Happy #MicroscopyMonday everyone! 🔬🤩 Today we are treating you with this beautiful GIF from Adam! 🐭 The image shows a 3D reconstruction of a TdTomato sparse labelling of MOC neurons (at the top of the image) and their iLOC counterparts (shown at the bottom).🧠🧪 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬 We hope you are having a good day! To start off the week in a great way we have today's photo from Char!🌞🧪 The photo shows the apical coil of a 4 day old mouse cochlea stained with the pan-neuronal marker β-tubulin(shown in ❤️)🐁 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬 I hope you will enjoy today's image from Char!🌞 The image shows a Mid-modiolar cryosection of a 25 day old cochlea showing Calb2 staining (💚) in Type I neurons in the Spiral Ganglion and Hair Cells in the Organ of Corti.🐁🧪 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone! 🔬🧪 I hope you are all having a great monday! 🌟 Today's image is from Sarah and it shows a P8 cochlear apex,🐁 with F-actin labelled ❤️ red by phalloidin and inner hair cells glowing 💚 green through AAV-induced GFP expression. #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬✨ Today's photo is from Char and it shows a beautiful immunolabeled image of a 9 day old mouse cochlea.🐁👂 In 💙 you can see the hair cells of the apical section stained beautifully by myosin VIIa!😍 #HearingResearch #Neuroskyence

Happy #MicroscopyMonday everyone!🔬 Have you wondered what goes on in a brain?🧠 Today's image comes from Andrea and it shows calcium activity in neuronal nuclei in a zebrafish!🐟 The blinking shows activation in neurons with warmer colours indicating higher activity✨🧪 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone! 🔬🧪 I hope your week is off to a great start! 🌟 Today's image is from Sarah and it shows a P8 cochlear apex,🐁 with F-actin labelled ❤️ red by phalloidin and inner hair cells glowing 💚 green through AAV-induced GFP expression. #Neuroskyence #HearingResearch

Howdy all! Today's paper spotlight is hot from the presses (hence the watermark) and comes from Pankaj Bhatia. This terrifying work shows how PFAS (forever chemicals) can cause hearing loss through death of cochlear hair cells and their associated neuron! ☠️ www.nature.com/articles/s41...

Huge congrats to Profs. Paul Riley @idrm.ox.ac.uk & Walter Marcotti @hearingshef.bsky.social @sheffielduni.bsky.social for their elections to the Fellowship of the Royal Society! #RockOn #zebrafish

Happy #MicroscopyMonday everyone!🔬🧪 I hope your week has started off great and today's photo will only make it better!🌞 Today Char shows us this beautiful staining of the cochlea neurons (marked ❤️ by beta-tubulin) and the Type 2 SGNs (marked 💚 by peripherin) #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬✨Hope you had a good weekend! Today's photo is from Alice and it shows an immunostaining of outer hair cells in a 2 month old mouse!🧪🐁 Phalloidin (in 💜) stains the body of the hair cells and in green is a lab secret🤫 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬🧪 Today's stunning image comes from Lillian! The image shows the apical part of a 9-day old mouse cochlea with myosin7a ❤️ staining the hair cells, DAPI 💙 staining the nucleus and a ✨mysterious✨ green protein💚👀 #NeuroSkyence #HearingResearch

Today our PhD students Ivy and Zoë showcased their research at the @sheffielduni.bsky.social 2nd Year symposium sharing their posters and getting some invaluable feedback and, we are sure, lots of praises for their excellent work!🧪❤️ #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬✨ Today we are back with a good one!🤩 Today's photo comes from Char and shows the apical turn of a 4 day-old mouse cochlea immunostained against the ribbon synapse marker CtBP2 (❤️) and Myosin 7a (💙) as a hair cell marker. 🐁🧪 #Neuroskyence #HearingResearch

The hearing group took part in The Physiological Society's "Lab lunch" event to celebrate 150 years of the society. We had a decent chat about physiology over a sandwich, and got to play with stickers and fun hats! @physoc.bsky.social

