifies new molecular subtypes of endometrial cancer 💫Three distinct subtypes show different clinical outcomes. onlinelibrary.wiley.com/doi/10.1002/...

⚡️Gut microbes and liver metabolism collaborate to fight fatty liver! ⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation. onlinelibrary.wiley.com/doi/10.1002/...

💡 Microbiota-Gut-Brain Axis Multi-Organ Chip Construction and Applications in Drug Evaluation onlinelibrary.wiley.com/doi/10.1002/...

Wuda Granule Improves the Gastrointestinal Motility via Gut-Brain Axis in Beagle Dogs! ⚙️ Central Wuda Granule drives whole-gut motility. #GutBrainAxis #TraditionalMedicine #Neurogastroenterology onlinelibrary.wiley.com/doi/10.1002/...

Integrated multi-omics reveals how potassium sorbate may trigger acute kidney injury. ⚙️ Network toxicology, machine learning & single-cell analysis identify APP as a central hub driving oxidative stress, inflammation & endothelial–immune crosstalk. onlinelibrary.wiley.com/doi/10.1002/...

⚡️Using MicrobTiSDA to infer interspecies interactions from microbiome time-series data. 🔎A tool for analyzing the dynamic patterns of microbial abundance over time. The complete analysis process from data preprocessing to result visualization. onlinelibrary.wiley.com/doi/10.1002/...

🦌🧬 Single-cell multi-omics reveals how deer antlers achieve centimeter-scale daily bone growth. #SingleCell #BoneRegeneration #MultiOmics #DeerAntler onlinelibrary.wiley.com/doi/10.1002/...

🧬Single-cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease #scRNAseq #MolecularMechanisms #iMeta onlinelibrary.wiley.com/doi/10.1002/...

⏳ PhyloSuite v2 makes molecular dating analysis easier ! Using PhyloSuite v2 for molecular phylogeny and tree‐based analyses #Phylogenetics #MolecularDating #Bioinformatics onlinelibrary.wiley.com/doi/10.1002/...

🚀iMeta has been cited over 14,000 times! ⚡️According to statistics from the Dimensions website, as of December 8, 2025, #iMeta has published 349 papers, which have been cited 14,366 times, with an average of 41.16 citations per paper, and it takes only two days to reach 100 citations.

💡 Toward a Medical Data Element Ecosystem (MDEE) for the digital health era! 🌏 Build a comprehensive medical data ecosystem framework that spans the entire data lifecycle and offers a new perspective for advancing practice in the field. onlinelibrary.wiley.com/doi/10.1002/...

🧠 Copper exposure drives #neurotoxicity through a gut–brain metabolic axis! 🔥 It triggers #gut barrier damage and inflammation, leading to #neural injury. 💊 The #probiotic W. coagulans XY2 counteracts toxicity by targeting a multi-layered network. onlinelibrary.wiley.com/doi/10.1002/...

🫁Immune–transcriptomic profiling uncovers a four-gene model AUC 0.94 for lung cancer with pulmonary tuberculosis! 💡#MTB remodels #tumor #microenvironment via metabolic-immune crosstalk. ⚡First #immune-transcriptomic map of #lung cancer plus tuberculosis. onlinelibrary.wiley.com/doi/10.1002/...

🫁🔥 HDM-activated #bronchial #fibroblasts emerge as key drivers of airway #inflammation in allergic #asthma! ⚙️ Bronchial fibroblasts are not only structural cells but also direct responders to #allergens. onlinelibrary.wiley.com/doi/10.1002/...

🧬 CRISPR screen uncovers C9ORF50 as a key regulator of #cancer immune evasion! ⚙️ Blocking this splicing factor triggers #dsRNA buildup, Type I IFN activation & strong T-cell recruitment. onlinelibrary.wiley.com/doi/10.1002/...

Whole #microbiota transplantation restores gut homeostasis throughout the #gastrointestinal tract - Tang - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Gut–X axis - Lin - 2025 - iMeta - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....

🧬 GSE-Seq — high-throughput single-entity sequencing via droplet microfluidics! ⚙️ Integrates #barcode generation, degradable hydrogel processing & long-read #sequencing — uncovering vast microbial “dark matter.” 🔗https://doi.org/10.1002/imt2.70087

🌸 Profiling 6423 Chinese women, this study uncovers a midlife shift in the #vaginal #microbiota— ⚖️ Decline of #Lactobacillus crispatus, rise of #Gardnerella vaginalis around age 40. 🧠 A new #microbiome balance score predicts reproductive health risks. 🔗 doi.org/10.1002/imt2...

🧬 CycloneSEQ #nanopore sequencing rapidly reconstructs multidrug-resistant bacterial genomes! ⚙️ 96.16% read accuracy, 99.98% assembly accuracy. 💡 Complete genomes with just 15× long reads or 5× hybrid data. 🔗 onlinelibrary.wiley.com/doi/10.1002/... #Bioinformatics #BGI

🐭 #Lactiplantibacillus plantarum Hi188 promotes post-weaning growth in mice. 🧪 The #metabolite 5-HIAA activates hepatic #AhR, boosting IGF-1 production. 🧑‍💻 Metagenomic and host transcriptome data reveal that 5-HIAA is co-produced by the host–microbiota axis. 🔗 doi.org/10.1002/imo2... #microbiome

🐶💩 Humans and dogs share more than companionship — their gut microbes evolve together! 🧬 Dogs’ gut microbiomes show greater functional similarity to humans than macaques do. 🔗 onlinelibrary.wiley.com/doi/10.1002/... #microbiome #metabolism

🌟 #iMeta Conference 2025 🧬 Focus: #Microbiology, #medicine, #TCM, #plant science & research talent development 🤝 Empowering innovation & advancing journals globally 🔗 onlinelibrary.wiley.com/doi/10.1002/... #Bioinformatics #microbiome #metagenomics

💥 Can AI solve the #antibiotic resistance crisis? 🤖 By revolutionizing every step of drug discovery—from target ID to lead optimization. 🧬 Two paths: molecular screening & de novo design. ⚙️ #AI accelerates discovery, boosts ADMET prediction & drives multi-target innovation. 🔗 doi.org/10.1002/imm3...

💡 30 scientific recommendations from the #CHINAGUT Conference! 👩‍🔬 63 experts joined forces to shape the future of: 🦠 #Probiotics 💊 Live biotherapeutic products 💩 #FMT The goal: standardization, regulation & precision in #microbiome-based therapies. 🔗 doi.org/10.1002/imt2...

🍩 What happens when Prmt5 is lost in fat cells? 🧬 Lipid genes go down, #glucose metabolism goes up! 💥 #Triglycerides drop while phospholipid & sphingolipid diversity expands. PRMT5 emerges as a key regulator of membrane transport & #cholesterol synthesis. 🔗 doi.org/10.1002/imo2...

Yongxin introduces numerous methods published in iMeta @imetascience.bsky.social #BGIspatialmicrobiome

🌱 What shapes the chemotypes of Atractylodes lancea? Not genes alone! 🧬 Genetic divergence follows altitude & climate. 🌾 #Soil and #microbiome together tune its metabolite profiles. 🦠 Core #rhizosphere & endophytic microbes hold the key. 🔗 doi.org/10.1002/imo2...

🫀 Can plant sterols fight #atherosclerosis? ✅ Yes! #Stigmasterol reduces inflammatory macrophages & foam cells. 💡 It boosts cholesterol efflux, blocks ox-LDL uptake, and modulates AMPK/NF-κB/NLRP3 signaling. 📉 The result: less vascular #inflammation, healthier arteries. 🔗 doi.org/10.1002/imo2...

🧬 New insights into the diversity of #CRISPR–Cas systems! #Metagenomic analyses uncovered 4,112 Cas12 proteins and 6 novel subtypes. 🤖 #AI-based Cas12fam annotates 18 domains. 🌿 Cas12 subtypes show habitat-specific enrichment. 🔗 doi.org/10.1002/imo2... #microbiome #metagenomics #bioinformatics

🚀 #iMeta is reshaping academic communication! 📲 Multi-platform + bilingual strategy expands global reach. 📈 1.36M full-text downloads, >10K citations, IF 33.2 (2024)! 🌐 New sub-journals & events foster a vibrant research ecosystem. 🔗 doi.org/10.1002/imt2... #Journal

Abnormal membrane potentials & ion channel signatures drive #tumor growth, metastasis & immune evasion 💊 Ion channel drugs, tumor-treating fields & nano-delivery offer new precision therapies 🧠 Electro-immunotherapy reshapes the TME 🔗 doi.org/10.1002/imm3... #CancerResearch #Immunotherapy

🧬 Benchmarking 14 spatial clustering methods across ~600 #SpatialTranscriptomics datasets 🧫 10 technologies, 8 organs — consistent insights ⚙️ Clear guidance for method choice & preprocessing 🔗 doi.org/10.1002/imt2... #Bioinformatics #SpatialOmics #scRNA

🌏 #Soil pH shapes microbial #nitrogen cycling in Japanese forests 🌲 🧪 Acidic soils host stress-tolerant microbes retaining N ⚙️ Neutral soils favor energy-efficient taxa releasing #ammonium & driving #nitrification 🔗 doi.org/10.1002/imo2... #SoilHealth #Microbiome #metabolism

🧩 New insights into the #gut–#brain axis: 🦠L-lysine boosts barrier function & eases anxiety via tryptophan metabolism 😟H. biformis strengthens the barrier but worsens #anxiety 💻Multi-omics reveal lysine degradation as a key mechanism 🔗 doi.org/10.1002/imo2... #microbiome #Bioinformatics

🚀 317 R scripts for biomedical research, no coding barrier ⏱️ Standardized design saves time ✅ Verified, annotated, reproducible 🧬 Covers #scRNA-seq, spatial #transcriptomics, #ML & more 🔗 doi.org/10.1002/imm3... #Bioinformatics

🫀🦠 Gut–heart axis in #CAD: distinct microbial & metabolic shifts across normal, sCAD & ACS; ACS signatures partly reversible. Multi-omics #ML outperforms clinical risk factors in stratifying CAD subtypes. 🔗 onlinelibrary.wiley.com/doi/10.1002/... #microbiome

🦠 #Lactobacillus johnsonii-FM1 fights colorectal #cancer: 🌱 Restoring gut diversity & barrier integrity 🔬 Producing VCA via vanillin dehydrogenase ❌ VCA blocks #CRC cell growth & Wnt/β-catenin signaling 👉 A gut microbe–metabolite axis for anti-CRC therapy. 🔗 onlinelibrary.wiley.com/doi/10.1002/...

🚀 #fastp: ultra-fast, full-featured & user-friendly #FASTQ preprocessing tool! ☁️ Cloud-friendly, minimal resources, web-based reports 📊 v1.0 brings enhanced HTML reporting & parallel batch processing onlinelibrary.wiley.com/doi/10.1002/... #Bioinformatics #NGS #sequencing

🌍 New study on hypervirulent #Klebsiella pneumoniae (CC23-K1): 🔹 Geographic distance drives global spread patterns 🔹 >130 gain/loss events show unstable carbapenem resistance 🔹 KPC/NDM (Asia) conflict with #virulence, OXA-48 (Europe) better preserves it 🔗 onlinelibrary.wiley.com/doi/10.1002/...