Happy #MicroscopyMonday everyone!🔬✨ To fight off the weekend blues Char is sharing a great photo showing a mid-modiolar section of the spiral ganglion in an adult mouse.🧪🐁 Red (parvalbumin) and green (Calb2) stain two different types of spiral ganglion neurons!❤️💚 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬✨ Today's stunning new image comes from Char and it shows a mid-modiolar section of the spiral ganglion in an adult mouse.🧪🐁 In the image red (beta-tubulin) stains the spiral ganglion neurons and blue (DAPI) stains the cell nuclei! ❤️💙 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday !🔬✨ Today Elli treats us to a great recording of inner hair cells in the cochlea of a 7-day-old mouse, showing spontaneous activity during development.👂🐁 The colours show calcium activity, with brighter colours indicating higher activity.💜❤️💛🧪 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone! 🔬🤩 Today’s image comes from Lillian and it’s her first immuno!🐁🧪 In the image, red ❤️ highlights myo7a, which shows the hair cell bodies! Beautiful! #Neuroskyence #HearingResearch

We are excited to announce a new Post-doc position! 🚨 This project will be based at Swansea University, under the supervision of Dr Emma Kenyon, and will explore the structure and function of the cupulae of the lateral line neuromasts in zebrafish. More details: www.swansea.ac.uk/jobs-at-swan...

Today's (long overdue) paper spotlight actually comes from us! This review is a great place to start if you want to understand spontaneous activity in the cochlea! Definitely worth a read, even if it's just to look at the cute cartoons :) The paper: pubmed.ncbi.nlm.nih.gov/41731255/

Today is #WorldHearingDay! 👂 This year's topic focuses on hearing loss in school-age children, and highlights the difficulties in diagnosing hearing loss at such an early age especially in regions with low resources.👨‍👩‍👧‍👧 www.who.int/campaigns/wo... #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬 Today's image comes from Ivy and it shows a beautiful dissection of the organ of Corti of a mouse!😮🐁 In the image the 💚 signals are myosin VI, an essential protein expressed in auditory hair cells for hearing acquisition!👂✨🧪 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🔬🤩 Today's image is a stunning one and comes from Zoë! In this image we can see both the inner and outer hair cells stained with Phalloidin (in ❤️) whereas the supporting cells are outlined with Cx30 and Cx26 (respectively in 💚 and 💜)🐁 #Neuroskyence #HearingResearch

Last week in beautiful Puerto Rico🌞, our amazing PIs Ginny and Adam presented their work at the ARO conference👂, soaking up inspiring talks and posters, trading the UK freeze🥶 for sunshine😎 while sharing science and learning from others. 🧪 #ARO #HearingResearch #Neuroskyence

This week's #MicroscopyMonday is the second part of a previous one!🔬👀 Two weeks ago we showed you a view of the synapses of a 3 day old mouse and today we are showing you how it changes over time with this beautiful image of a 12 day old mouse coming from Char! 🧪🐁 #Neuroskyence #HearingResearch

Happy #MicroscopyMonday everyone!🧪🔬Today's image comes from Sarah and it shows the hair cells (highlighted by Myo7a in red) and the spiral ganglion neurons (highlighted by Beta tubulin in blue) in a two month old mouse cochlea!🐁👂 #NeuroSkyence #HearingResearch

Happy #MicroscopyMonday everyone! 🔬To celebrate February we have a beautiful image from Char and shows a stunning view of the synapses of the inner hair cells in a 3-day-old mouse.🐁👂In this snapshot CtBP2, in red, labels the presynaptic ribbons and PSD95, in green, labels the postsynaptic sites.✨🧪

Happy #MicroscopyMonday everyone!🔬🤩Today's image is something a little bit different, it comes from Andrea and shows a phalloidin staining of the inner ear of a 30 hours old zebrafish with the first hair cells already present (highlighted by the arrows) and growing!🐟🧪 #NeuroSkyence #HearingResearch

New Year, but same old happy #MicroscopyMonday everyone! 🎆We kick off 2026 with a beautiful image from Char showing the apex dissected from a 34 day old mouse cochlea.🐁 Beta III tubulin (in green) shows the spiral ganglion neurons in the center and their afferent fibres!🧪🔬 #NeuroSkyence

📢Howdy all, just two weeks until the deadline of this PhD opportunity within the hearing group! Please share around as much as possible. This exciting project within the Carlton lab would be a great fit for someone interested in sensory neuroscience!👂🧠 www.findaphd.com/phds/project...

Christmas is near and we would like to wish all of you happy holidays from everyone at the Hearing Research Group!🎄🎆👂

We wanted to say a big congratulations to our very own Scot, Dr. Charlie Cranston! Big congratulations for passing your viva this week! We can't wait to see what the future holds for you and we know it will be bright! Good job Dr. Cranston!🎉🎊👏🎆

Happy #MicroscopyMonday everyone! 🔬Today's image is from Char and shows a super-resolution Airyscan view of the synapses of the inner hair cells in a 34-day-old mouse.🐁👂In this snapshot CtBP2, in red, labels the presynaptic ribbons and PSD95, in green, labels the postsynaptic sites.✨🧪 #NeuroSkyence

Happy #MicroscopyMonday everyone!🔬 Today's image comes from Alice and it's a great fluorescent image of inner hair cells (stained with Phalloidin, magenta) from a 2-months old mutant.🐁 In this photo the expression of Baiap2l2 (green) was successfully restored with AAV-gene therapy.💉🧪 #NeuroSkyence

💚 🏆 We’re very happy to have received the Sustainability Lab Leaf Silver Award for creating an even greener, more sustainable research environment! 🧪 🥬 Many many thanks to everyone in the lab for their efforts #Sustainability #GreenLabs #SheffieldHearingGroup

Rinta Mathew: Postdoc Research: Investigating regulation of signal processing in developing and ageing mouse cochlea in vivo and how these influence central auditory neuronal pathways. Method: 2-photon imaging & AAV-gene delivery Twitter: x.com/MathewRinta Lab snack: Nature Valley Peanut & Chocolate

Happy #MicroscopyMonday everyone! 🌟🔬 Here’s an image from Ivy of outer hair cells (OHCs) and inner hair cells (IHCs) from a P20 mouse.. 🐁✨#Microscopy #HearingResearch #Cochlea #Neuroscience #Neuroskyence

🌿🏅 We’re proud to announce the Sheffield Hearing Group has been awarded the Sustainability Lab Leaf Bronze Award for creating a greener, more sustainable research environment! 🌎🔬Huge thanks to everyone in the lab for their efforts🌱👏 #Sustainability #GreenLabs #SheffieldHearingGroup

Howdy all, today's spotlight comes from Saman Hussain and was published in September. This (very pretty) paper identifies spontaneous calcium activity within the sound-detecting stereocilia driven by the MET channel, and independent from the usual calcium waves! pmc.ncbi.nlm.nih.gov/articles/PMC...

Happy #MicroscopyMonday everyone!🔬🌟Nic has taken a cross-section image of the retina under the microscope: red shows the Retinal Pigment Epithelial cells, orange shows photoreceptor cell bodies with cilia & green shows the outer nuclear layer with just photoreceptor cell bodies 👁️✨ #neuroskyence

📢Howdy all, I'm excited to announce a new PhD opening within the Carlton lab in the hearing research group! This project will use primarily electrophysiology to investigate how noise influences feedback to the cochlea from the brainstem! More details can be found at: www.findaphd.com/phds/project...

Lillian Smith | PhD student Research focus: Understanding the mechanisms associated with mitochondria dysfunction underpinning ARHL and neurodegenerative diseases using in vivo physiology, 2-photon functional imaging, RNA sequencing, and immunolabeling Fun fact: My go-to lab snack is mini cheddars

Happy #MicroscopyMonday everyone!🌟🔬 Today's photo comes from Alice showing an scanning electron microscopy image of outer hair cells lacking many stereocilia due to abnormal expression of a protein important for hair bundle maintenance! 🧪🐁

Last week we said goodbye and good luck to Francesca, who’s been an amazing part of the Sheffield Hearing Group! Thank you, Fran, for everything — the lab won’t be the same without you! 🧪🌟

Howdy all. Recently one of our PIs (Adam) appeared on The Naked Scientists podcast to discuss hearing loss and tinnitus! The free full recording can be found on their website at: www.thenakedscientists.com/podcasts/nak... Worth a listen if you're interested in hearing!

Happy #MicroscopyMonday everyone!🌟🔬 Today's photo comes from Zoë and shows the inner and outer hair cells in the organ of Corti of a mouse stained with Phalloidin (in red), the supporting cells outlined with connexin 30 (in green), and the cell nuclei stained with DAPI (in blue).🧪🐁

A quick video on how we Immunolabel proteins in the organ of corti 😊🧪

Happy #MicroscopyMonday 🌟🔬 Todays photo comes from Ginny and shows pre and post synapses from inner hair cells. White stains the nucleus, red stains CtBP2, green stains Shank1 and blue stains GluR2🧪🐁

We've had a busy few weeks as we have returned from an amazing Inner Ear Biology conference in Tübingen!👂 It was inspiring to hear cutting-edge research and disseminate our own—Adam, Alice, and Char gave talks, while Ginny, Federico, Yan, and Andrea presented their latest work in poster sessions!🧑‍🔬🧪